Influence of population density on antibiotic resistance
Antibiotic consumption and population density as a measure of crowding in the community were related to the prevalence of antibiotic resistance of three cities in three different countries: St Johns in Newfoundland (Canada), Athens in Greece and Groningen in The Netherlands. Antibiotic consumption w...
Published in: | Journal of Antimicrobial Chemotherapy |
---|---|
Main Authors: | , , , , , |
Format: | Text |
Language: | English |
Published: |
Oxford University Press
2003
|
Subjects: | |
Online Access: | http://jac.oxfordjournals.org/cgi/content/short/51/2/385 https://doi.org/10.1093/jac/dkg072 |
id |
fthighwire:oai:open-archive.highwire.org:jac:51/2/385 |
---|---|
record_format |
openpolar |
spelling |
fthighwire:oai:open-archive.highwire.org:jac:51/2/385 2023-05-15T17:20:16+02:00 Influence of population density on antibiotic resistance Bruinsma, N. Hutchinson, J. M. van den Bogaard, A. E. Giamarellou, H. Degener, J. Stobberingh, E. E. 2003-02-01 00:00:00.0 text/html http://jac.oxfordjournals.org/cgi/content/short/51/2/385 https://doi.org/10.1093/jac/dkg072 en eng Oxford University Press http://jac.oxfordjournals.org/cgi/content/short/51/2/385 http://dx.doi.org/10.1093/jac/dkg072 Copyright (C) 2003, The British Society for Antimicrobial Chemotherapy Antimicrobial practice TEXT 2003 fthighwire https://doi.org/10.1093/jac/dkg072 2007-06-24T07:28:08Z Antibiotic consumption and population density as a measure of crowding in the community were related to the prevalence of antibiotic resistance of three cities in three different countries: St Johns in Newfoundland (Canada), Athens in Greece and Groningen in The Netherlands. Antibiotic consumption was expressed in DDD (defined daily dose), as DID (DDD/1000 inhabitants/day) and as DSD (DDD/km2). The prevalence of antibiotic-resistant Escherichia coli and enterococci was determined in faecal samples of healthy volunteers. In both Newfoundland (28 DID) and Greece (29 DID) the overall consumption of antibiotics was more than three times higher compared with that of The Netherlands (9 DID). The lowest prevalence of resistant E. coli against the majority of antibiotics tested was found for the samples from Newfoundland and was significant ( P < 0.05) for cefazolin, oxytetracycline and trimethoprim. A poor correlation between the number of DID and the prevalence of resistance was observed [the Pearson correlation coefficient (Pcc) ranged between –0.93 and 0.87]. However, when population density was taken into consideration and antibiotic consumption was expressed in DSD, a strong correlation was observed (and Pcc ranged between 0.86 and 1.00). This study suggests that population density is an important factor in the development of antibiotic resistance and warrants special attention as a factor in resistance epidemiology. Text Newfoundland HighWire Press (Stanford University) Canada Journal of Antimicrobial Chemotherapy 51 2 385 390 |
institution |
Open Polar |
collection |
HighWire Press (Stanford University) |
op_collection_id |
fthighwire |
language |
English |
topic |
Antimicrobial practice |
spellingShingle |
Antimicrobial practice Bruinsma, N. Hutchinson, J. M. van den Bogaard, A. E. Giamarellou, H. Degener, J. Stobberingh, E. E. Influence of population density on antibiotic resistance |
topic_facet |
Antimicrobial practice |
description |
Antibiotic consumption and population density as a measure of crowding in the community were related to the prevalence of antibiotic resistance of three cities in three different countries: St Johns in Newfoundland (Canada), Athens in Greece and Groningen in The Netherlands. Antibiotic consumption was expressed in DDD (defined daily dose), as DID (DDD/1000 inhabitants/day) and as DSD (DDD/km2). The prevalence of antibiotic-resistant Escherichia coli and enterococci was determined in faecal samples of healthy volunteers. In both Newfoundland (28 DID) and Greece (29 DID) the overall consumption of antibiotics was more than three times higher compared with that of The Netherlands (9 DID). The lowest prevalence of resistant E. coli against the majority of antibiotics tested was found for the samples from Newfoundland and was significant ( P < 0.05) for cefazolin, oxytetracycline and trimethoprim. A poor correlation between the number of DID and the prevalence of resistance was observed [the Pearson correlation coefficient (Pcc) ranged between –0.93 and 0.87]. However, when population density was taken into consideration and antibiotic consumption was expressed in DSD, a strong correlation was observed (and Pcc ranged between 0.86 and 1.00). This study suggests that population density is an important factor in the development of antibiotic resistance and warrants special attention as a factor in resistance epidemiology. |
format |
Text |
author |
Bruinsma, N. Hutchinson, J. M. van den Bogaard, A. E. Giamarellou, H. Degener, J. Stobberingh, E. E. |
author_facet |
Bruinsma, N. Hutchinson, J. M. van den Bogaard, A. E. Giamarellou, H. Degener, J. Stobberingh, E. E. |
author_sort |
Bruinsma, N. |
title |
Influence of population density on antibiotic resistance |
title_short |
Influence of population density on antibiotic resistance |
title_full |
Influence of population density on antibiotic resistance |
title_fullStr |
Influence of population density on antibiotic resistance |
title_full_unstemmed |
Influence of population density on antibiotic resistance |
title_sort |
influence of population density on antibiotic resistance |
publisher |
Oxford University Press |
publishDate |
2003 |
url |
http://jac.oxfordjournals.org/cgi/content/short/51/2/385 https://doi.org/10.1093/jac/dkg072 |
geographic |
Canada |
geographic_facet |
Canada |
genre |
Newfoundland |
genre_facet |
Newfoundland |
op_relation |
http://jac.oxfordjournals.org/cgi/content/short/51/2/385 http://dx.doi.org/10.1093/jac/dkg072 |
op_rights |
Copyright (C) 2003, The British Society for Antimicrobial Chemotherapy |
op_doi |
https://doi.org/10.1093/jac/dkg072 |
container_title |
Journal of Antimicrobial Chemotherapy |
container_volume |
51 |
container_issue |
2 |
container_start_page |
385 |
op_container_end_page |
390 |
_version_ |
1766098606236893184 |