Smoking during pregnancy and hyperactivity-inattention in the offspring--comparing results from three Nordic cohorts
Background Prenatal exposure to smoking has been associated with Attention Deficit Hyperactivity Disorder (ADHD) in a number of epidemiological studies. However, mothers with the ADHD phenotype may ‘treat’ their problem by smoking and therefore be more likely to smoke even in a society where smoking...
Published in: | International Journal of Epidemiology |
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fthighwire:oai:open-archive.highwire.org:intjepid:38/3/698 2023-05-15T17:42:40+02:00 Smoking during pregnancy and hyperactivity-inattention in the offspring--comparing results from three Nordic cohorts Obel, Carsten Linnet, Karen Markussen Henriksen, Tine Brink Rodriguez, Alina Järvelin, Marjo Riita Kotimaa, Arto Moilanen, Irma Ebeling, Hanna Bilenberg, Niels Taanila, Anja Ye, Gan Olsen, Jørn 2009-06-01 00:00:00.0 text/html http://ije.oxfordjournals.org/cgi/content/short/38/3/698 https://doi.org/10.1093/ije/dym290 en eng Oxford University Press http://ije.oxfordjournals.org/cgi/content/short/38/3/698 http://dx.doi.org/10.1093/ije/dym290 Copyright (C) 2009, International Epidemiological Association Intergenerational Influences on Health TEXT 2009 fthighwire https://doi.org/10.1093/ije/dym290 2016-11-16T18:57:09Z Background Prenatal exposure to smoking has been associated with Attention Deficit Hyperactivity Disorder (ADHD) in a number of epidemiological studies. However, mothers with the ADHD phenotype may ‘treat’ their problem by smoking and therefore be more likely to smoke even in a society where smoking is not acceptable. This will cause genetic confounding if ADHD has a heritable component, especially in populations with low prevalence rates of smoking since this reason for smoking is expected to be proportionally more frequent in a population with few ‘normal’ smokers. We compared the association in cohorts with different smoking frequencies. Methods A total of 20 936 women with singleton pregnancies were identified within three population-based pregnancy cohorts in Northern Finland (1985–1986) and in Denmark (1984–1987 and 1989–1991). We collected self-reported data on their pre-pregnancy and pregnancy smoking habits and followed the children to school age where teachers and parents rated hyperactivity and inattention symptoms. Results Children, whose mothers smoked during pregnancy, had an increased prevalence of a high hyperactivity-inattention score compared with children of nonsmokers in each of the cohorts after adjustment for confounders but we found no statistical significant difference between the associations across the cohorts. Conclusion The estimated association was not strongest in the population with the fewest smokers which does not support the hypothesis that the association is entirely due to genetic confounding. Text Northern Finland HighWire Press (Stanford University) International Journal of Epidemiology 38 3 698 705 |
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HighWire Press (Stanford University) |
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English |
topic |
Intergenerational Influences on Health |
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Intergenerational Influences on Health Obel, Carsten Linnet, Karen Markussen Henriksen, Tine Brink Rodriguez, Alina Järvelin, Marjo Riita Kotimaa, Arto Moilanen, Irma Ebeling, Hanna Bilenberg, Niels Taanila, Anja Ye, Gan Olsen, Jørn Smoking during pregnancy and hyperactivity-inattention in the offspring--comparing results from three Nordic cohorts |
topic_facet |
Intergenerational Influences on Health |
description |
Background Prenatal exposure to smoking has been associated with Attention Deficit Hyperactivity Disorder (ADHD) in a number of epidemiological studies. However, mothers with the ADHD phenotype may ‘treat’ their problem by smoking and therefore be more likely to smoke even in a society where smoking is not acceptable. This will cause genetic confounding if ADHD has a heritable component, especially in populations with low prevalence rates of smoking since this reason for smoking is expected to be proportionally more frequent in a population with few ‘normal’ smokers. We compared the association in cohorts with different smoking frequencies. Methods A total of 20 936 women with singleton pregnancies were identified within three population-based pregnancy cohorts in Northern Finland (1985–1986) and in Denmark (1984–1987 and 1989–1991). We collected self-reported data on their pre-pregnancy and pregnancy smoking habits and followed the children to school age where teachers and parents rated hyperactivity and inattention symptoms. Results Children, whose mothers smoked during pregnancy, had an increased prevalence of a high hyperactivity-inattention score compared with children of nonsmokers in each of the cohorts after adjustment for confounders but we found no statistical significant difference between the associations across the cohorts. Conclusion The estimated association was not strongest in the population with the fewest smokers which does not support the hypothesis that the association is entirely due to genetic confounding. |
format |
Text |
author |
Obel, Carsten Linnet, Karen Markussen Henriksen, Tine Brink Rodriguez, Alina Järvelin, Marjo Riita Kotimaa, Arto Moilanen, Irma Ebeling, Hanna Bilenberg, Niels Taanila, Anja Ye, Gan Olsen, Jørn |
author_facet |
Obel, Carsten Linnet, Karen Markussen Henriksen, Tine Brink Rodriguez, Alina Järvelin, Marjo Riita Kotimaa, Arto Moilanen, Irma Ebeling, Hanna Bilenberg, Niels Taanila, Anja Ye, Gan Olsen, Jørn |
author_sort |
Obel, Carsten |
title |
Smoking during pregnancy and hyperactivity-inattention in the offspring--comparing results from three Nordic cohorts |
title_short |
Smoking during pregnancy and hyperactivity-inattention in the offspring--comparing results from three Nordic cohorts |
title_full |
Smoking during pregnancy and hyperactivity-inattention in the offspring--comparing results from three Nordic cohorts |
title_fullStr |
Smoking during pregnancy and hyperactivity-inattention in the offspring--comparing results from three Nordic cohorts |
title_full_unstemmed |
Smoking during pregnancy and hyperactivity-inattention in the offspring--comparing results from three Nordic cohorts |
title_sort |
smoking during pregnancy and hyperactivity-inattention in the offspring--comparing results from three nordic cohorts |
publisher |
Oxford University Press |
publishDate |
2009 |
url |
http://ije.oxfordjournals.org/cgi/content/short/38/3/698 https://doi.org/10.1093/ije/dym290 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_relation |
http://ije.oxfordjournals.org/cgi/content/short/38/3/698 http://dx.doi.org/10.1093/ije/dym290 |
op_rights |
Copyright (C) 2009, International Epidemiological Association |
op_doi |
https://doi.org/10.1093/ije/dym290 |
container_title |
International Journal of Epidemiology |
container_volume |
38 |
container_issue |
3 |
container_start_page |
698 |
op_container_end_page |
705 |
_version_ |
1766144565096480768 |