Abdominal aortic aneurysms, or a relatively large diameter of non-aneurysmal aortas, increase total and cardiovascular mortality: the Tromso study
Background In a population-based study in Tromsø, Norway, the authors assessed whether an abdominal aortic aneurysm (AAA) or the maximal infrarenal aortic diameter in a non-aneurismal aorta influence total and cardiovascular disease (CVD) mortality. Methods A total of 6640 men and women, aged 25–84...
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fthighwire:oai:open-archive.highwire.org:intjepid:dyp320v2 2023-05-15T18:33:53+02:00 Abdominal aortic aneurysms, or a relatively large diameter of non-aneurysmal aortas, increase total and cardiovascular mortality: the Tromso study Forsdahl, Signe Helene Solberg, Steinar Singh, Kulbir Jacobsen, Bjarne K 2009-11-12 06:42:21.0 text/html http://ije.oxfordjournals.org/cgi/content/short/dyp320v2 https://doi.org/10.1093/ije/dyp320 en eng Oxford University Press http://ije.oxfordjournals.org/cgi/content/short/dyp320v2 http://dx.doi.org/10.1093/ije/dyp320 Copyright (C) 2009, International Epidemiological Association Original Paper TEXT 2009 fthighwire https://doi.org/10.1093/ije/dyp320 2013-05-27T14:59:16Z Background In a population-based study in Tromsø, Norway, the authors assessed whether an abdominal aortic aneurysm (AAA) or the maximal infrarenal aortic diameter in a non-aneurismal aorta influence total and cardiovascular disease (CVD) mortality. Methods A total of 6640 men and women, aged 25–84 years, were included in a 10-year mortality follow-up: 345 subjects with a diagnosed AAA and 6295 subjects with a non-aneurismal aorta. Non-aneurismal aortic diameter and prevalent AAAs were categorized into seven groups. Results In subjects without an AAA, an aortic diameter ≥30 mm increased age- and sex-adjusted total mortality [mortality rate ratio (MRR) = 3.73, 95% confidence interval (CI) 1.77–7.89] and CVD mortality (MRR = 9.24, 95% CI 4.07–20.97) compared with subjects with aortic diameter of 21–23 mm. An AAA at screening was strongly associated with deaths from aortic aneurysm and was associated with total (MRR = 1.60, 95% CI 1.31–1.96) and CVD mortality (MRR = 2.41, 95% CI 1.81–3.21). This was not explained by deaths due to an AAA. Adjustments for CVD risk factors could fully explain the increased total, but not CVD mortality in subjects with an AAA. Conclusions An AAA increases total and CVD mortality. In the large majority of subjects with a non-aneurysmal aorta, the diameter does not influence total or CVD mortality. However, in individuals with a maximal diameter >26 mm (2% of the population), a positive relationship is found. Text Tromso Tromso Tromsø HighWire Press (Stanford University) Norway Tromsø Tromso ENVELOPE(16.546,16.546,68.801,68.801) International Journal of Epidemiology 39 1 225 232 |
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English |
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Original Paper |
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Original Paper Forsdahl, Signe Helene Solberg, Steinar Singh, Kulbir Jacobsen, Bjarne K Abdominal aortic aneurysms, or a relatively large diameter of non-aneurysmal aortas, increase total and cardiovascular mortality: the Tromso study |
topic_facet |
Original Paper |
description |
Background In a population-based study in Tromsø, Norway, the authors assessed whether an abdominal aortic aneurysm (AAA) or the maximal infrarenal aortic diameter in a non-aneurismal aorta influence total and cardiovascular disease (CVD) mortality. Methods A total of 6640 men and women, aged 25–84 years, were included in a 10-year mortality follow-up: 345 subjects with a diagnosed AAA and 6295 subjects with a non-aneurismal aorta. Non-aneurismal aortic diameter and prevalent AAAs were categorized into seven groups. Results In subjects without an AAA, an aortic diameter ≥30 mm increased age- and sex-adjusted total mortality [mortality rate ratio (MRR) = 3.73, 95% confidence interval (CI) 1.77–7.89] and CVD mortality (MRR = 9.24, 95% CI 4.07–20.97) compared with subjects with aortic diameter of 21–23 mm. An AAA at screening was strongly associated with deaths from aortic aneurysm and was associated with total (MRR = 1.60, 95% CI 1.31–1.96) and CVD mortality (MRR = 2.41, 95% CI 1.81–3.21). This was not explained by deaths due to an AAA. Adjustments for CVD risk factors could fully explain the increased total, but not CVD mortality in subjects with an AAA. Conclusions An AAA increases total and CVD mortality. In the large majority of subjects with a non-aneurysmal aorta, the diameter does not influence total or CVD mortality. However, in individuals with a maximal diameter >26 mm (2% of the population), a positive relationship is found. |
format |
Text |
author |
Forsdahl, Signe Helene Solberg, Steinar Singh, Kulbir Jacobsen, Bjarne K |
author_facet |
Forsdahl, Signe Helene Solberg, Steinar Singh, Kulbir Jacobsen, Bjarne K |
author_sort |
Forsdahl, Signe Helene |
title |
Abdominal aortic aneurysms, or a relatively large diameter of non-aneurysmal aortas, increase total and cardiovascular mortality: the Tromso study |
title_short |
Abdominal aortic aneurysms, or a relatively large diameter of non-aneurysmal aortas, increase total and cardiovascular mortality: the Tromso study |
title_full |
Abdominal aortic aneurysms, or a relatively large diameter of non-aneurysmal aortas, increase total and cardiovascular mortality: the Tromso study |
title_fullStr |
Abdominal aortic aneurysms, or a relatively large diameter of non-aneurysmal aortas, increase total and cardiovascular mortality: the Tromso study |
title_full_unstemmed |
Abdominal aortic aneurysms, or a relatively large diameter of non-aneurysmal aortas, increase total and cardiovascular mortality: the Tromso study |
title_sort |
abdominal aortic aneurysms, or a relatively large diameter of non-aneurysmal aortas, increase total and cardiovascular mortality: the tromso study |
publisher |
Oxford University Press |
publishDate |
2009 |
url |
http://ije.oxfordjournals.org/cgi/content/short/dyp320v2 https://doi.org/10.1093/ije/dyp320 |
long_lat |
ENVELOPE(16.546,16.546,68.801,68.801) |
geographic |
Norway Tromsø Tromso |
geographic_facet |
Norway Tromsø Tromso |
genre |
Tromso Tromso Tromsø |
genre_facet |
Tromso Tromso Tromsø |
op_relation |
http://ije.oxfordjournals.org/cgi/content/short/dyp320v2 http://dx.doi.org/10.1093/ije/dyp320 |
op_rights |
Copyright (C) 2009, International Epidemiological Association |
op_doi |
https://doi.org/10.1093/ije/dyp320 |
container_title |
International Journal of Epidemiology |
container_volume |
39 |
container_issue |
1 |
container_start_page |
225 |
op_container_end_page |
232 |
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1766218510128644096 |