Why does Russia have such high cardiovascular mortality rates? Comparisons of blood-based biomarkers with Norway implicate non-ischaemic cardiac damage
Background Russia has one of the highest rates of mortality from cardiovascular disease (CVD). At age 35–69 years, they are eight times higher than in neighbouring Norway. Comparing profiles of blood-based CVD biomarkers between these two populations can help identify reasons for this substantial di...
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fthighwire:oai:open-archive.highwire.org:jech:74/9/698 2023-05-15T18:34:18+02:00 Why does Russia have such high cardiovascular mortality rates? Comparisons of blood-based biomarkers with Norway implicate non-ischaemic cardiac damage Lakunchykova, Olena Averina, Maria Wilsgaard, Tom Watkins, Hugh Malyutina, Sofia Ragino, Yulia Keogh, Ruth H Kudryavtsev, Alexander V Govorun, Vadim Cook, Sarah Schirmer, Henrik Eggen, Anne Elise Hopstock, Laila Arnesdatter Leon, David A 2020-09-01 00:00:00.0 text/html http://jech.bmj.com/cgi/content/short/74/9/698 https://doi.org/10.1136/jech-2020-213885 en eng BMJ Publishing Group Ltd http://jech.bmj.com/cgi/content/short/74/9/698 http://dx.doi.org/10.1136/jech-2020-213885 Copyright (C) 2020, BMJ Publishing Group Ltd Original research TEXT 2020 fthighwire https://doi.org/10.1136/jech-2020-213885 2020-08-21T10:44:32Z Background Russia has one of the highest rates of mortality from cardiovascular disease (CVD). At age 35–69 years, they are eight times higher than in neighbouring Norway. Comparing profiles of blood-based CVD biomarkers between these two populations can help identify reasons for this substantial difference in risk. Methods We compared age-standardised mean levels of CVD biomarkers for men and women aged 40–69 years measured in two cross-sectional population-based studies: Know Your Heart (KYH) (Russia, 2015–2018; n=4046) and the seventh wave of the Tromsø Study (Tromsø 7) (Norway, 2015–2018; n=17 646). A laboratory calibration study was performed to account for inter-laboratory differences. Results Levels of total, low-density lipoprotein-, high-density lipoprotein-cholesterol and triglycerides were comparable in KYH and Tromsø 7 studies. N-terminal pro-b-type natriuretic peptide (NT-proBNP), high-sensitivity cardiac troponin T (hs-cTnT) and high-sensitivity C-reactive protein (hsCRP) were higher in KYH compared with Tromsø 7 (NT-proBNP was higher by 54.1% (95% CI 41.5% to 67.8%) in men and by 30.8% (95% CI 22.9% to 39.2%) in women; hs-cTnT—by 42.4% (95% CI 36.1% to 49.0%) in men and by 68.1% (95% CI 62.4% to 73.9%) in women; hsCRP—by 33.3% (95% CI 26.1% to 40.8%) in men and by 35.6% (95% CI 29.0% to 42.6%) in women). Exclusion of participants with pre-existing coronary heart disease (279 men and 282 women) had no substantive effect. Conclusions Differences in cholesterol fractions cannot explain the difference in CVD mortality rate between Russia and Norway. A non-ischemic pathway to the cardiac damage reflected by raised NT-proBNP and hs-cTnT is likely to contribute to high CVD mortality in Russia. Text Tromsø HighWire Press (Stanford University) Norway Tromsø Journal of Epidemiology and Community Health jech-2020-213885 |
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HighWire Press (Stanford University) |
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fthighwire |
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English |
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Original research |
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Original research Lakunchykova, Olena Averina, Maria Wilsgaard, Tom Watkins, Hugh Malyutina, Sofia Ragino, Yulia Keogh, Ruth H Kudryavtsev, Alexander V Govorun, Vadim Cook, Sarah Schirmer, Henrik Eggen, Anne Elise Hopstock, Laila Arnesdatter Leon, David A Why does Russia have such high cardiovascular mortality rates? Comparisons of blood-based biomarkers with Norway implicate non-ischaemic cardiac damage |
