Mutational Bias in Penguin Microsatellite DNA
Analysis of nucleotide sequence variation at a microsatellite DNA locus revealed extensive size homoplasy of alleles in Adélie penguins ( Pygoscelis adeliae ). Variation in the flanking regions at this locus allowed discrimination between mechanisms proposed for length changes in microsatellite DNA...
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Oxford University Press
2005
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fthighwire:oai:open-archive.highwire.org:jhered:esi070v1 2023-05-15T18:03:49+02:00 Mutational Bias in Penguin Microsatellite DNA Shepherd, L. D. Lambert, D. M. 2005-07-01 07:32:14.0 text/html http://jhered.oxfordjournals.org/cgi/content/short/esi070v1 https://doi.org/10.1093/jhered/esi070 en eng Oxford University Press http://jhered.oxfordjournals.org/cgi/content/short/esi070v1 http://dx.doi.org/10.1093/jhered/esi070 Copyright (C) 2005, American Genetic Association Brief Communication TEXT 2005 fthighwire https://doi.org/10.1093/jhered/esi070 2013-05-28T10:25:13Z Analysis of nucleotide sequence variation at a microsatellite DNA locus revealed extensive size homoplasy of alleles in Adélie penguins ( Pygoscelis adeliae ). Variation in the flanking regions at this locus allowed discrimination between mechanisms proposed for length changes in microsatellite DNA alleles. We further examined the structure of alleles for the same microsatellite DNA locus across 11 additional species of penguin (Spheniscidae) by mapping allele sequences onto an independent penguin phylogeny. Our analysis indicated that the repeat motifs appear to have evolved independently on several occasions. We observed sequence instability in the region bordering the repeat tract with a transversional bias predominating. We propose that this bias results from inaccurate DNA replication owing to the sequence context of this repeat tract. Because we show that regions flanking repeat sequences exhibit this mutational bias, this cautions against the use of such regions for phylogeny reconstruction. Text Pygoscelis adeliae HighWire Press (Stanford University) Journal of Heredity 96 5 566 571 |
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Open Polar |
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HighWire Press (Stanford University) |
op_collection_id |
fthighwire |
language |
English |
topic |
Brief Communication |
spellingShingle |
Brief Communication Shepherd, L. D. Lambert, D. M. Mutational Bias in Penguin Microsatellite DNA |
topic_facet |
Brief Communication |
description |
Analysis of nucleotide sequence variation at a microsatellite DNA locus revealed extensive size homoplasy of alleles in Adélie penguins ( Pygoscelis adeliae ). Variation in the flanking regions at this locus allowed discrimination between mechanisms proposed for length changes in microsatellite DNA alleles. We further examined the structure of alleles for the same microsatellite DNA locus across 11 additional species of penguin (Spheniscidae) by mapping allele sequences onto an independent penguin phylogeny. Our analysis indicated that the repeat motifs appear to have evolved independently on several occasions. We observed sequence instability in the region bordering the repeat tract with a transversional bias predominating. We propose that this bias results from inaccurate DNA replication owing to the sequence context of this repeat tract. Because we show that regions flanking repeat sequences exhibit this mutational bias, this cautions against the use of such regions for phylogeny reconstruction. |
format |
Text |
author |
Shepherd, L. D. Lambert, D. M. |
author_facet |
Shepherd, L. D. Lambert, D. M. |
author_sort |
Shepherd, L. D. |
title |
Mutational Bias in Penguin Microsatellite DNA |
title_short |
Mutational Bias in Penguin Microsatellite DNA |
title_full |
Mutational Bias in Penguin Microsatellite DNA |
title_fullStr |
Mutational Bias in Penguin Microsatellite DNA |
title_full_unstemmed |
Mutational Bias in Penguin Microsatellite DNA |
title_sort |
mutational bias in penguin microsatellite dna |
publisher |
Oxford University Press |
publishDate |
2005 |
url |
http://jhered.oxfordjournals.org/cgi/content/short/esi070v1 https://doi.org/10.1093/jhered/esi070 |
genre |
Pygoscelis adeliae |
genre_facet |
Pygoscelis adeliae |
op_relation |
http://jhered.oxfordjournals.org/cgi/content/short/esi070v1 http://dx.doi.org/10.1093/jhered/esi070 |
op_rights |
Copyright (C) 2005, American Genetic Association |
op_doi |
https://doi.org/10.1093/jhered/esi070 |
container_title |
Journal of Heredity |
container_volume |
96 |
container_issue |
5 |
container_start_page |
566 |
op_container_end_page |
571 |
_version_ |
1766174838947315712 |