Angiotensin II-induced inotropism requires an endocardial endothelium-nitric oxide mechanism in the in-vitro heart of Anguilla anguilla

• Published in: Journal of Experimental Biology
• Main Authors: Imbrogno, Sandra, Cerra, Maria Carmela, Tota, Bruno
• Format: Text
• Language: English
• Published: Company of Biologists 2003
• Subjects: Research Article; Triton; Anguilla anguilla
• Online Access: http://jeb.biologists.org/cgi/content/short/206/15/2675; https://doi.org/10.1242/jeb.00468

Using an isolated working heart preparation we show that angiotensin II (ANG II), at concentrations of 10-10–10-7 mol l-1, elicits negative chronotropism and inotropism in the freshwater eel Anguilla anguilla . The negative inotropism was insensitive to losartan and CGP42112 (AT 1 and AT 2 ANG II re...