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Original research |
description |
Background Russia has one of the highest rates of mortality from cardiovascular disease (CVD). At age 35–69 years, they are eight times higher than in neighbouring Norway. Comparing profiles of blood-based CVD biomarkers between these two populations can help identify reasons for this substantial difference in risk. Methods We compared age-standardised mean levels of CVD biomarkers for men and women aged 40–69 years measured in two cross-sectional population-based studies: Know Your Heart (KYH) (Russia, 2015–2018; n=4046) and the seventh wave of the Tromsø Study (Tromsø 7) (Norway, 2015–2018; n=17 646). A laboratory calibration study was performed to account for inter-laboratory differences. Results Levels of total, low-density lipoprotein-, high-density lipoprotein-cholesterol and triglycerides were comparable in KYH and Tromsø 7 studies. N-terminal pro-b-type natriuretic peptide (NT-proBNP), high-sensitivity cardiac troponin T (hs-cTnT) and high-sensitivity C-reactive protein (hsCRP) were higher in KYH compared with Tromsø 7 (NT-proBNP was higher by 54.1% (95% CI 41.5% to 67.8%) in men and by 30.8% (95% CI 22.9% to 39.2%) in women; hs-cTnT—by 42.4% (95% CI 36.1% to 49.0%) in men and by 68.1% (95% CI 62.4% to 73.9%) in women; hsCRP—by 33.3% (95% CI 26.1% to 40.8%) in men and by 35.6% (95% CI 29.0% to 42.6%) in women). Exclusion of participants with pre-existing coronary heart disease (279 men and 282 women) had no substantive effect. Conclusions Differences in cholesterol fractions cannot explain the difference in CVD mortality rate between Russia and Norway. A non-ischemic pathway to the cardiac damage reflected by raised NT-proBNP and hs-cTnT is likely to contribute to high CVD mortality in Russia. |
format |
Text |
author |
Lakunchykova, Olena Averina, Maria Wilsgaard, Tom Watkins, Hugh Malyutina, Sofia Ragino, Yulia Keogh, Ruth H Kudryavtsev, Alexander V Govorun, Vadim Cook, Sarah Schirmer, Henrik Eggen, Anne Elise Hopstock, Laila Arnesdatter Leon, David A |
author_facet |
Lakunchykova, Olena Averina, Maria Wilsgaard, Tom Watkins, Hugh Malyutina, Sofia Ragino, Yulia Keogh, Ruth H Kudryavtsev, Alexander V Govorun, Vadim Cook, Sarah Schirmer, Henrik Eggen, Anne Elise Hopstock, Laila Arnesdatter Leon, David A |
author_sort |
Lakunchykova, Olena |
title |
Why does Russia have such high cardiovascular mortality rates? Comparisons of blood-based biomarkers with Norway implicate non-ischaemic cardiac damage |
title_short |
Why does Russia have such high cardiovascular mortality rates? Comparisons of blood-based biomarkers with Norway implicate non-ischaemic cardiac damage |
title_full |
Why does Russia have such high cardiovascular mortality rates? Comparisons of blood-based biomarkers with Norway implicate non-ischaemic cardiac damage |
title_fullStr |
Why does Russia have such high cardiovascular mortality rates? Comparisons of blood-based biomarkers with Norway implicate non-ischaemic cardiac damage |
title_full_unstemmed |
Why does Russia have such high cardiovascular mortality rates? Comparisons of blood-based biomarkers with Norway implicate non-ischaemic cardiac damage |
title_sort |
why does russia have such high cardiovascular mortality rates? comparisons of blood-based biomarkers with norway implicate non-ischaemic cardiac damage |
publisher |
BMJ Publishing Group Ltd |
publishDate |
2020 |
url |
http://jech.bmj.com/cgi/content/short/74/9/698 https://doi.org/10.1136/jech-2020-213885 |
geographic |
Norway Tromsø |
geographic_facet |
Norway Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
http://jech.bmj.com/cgi/content/short/74/9/698 http://dx.doi.org/10.1136/jech-2020-213885 |
op_rights |
Copyright (C) 2020, BMJ Publishing Group Ltd |
op_doi |
https://doi.org/10.1136/jech-2020-213885 |
container_title |
Journal of Epidemiology and Community Health |
container_start_page |
jech-2020-213885 |
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1766218999014621184 |