Immunogenicity of Two Efficacious Outer Membrane Protein-Based Serogroup B Meningococcal Vaccines among Young Adults in Iceland
Serum bactericidal activity (SBA) and ELISA antibody levels elicited by two efficacious serogroup B meningococcal vaccines were measured in a controlled trial involving 408 15- to 20-year-olds. Subjects were given two doses at a 6-week interval of a serogroup B or control vaccine. Response was defin...
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fthighwire:oai:open-archive.highwire.org:jinfdis:177/3/683 2023-05-15T16:49:54+02:00 Immunogenicity of Two Efficacious Outer Membrane Protein-Based Serogroup B Meningococcal Vaccines among Young Adults in Iceland Perkins, B. A. Jonsdottir, K. Briem, H. Griffiths, E. Plikaytis, B. D. Hoiby, E. A. Rosenqvist, E. Holst, J. Nokleby, H. Sotolongo, F. Sierra, G. Campa, H. C. Carlone, G. M. Williams, D. Dykes, J. Kapczynski, D. Tikhomirov, E. Wenger, J. D. Broome, C. V. 1998-03-01 00:00:00.0 text/html http://jid.oxfordjournals.org/cgi/content/short/177/3/683 https://doi.org/10.1086/514232 en eng Oxford University Press http://jid.oxfordjournals.org/cgi/content/short/177/3/683 http://dx.doi.org/10.1086/514232 Copyright (C) 1998, Infectious Diseases Society of America Major Articles TEXT 1998 fthighwire https://doi.org/10.1086/514232 2011-03-13T13:08:16Z Serum bactericidal activity (SBA) and ELISA antibody levels elicited by two efficacious serogroup B meningococcal vaccines were measured in a controlled trial involving 408 15- to 20-year-olds. Subjects were given two doses at a 6-week interval of a serogroup B or control vaccine. Response was defined as ⩾4-fold rise in antibody level. After two doses of the Finlay Institute (Havana) vaccine at 12 months, the proportions of SBA and ELISA responders were not different from those of the control group (15% and 17% [vaccine] vs. 13% and 9% [control], P > .05). After two doses of the National Institute of Public Health (Oslo) vaccine, there were more SBA and ELISA responders than in the control group (47% and 34% [vaccine] vs. 10% and 1% [control]) or the Finlay Institute vaccine group ( P < .05 for both). SBA and ELISA may be insensitive correlates for protective efficacy for some outer membrane protein-based serogroup B meningococcal vaccines. Text Iceland HighWire Press (Stanford University) The Journal of Infectious Diseases 177 3 683 691 |
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Major Articles Perkins, B. A. Jonsdottir, K. Briem, H. Griffiths, E. Plikaytis, B. D. Hoiby, E. A. Rosenqvist, E. Holst, J. Nokleby, H. Sotolongo, F. Sierra, G. Campa, H. C. Carlone, G. M. Williams, D. Dykes, J. Kapczynski, D. Tikhomirov, E. Wenger, J. D. Broome, C. V. Immunogenicity of Two Efficacious Outer Membrane Protein-Based Serogroup B Meningococcal Vaccines among Young Adults in Iceland |
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Major Articles |
description |
Serum bactericidal activity (SBA) and ELISA antibody levels elicited by two efficacious serogroup B meningococcal vaccines were measured in a controlled trial involving 408 15- to 20-year-olds. Subjects were given two doses at a 6-week interval of a serogroup B or control vaccine. Response was defined as ⩾4-fold rise in antibody level. After two doses of the Finlay Institute (Havana) vaccine at 12 months, the proportions of SBA and ELISA responders were not different from those of the control group (15% and 17% [vaccine] vs. 13% and 9% [control], P > .05). After two doses of the National Institute of Public Health (Oslo) vaccine, there were more SBA and ELISA responders than in the control group (47% and 34% [vaccine] vs. 10% and 1% [control]) or the Finlay Institute vaccine group ( P < .05 for both). SBA and ELISA may be insensitive correlates for protective efficacy for some outer membrane protein-based serogroup B meningococcal vaccines. |
format |
Text |
author |
Perkins, B. A. Jonsdottir, K. Briem, H. Griffiths, E. Plikaytis, B. D. Hoiby, E. A. Rosenqvist, E. Holst, J. Nokleby, H. Sotolongo, F. Sierra, G. Campa, H. C. Carlone, G. M. Williams, D. Dykes, J. Kapczynski, D. Tikhomirov, E. Wenger, J. D. Broome, C. V. |
author_facet |
Perkins, B. A. Jonsdottir, K. Briem, H. Griffiths, E. Plikaytis, B. D. Hoiby, E. A. Rosenqvist, E. Holst, J. Nokleby, H. Sotolongo, F. Sierra, G. Campa, H. C. Carlone, G. M. Williams, D. Dykes, J. Kapczynski, D. Tikhomirov, E. Wenger, J. D. Broome, C. V. |
author_sort |
Perkins, B. A. |
title |
Immunogenicity of Two Efficacious Outer Membrane Protein-Based Serogroup B Meningococcal Vaccines among Young Adults in Iceland |
title_short |
Immunogenicity of Two Efficacious Outer Membrane Protein-Based Serogroup B Meningococcal Vaccines among Young Adults in Iceland |
title_full |
Immunogenicity of Two Efficacious Outer Membrane Protein-Based Serogroup B Meningococcal Vaccines among Young Adults in Iceland |
title_fullStr |
Immunogenicity of Two Efficacious Outer Membrane Protein-Based Serogroup B Meningococcal Vaccines among Young Adults in Iceland |
title_full_unstemmed |
Immunogenicity of Two Efficacious Outer Membrane Protein-Based Serogroup B Meningococcal Vaccines among Young Adults in Iceland |
title_sort |
immunogenicity of two efficacious outer membrane protein-based serogroup b meningococcal vaccines among young adults in iceland |
publisher |
Oxford University Press |
publishDate |
1998 |
url |
http://jid.oxfordjournals.org/cgi/content/short/177/3/683 https://doi.org/10.1086/514232 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://jid.oxfordjournals.org/cgi/content/short/177/3/683 http://dx.doi.org/10.1086/514232 |
op_rights |
Copyright (C) 1998, Infectious Diseases Society of America |
op_doi |
https://doi.org/10.1086/514232 |
container_title |
The Journal of Infectious Diseases |
container_volume |
177 |
container_issue |
3 |
container_start_page |
683 |
op_container_end_page |
691 |
_version_ |
1766040077218086912 |