Life course structural equation model of the effects of prenatal and postnatal growth on adult blood pressure
Background Fetal and postnatal growth have been associated with adult blood pressure (BP), but findings about the relative importance of growth at different stages of life on BP are inconsistent. Methods The study population comprised 5198 participants from the Northern Finland Birth Cohort 1966 wit...
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fthighwire:oai:open-archive.highwire.org:jech:68/12/1161 2023-05-15T17:42:37+02:00 Life course structural equation model of the effects of prenatal and postnatal growth on adult blood pressure Kaakinen, Marika Sovio, Ulla Hartikainen, Anna-Liisa Pouta, Anneli Savolainen, Markku J Herzig, Karl-Heinz Elliott, Paul De Stavola, Bianca Läärä, Esa Järvelin, Marjo-Riitta 2014-12-01 00:00:00.0 text/html http://jech.bmj.com/cgi/content/short/68/12/1161 https://doi.org/10.1136/jech-2013-203661 en eng BMJ Publishing Group Ltd http://jech.bmj.com/cgi/content/short/68/12/1161 http://dx.doi.org/10.1136/jech-2013-203661 Copyright (C) 2014, BMJ Publishing Group Ltd Other topics TEXT 2014 fthighwire https://doi.org/10.1136/jech-2013-203661 2015-02-28T23:07:44Z Background Fetal and postnatal growth have been associated with adult blood pressure (BP), but findings about the relative importance of growth at different stages of life on BP are inconsistent. Methods The study population comprised 5198 participants from the Northern Finland Birth Cohort 1966 with data on birth weight, height and weight measurements until adolescence, systolic and diastolic BP at 31 years and several covariates. Structural equation modelling was used in the analysis. Results Negative direct effects of birth weight on adult systolic BP were observed (standardised regression coefficients: −0.08 (−0.14 to −0.03) in males and −0.04 (−0.09 to 0.01) in females, equalling −1.99 (−3.32 to −0.65) and −1.01 (−2.33 to 0.32) mm Hg/kg, respectively). Immediate postnatal growth was associated with adult BP only indirectly via growth later in life. In contrast, growth from adiposity rebound onwards had large direct, indirect and total effects on adult BP. Current body mass index was the strongest growth-related predictor of adult BP (0.36 (0.30 to 0.41) in males and 0.31 (0.24, 0.37) in females, equalling 1.29 (1.09 to 1.48) and 0.81 (0.63 to 0.99) mm Hg/(kg/m2), respectively). Conclusions Our path analytical approach provides evidence for the importance of both fetal growth and postnatal growth, especially from adiposity rebound onwards, in determining adult BP, together with genetic predisposition and behavioural factors. Text Northern Finland HighWire Press (Stanford University) Journal of Epidemiology and Community Health 68 12 1161 1167 |
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Other topics Kaakinen, Marika Sovio, Ulla Hartikainen, Anna-Liisa Pouta, Anneli Savolainen, Markku J Herzig, Karl-Heinz Elliott, Paul De Stavola, Bianca Läärä, Esa Järvelin, Marjo-Riitta Life course structural equation model of the effects of prenatal and postnatal growth on adult blood pressure |
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description |
Background Fetal and postnatal growth have been associated with adult blood pressure (BP), but findings about the relative importance of growth at different stages of life on BP are inconsistent. Methods The study population comprised 5198 participants from the Northern Finland Birth Cohort 1966 with data on birth weight, height and weight measurements until adolescence, systolic and diastolic BP at 31 years and several covariates. Structural equation modelling was used in the analysis. Results Negative direct effects of birth weight on adult systolic BP were observed (standardised regression coefficients: −0.08 (−0.14 to −0.03) in males and −0.04 (−0.09 to 0.01) in females, equalling −1.99 (−3.32 to −0.65) and −1.01 (−2.33 to 0.32) mm Hg/kg, respectively). Immediate postnatal growth was associated with adult BP only indirectly via growth later in life. In contrast, growth from adiposity rebound onwards had large direct, indirect and total effects on adult BP. Current body mass index was the strongest growth-related predictor of adult BP (0.36 (0.30 to 0.41) in males and 0.31 (0.24, 0.37) in females, equalling 1.29 (1.09 to 1.48) and 0.81 (0.63 to 0.99) mm Hg/(kg/m2), respectively). Conclusions Our path analytical approach provides evidence for the importance of both fetal growth and postnatal growth, especially from adiposity rebound onwards, in determining adult BP, together with genetic predisposition and behavioural factors. |
format |
Text |
author |
Kaakinen, Marika Sovio, Ulla Hartikainen, Anna-Liisa Pouta, Anneli Savolainen, Markku J Herzig, Karl-Heinz Elliott, Paul De Stavola, Bianca Läärä, Esa Järvelin, Marjo-Riitta |
author_facet |
Kaakinen, Marika Sovio, Ulla Hartikainen, Anna-Liisa Pouta, Anneli Savolainen, Markku J Herzig, Karl-Heinz Elliott, Paul De Stavola, Bianca Läärä, Esa Järvelin, Marjo-Riitta |
author_sort |
Kaakinen, Marika |
title |
Life course structural equation model of the effects of prenatal and postnatal growth on adult blood pressure |
title_short |
Life course structural equation model of the effects of prenatal and postnatal growth on adult blood pressure |
title_full |
Life course structural equation model of the effects of prenatal and postnatal growth on adult blood pressure |
title_fullStr |
Life course structural equation model of the effects of prenatal and postnatal growth on adult blood pressure |
title_full_unstemmed |
Life course structural equation model of the effects of prenatal and postnatal growth on adult blood pressure |
title_sort |
life course structural equation model of the effects of prenatal and postnatal growth on adult blood pressure |
publisher |
BMJ Publishing Group Ltd |
publishDate |
2014 |
url |
http://jech.bmj.com/cgi/content/short/68/12/1161 https://doi.org/10.1136/jech-2013-203661 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_relation |
http://jech.bmj.com/cgi/content/short/68/12/1161 http://dx.doi.org/10.1136/jech-2013-203661 |
op_rights |
Copyright (C) 2014, BMJ Publishing Group Ltd |
op_doi |
https://doi.org/10.1136/jech-2013-203661 |
container_title |
Journal of Epidemiology and Community Health |
container_volume |
68 |
container_issue |
12 |
container_start_page |
1161 |
op_container_end_page |
1167 |
_version_ |
1766144505532121088 |