Severe Respiratory Syncytial Virus Disease in Alaska Native Children
Hospitalization rates for respiratory syncytial virus (RSV) infection range from 1 to 20/1000 infants. To determine the rate and severity of RSV infections requiring hospitalization for infants in the Yukon-Kuskokwim (YK) Delta of Alaska, a 3-year prospective surveillance study was conducted. The an...
Published in: | The Journal of Infectious Diseases |
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Main Authors: | , , , , , , , , , , , , |
Format: | Text |
Language: | English |
Published: |
Oxford University Press
1999
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Subjects: | |
Online Access: | http://jid.oxfordjournals.org/cgi/content/short/180/1/41 https://doi.org/10.1086/314841 |
Summary: | Hospitalization rates for respiratory syncytial virus (RSV) infection range from 1 to 20/1000 infants. To determine the rate and severity of RSV infections requiring hospitalization for infants in the Yukon-Kuskokwim (YK) Delta of Alaska, a 3-year prospective surveillance study was conducted. The annual rate of RSV hospitalization for YK Delta infants <1 year of age was 53–249/1000. RSV infection was the most frequent cause of infant hospitalization. RSV disease severity did not differ among non—high-risk infants in the YK Delta and at Johns Hopkins Hospital (JHH). On average, 1/125 infants born in the YK Delta required mechanical ventilation for RSV infection. During the peak season, ∼$1034/child <3 years of age was spent on RSV hospitalization in the YK Delta. In YK Delta infants ⩽6 months old, RSV micro-neutralizing antibody titers <1200 were associated with severe disease (odds, ratio = 6.2 P = .03). In the YK Delta and at JHH, newborns may be at greater risk for severe RSV illness than previously thought. |
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