Osteoprotegerin is associated with hip fracture incidence: the Tromso Study
Background Osteoprotegerin (OPG) is a cytokine essential for the regulation of bone resorption, but large longitudinal studies on its relationship to fracture risk in humans are lacking. In this population-based study of 2740 men and 2857 post-menopausal women, it was examined whether serum OPG was...
Published in: | International Journal of Epidemiology |
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fthighwire:oai:open-archive.highwire.org:intjepid:41/4/1033 2023-05-15T18:33:52+02:00 Osteoprotegerin is associated with hip fracture incidence: the Tromso Study Jørgensen, Lone Hansen, John-Bjarne Ahmed, Luai Bjørnerem, Åshild Emaus, Nina Joakimsen, Ragnar Mathiesen, Ellisiv Størmer, Jan Vik, Anders Jacobsen, Bjarne K 2012-08-01 00:00:00.0 text/html http://ije.oxfordjournals.org/cgi/content/short/41/4/1033 https://doi.org/10.1093/ije/dys063 en eng Oxford University Press http://ije.oxfordjournals.org/cgi/content/short/41/4/1033 http://dx.doi.org/10.1093/ije/dys063 Copyright (C) 2012, International Epidemiological Association Ageing TEXT 2012 fthighwire https://doi.org/10.1093/ije/dys063 2016-11-16T17:38:34Z Background Osteoprotegerin (OPG) is a cytokine essential for the regulation of bone resorption, but large longitudinal studies on its relationship to fracture risk in humans are lacking. In this population-based study of 2740 men and 2857 post-menopausal women, it was examined whether serum OPG was associated with hip fracture incidence. The participants were followed for 15 years. Methods Baseline measurements included height, weight and serum OPG, and information about lifestyle, prevalent diseases and use of medication. Results Men with OPG in the highest quartile were 2.79-fold [95% confidence interval (CI) 1.34–5.82] more likely to have a hip fracture during follow-up, compared with those with OPG in the lowest quartile ( P- trend over OPG quartiles ≤0.001, after adjustments for age and other confounders). In women not using post-menopausal hormone therapy (HT), the risk of hip fracture was 1.64-fold higher (95% CI 0.94–2.86) in the highest quartile compared with the lowest OPG quartile ( P- trend over OPG quartiles = 0.05). No relationship was found in post-menopausal women using HT ( P- trend over OPG quartiles = 0.23). Conclusions In men, OPG was positively associated with the incidence of hip fracture. In post-menopausal women not using HT a similar, but weaker, relationship was found. Text Tromso Tromso HighWire Press (Stanford University) Tromso ENVELOPE(16.546,16.546,68.801,68.801) International Journal of Epidemiology 41 4 1033 1039 |
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Ageing Jørgensen, Lone Hansen, John-Bjarne Ahmed, Luai Bjørnerem, Åshild Emaus, Nina Joakimsen, Ragnar Mathiesen, Ellisiv Størmer, Jan Vik, Anders Jacobsen, Bjarne K Osteoprotegerin is associated with hip fracture incidence: the Tromso Study |
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Ageing |
description |
Background Osteoprotegerin (OPG) is a cytokine essential for the regulation of bone resorption, but large longitudinal studies on its relationship to fracture risk in humans are lacking. In this population-based study of 2740 men and 2857 post-menopausal women, it was examined whether serum OPG was associated with hip fracture incidence. The participants were followed for 15 years. Methods Baseline measurements included height, weight and serum OPG, and information about lifestyle, prevalent diseases and use of medication. Results Men with OPG in the highest quartile were 2.79-fold [95% confidence interval (CI) 1.34–5.82] more likely to have a hip fracture during follow-up, compared with those with OPG in the lowest quartile ( P- trend over OPG quartiles ≤0.001, after adjustments for age and other confounders). In women not using post-menopausal hormone therapy (HT), the risk of hip fracture was 1.64-fold higher (95% CI 0.94–2.86) in the highest quartile compared with the lowest OPG quartile ( P- trend over OPG quartiles = 0.05). No relationship was found in post-menopausal women using HT ( P- trend over OPG quartiles = 0.23). Conclusions In men, OPG was positively associated with the incidence of hip fracture. In post-menopausal women not using HT a similar, but weaker, relationship was found. |
format |
Text |
author |
Jørgensen, Lone Hansen, John-Bjarne Ahmed, Luai Bjørnerem, Åshild Emaus, Nina Joakimsen, Ragnar Mathiesen, Ellisiv Størmer, Jan Vik, Anders Jacobsen, Bjarne K |
author_facet |
Jørgensen, Lone Hansen, John-Bjarne Ahmed, Luai Bjørnerem, Åshild Emaus, Nina Joakimsen, Ragnar Mathiesen, Ellisiv Størmer, Jan Vik, Anders Jacobsen, Bjarne K |
author_sort |
Jørgensen, Lone |
title |
Osteoprotegerin is associated with hip fracture incidence: the Tromso Study |
title_short |
Osteoprotegerin is associated with hip fracture incidence: the Tromso Study |
title_full |
Osteoprotegerin is associated with hip fracture incidence: the Tromso Study |
title_fullStr |
Osteoprotegerin is associated with hip fracture incidence: the Tromso Study |
title_full_unstemmed |
Osteoprotegerin is associated with hip fracture incidence: the Tromso Study |
title_sort |
osteoprotegerin is associated with hip fracture incidence: the tromso study |
publisher |
Oxford University Press |
publishDate |
2012 |
url |
http://ije.oxfordjournals.org/cgi/content/short/41/4/1033 https://doi.org/10.1093/ije/dys063 |
long_lat |
ENVELOPE(16.546,16.546,68.801,68.801) |
geographic |
Tromso |
geographic_facet |
Tromso |
genre |
Tromso Tromso |
genre_facet |
Tromso Tromso |
op_relation |
http://ije.oxfordjournals.org/cgi/content/short/41/4/1033 http://dx.doi.org/10.1093/ije/dys063 |
op_rights |
Copyright (C) 2012, International Epidemiological Association |
op_doi |
https://doi.org/10.1093/ije/dys063 |
container_title |
International Journal of Epidemiology |
container_volume |
41 |
container_issue |
4 |
container_start_page |
1033 |
op_container_end_page |
1039 |
_version_ |
1766218499499229184 |