Aluminum exposure impacts brain plasticity and behavior in Atlantic salmon (Salmo salar)

• Published in: Journal of Experimental Biology
• Main Authors: Grassie, Cairsty, Braithwaite, Victoria A., Nilsson, Jonatan, Nilsen, Tom O., Teien, Hans-Christian, Handeland, Sigurd O., Stefansson, Sigurd O., Tronci, Valentina, Gorissen, Marnix, Flik, Gert, Ebbesson, Lars O. E.
• Format: Text
• Language: English
• Published: Company of Biologists 2013
• Subjects: Research Article; Atlantic salmon; Salmo salar
• Online Access: http://jeb.biologists.org/cgi/content/short/jeb.083550v1; https://doi.org/10.1242/jeb.083550

Aluminum (Al) toxicity occurs frequently in natural aquatic ecosystems as a result of acid deposition and natural weathering processes. Detrimental effects of Al toxicity on aquatic organisms are well known and can have consequences for survival. Fish exposed to Al in low pH waters will experience physiological and neuroendocrine changes that disrupt homeostasis and alter behavior. To investigate the effects of Al exposure to both brain and behavior, Atlantic salmon ( Salmo salar ) kept in water treated with Al (pH 5.7, 0.37±0.04 µmol 1-1 of Al) for 2 weeks were compared to fish kept in a control condition (pH 6.7, <0.04 µmol 1-1 of Al). Fish exposed to Al and acidic conditions had increased Al accumulation in the gills and decreased gill Na+, K+-ATPase activity, which impaired osmoreguatory capacity and caused physiological stress, indicated by elevated plasma cortisol and glucose levels. Here we show for the first time that exposure to Al in acidic conditions also impaired learning performance in a maze task. Al toxicity reduced the expression of NeuroD1 transcript levels in the forebrain of exposed fish. As in mammals, these data show that exposure to chronic stress, such as acidified Al, can reduce neural plasticity during behavioral challenges in salmon, and may impair coping ability to new environments.