Regular Leisure Time Physical Activity Predicts High Activity of Tissue Plasminogen Activator: The Northern Sweden MONICA Study
Eliasson M (Department of Medicine, Lule� Hospital, S-971 25 Lule�, Sweden), Asplund K and Evrin P-E. Regular leisure time physical activity predicts high activity of tissue plasminogen activator: The Northern Sweden MONICA Study. International Journal of Epidemiology 1996; 25: 1182–1188. Background...
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fthighwire:oai:open-archive.highwire.org:intjepid:25/6/1182 2023-05-15T17:44:30+02:00 Regular Leisure Time Physical Activity Predicts High Activity of Tissue Plasminogen Activator: The Northern Sweden MONICA Study ELIASSON, MATS ASPLUND, KJELL EVRIN, PER-ERIC 1996-12-01 00:00:00.0 text/html http://ije.oxfordjournals.org/cgi/content/short/25/6/1182 https://doi.org/10.1093/ije/25.6.1182 en eng Oxford University Press http://ije.oxfordjournals.org/cgi/content/short/25/6/1182 http://dx.doi.org/10.1093/ije/25.6.1182 Copyright (C) 1996, International Epidemiological Association Original Articles TEXT 1996 fthighwire https://doi.org/10.1093/ije/25.6.1182 2015-02-28T21:15:14Z Eliasson M (Department of Medicine, Lule� Hospital, S-971 25 Lule�, Sweden), Asplund K and Evrin P-E. Regular leisure time physical activity predicts high activity of tissue plasminogen activator: The Northern Sweden MONICA Study. International Journal of Epidemiology 1996; 25: 1182–1188. Background Leisure time physical activity protects against the development of cardiovascular disease, partly by lowerIng blood pressure, cholesterol and body weight. Little is known about the effects of regular exercise on fibrinolytic variables in the population. Methods In a population sample of 733 men and 774 women aged 25–64 years physical activity during leisure time was related to fibrinolytic variables. Results The activity of tissue plasminogen activator (tPA) increased linearly with greater physical activity, the difference between sedentary and most active subjects being 28.9% in men and 11.6% in women. The tPA mass concentrations decreased by 27.4% and 28.0% in men and women respectively, as did also plasminogen activator inhibitor (PAI-1) activity; 38.5% and 30.6%. Tests for trend were significant ( P < 0.001) for all but tPA activity in women. Adjusting for age, body mass index and waist hip ratio only slightly decreased these relationships. When taking tnglyceride into account, tPA activity and PAI-1 activity (in men) were no longer significantly related to physical activity level but lower tPA mass concentrations and PAI-1 activity (in women) were still found in those who exercised regularly Further adjustment for insulin levels abolished all differences, except for PAI-1 activity in women. Conclusion Greater leisure time physical activity is associated with an increased fibrinolytic activity. This may contribute to less cardiovascular disease in subjects who exercise regularly. Text Northern Sweden HighWire Press (Stanford University) International Journal of Epidemiology 25 6 1182 1188 |
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Original Articles ELIASSON, MATS ASPLUND, KJELL EVRIN, PER-ERIC Regular Leisure Time Physical Activity Predicts High Activity of Tissue Plasminogen Activator: The Northern Sweden MONICA Study |
topic_facet |
Original Articles |
description |
Eliasson M (Department of Medicine, Lule� Hospital, S-971 25 Lule�, Sweden), Asplund K and Evrin P-E. Regular leisure time physical activity predicts high activity of tissue plasminogen activator: The Northern Sweden MONICA Study. International Journal of Epidemiology 1996; 25: 1182–1188. Background Leisure time physical activity protects against the development of cardiovascular disease, partly by lowerIng blood pressure, cholesterol and body weight. Little is known about the effects of regular exercise on fibrinolytic variables in the population. Methods In a population sample of 733 men and 774 women aged 25–64 years physical activity during leisure time was related to fibrinolytic variables. Results The activity of tissue plasminogen activator (tPA) increased linearly with greater physical activity, the difference between sedentary and most active subjects being 28.9% in men and 11.6% in women. The tPA mass concentrations decreased by 27.4% and 28.0% in men and women respectively, as did also plasminogen activator inhibitor (PAI-1) activity; 38.5% and 30.6%. Tests for trend were significant ( P < 0.001) for all but tPA activity in women. Adjusting for age, body mass index and waist hip ratio only slightly decreased these relationships. When taking tnglyceride into account, tPA activity and PAI-1 activity (in men) were no longer significantly related to physical activity level but lower tPA mass concentrations and PAI-1 activity (in women) were still found in those who exercised regularly Further adjustment for insulin levels abolished all differences, except for PAI-1 activity in women. Conclusion Greater leisure time physical activity is associated with an increased fibrinolytic activity. This may contribute to less cardiovascular disease in subjects who exercise regularly. |
format |
Text |
author |
ELIASSON, MATS ASPLUND, KJELL EVRIN, PER-ERIC |
author_facet |
ELIASSON, MATS ASPLUND, KJELL EVRIN, PER-ERIC |
author_sort |
ELIASSON, MATS |
title |
Regular Leisure Time Physical Activity Predicts High Activity of Tissue Plasminogen Activator: The Northern Sweden MONICA Study |
title_short |
Regular Leisure Time Physical Activity Predicts High Activity of Tissue Plasminogen Activator: The Northern Sweden MONICA Study |
title_full |
Regular Leisure Time Physical Activity Predicts High Activity of Tissue Plasminogen Activator: The Northern Sweden MONICA Study |
title_fullStr |
Regular Leisure Time Physical Activity Predicts High Activity of Tissue Plasminogen Activator: The Northern Sweden MONICA Study |
title_full_unstemmed |
Regular Leisure Time Physical Activity Predicts High Activity of Tissue Plasminogen Activator: The Northern Sweden MONICA Study |
title_sort |
regular leisure time physical activity predicts high activity of tissue plasminogen activator: the northern sweden monica study |
publisher |
Oxford University Press |
publishDate |
1996 |
url |
http://ije.oxfordjournals.org/cgi/content/short/25/6/1182 https://doi.org/10.1093/ije/25.6.1182 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_relation |
http://ije.oxfordjournals.org/cgi/content/short/25/6/1182 http://dx.doi.org/10.1093/ije/25.6.1182 |
op_rights |
Copyright (C) 1996, International Epidemiological Association |
op_doi |
https://doi.org/10.1093/ije/25.6.1182 |
container_title |
International Journal of Epidemiology |
container_volume |
25 |
container_issue |
6 |
container_start_page |
1182 |
op_container_end_page |
1188 |
_version_ |
1766146728221736960 |