Effects of Substance P and Vasoactive Intestinal Polypeptide on Gastrointestinal Blood Flow in the Atlantic Cod Gadus Morhua
The cardiovascular effects of vasoactive intestinal polypeptide (VIP) and substance P (SP) in vivo were studied in the Atlantic cod Gadus morhua . Special interest was focused on the distribution of blood to the gastrointestinal circulation. VIP increased the blood flow to the gut by increasing card...
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1991
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fthighwire:oai:open-archive.highwire.org:jexbio:156/1/361 2023-05-15T15:27:11+02:00 Effects of Substance P and Vasoactive Intestinal Polypeptide on Gastrointestinal Blood Flow in the Atlantic Cod Gadus Morhua JENSEN, JÖRGEN AXELSSON, MICHAEL HOLMGREN, SUSANNE 1991-03-01 00:00:00.0 text/html http://jeb.biologists.org/cgi/content/short/156/1/361 en eng Company of Biologists http://jeb.biologists.org/cgi/content/short/156/1/361 Copyright (C) 1991, Company of Biologists Journal Articles TEXT 1991 fthighwire 2013-04-02T07:28:33Z The cardiovascular effects of vasoactive intestinal polypeptide (VIP) and substance P (SP) in vivo were studied in the Atlantic cod Gadus morhua . Special interest was focused on the distribution of blood to the gastrointestinal circulation. VIP increased the blood flow to the gut by increasing cardiac output and by decreasing resistance in the vascular bed supplied by the coeliac artery. In addition, VIP had an inhibitory effect on spontaneous stomach motility. SP induced a triphasic response in the coeliac artery blood flow. An initial increase was followed by a rapid decrease, to the control level or below, and a second increase in flow. The triphasic response was not changed after vagotomy, while atropine blocked the second phase, the decrease, indicating that a local cholinergic mechanism is involved. The significance of this temporary decrease in flow remains to be elucidated. SP also caused an increase in cardiac output and in mesenteric artery blood flow. In addition to the increase in cardiac output, the increase in gastrointestinal blood flow produced by SP is accomplished by a decreased resistance in the coeliac and mesenteric vascular beds. Text atlantic cod Gadus morhua HighWire Press (Stanford University) |
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Journal Articles |
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Journal Articles JENSEN, JÖRGEN AXELSSON, MICHAEL HOLMGREN, SUSANNE Effects of Substance P and Vasoactive Intestinal Polypeptide on Gastrointestinal Blood Flow in the Atlantic Cod Gadus Morhua |
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Journal Articles |
description |
The cardiovascular effects of vasoactive intestinal polypeptide (VIP) and substance P (SP) in vivo were studied in the Atlantic cod Gadus morhua . Special interest was focused on the distribution of blood to the gastrointestinal circulation. VIP increased the blood flow to the gut by increasing cardiac output and by decreasing resistance in the vascular bed supplied by the coeliac artery. In addition, VIP had an inhibitory effect on spontaneous stomach motility. SP induced a triphasic response in the coeliac artery blood flow. An initial increase was followed by a rapid decrease, to the control level or below, and a second increase in flow. The triphasic response was not changed after vagotomy, while atropine blocked the second phase, the decrease, indicating that a local cholinergic mechanism is involved. The significance of this temporary decrease in flow remains to be elucidated. SP also caused an increase in cardiac output and in mesenteric artery blood flow. In addition to the increase in cardiac output, the increase in gastrointestinal blood flow produced by SP is accomplished by a decreased resistance in the coeliac and mesenteric vascular beds. |
format |
Text |
author |
JENSEN, JÖRGEN AXELSSON, MICHAEL HOLMGREN, SUSANNE |
author_facet |
JENSEN, JÖRGEN AXELSSON, MICHAEL HOLMGREN, SUSANNE |
author_sort |
JENSEN, JÖRGEN |
title |
Effects of Substance P and Vasoactive Intestinal Polypeptide on Gastrointestinal Blood Flow in the Atlantic Cod Gadus Morhua |
title_short |
Effects of Substance P and Vasoactive Intestinal Polypeptide on Gastrointestinal Blood Flow in the Atlantic Cod Gadus Morhua |
title_full |
Effects of Substance P and Vasoactive Intestinal Polypeptide on Gastrointestinal Blood Flow in the Atlantic Cod Gadus Morhua |
title_fullStr |
Effects of Substance P and Vasoactive Intestinal Polypeptide on Gastrointestinal Blood Flow in the Atlantic Cod Gadus Morhua |
title_full_unstemmed |
Effects of Substance P and Vasoactive Intestinal Polypeptide on Gastrointestinal Blood Flow in the Atlantic Cod Gadus Morhua |
title_sort |
effects of substance p and vasoactive intestinal polypeptide on gastrointestinal blood flow in the atlantic cod gadus morhua |
publisher |
Company of Biologists |
publishDate |
1991 |
url |
http://jeb.biologists.org/cgi/content/short/156/1/361 |
genre |
atlantic cod Gadus morhua |
genre_facet |
atlantic cod Gadus morhua |
op_relation |
http://jeb.biologists.org/cgi/content/short/156/1/361 |
op_rights |
Copyright (C) 1991, Company of Biologists |
_version_ |
1766357640358658048 |