152 * GLOBAL TRENDS IN MORTALITY FROM THORACIC AORTIC DISEASE FROM 1995 TO 2010 AND CORRELATIONS WITH CARDIOVASCULAR RISK FACTORS

• Published in: Interactive CardioVascular and Thoracic Surgery
• Main Authors: Meduoye, A., Choke, E., Sidloff, D., Bown, M.J., Sayers, R.D., Murphy, G.J.
• Format: Text
• Language: English
• Published: Oxford University Press 2013
• Subjects: Cardiac potpourri; New Zealand; Norway; Iceland
• Online Access: http://icvts.oxfordjournals.org/cgi/content/short/17/suppl_2/S106-a; https://doi.org/10.1093/icvts/ivt372.152

Objectives: This study investigated global trends in mortality from thoracic aortic dissection (TAD) and aneurysm (TAA) and analysed for correlations with cardiovascular risk factors. Methods: Eighteen countries were investigated: Australia, Austria, Czech Republic, Denmark, Finland, France, Germany, Hungary, Iceland, Japan, Netherlands, New Zealand, Norway, Romania, Spain, Sweden, UK and USA. Age-standardized mortality (ASM) was calculated from World Health Organisation data. Cardiovascular risk factors (body mass index [BMI], systolic blood pressure [SBP], cholesterol and smoking prevalence) were correlated with ASM using multivariate regression. Results: Mean annual ASM (1995-2010) (deaths/100,000/year) from TAD and TAA was 1.8 (male) and 0.9 (female). Age-groups 60-84 and 30-60 contributed 65% and 25% of mortality respectively. Significant reductions in ASM were observed in 10 countries, significant increases in four. ASM in under 30s was unchanged. Linear correlations exist between rising BMI/falling cholesterol/falling SBP and trends in ASM from TAD/TAA in male (overall P = 0.13, R2 = 0.55, P > 0.05/ P = 0.003/ P > 0.05) and female (overall P = 0.00, R2 = 0.76, P = 0.01/ P = 0.003/ P > 0.05). Significant linear correlations were found between these risk factors and TAD alone: in male (overall P = 0.04, R2 = 0.62, P > 0.05/ P = 0.001/ P = 0.05) and female (overall P = 0.01, R2 = 0.73, P = 0.005/ P = 0.001/ P > 0.05). Correlations are noted with ruptured TAA alone: male (overall P = 0.09, R2 = 0.57, P > 0.05/ P = 0.006/ P > 0.05) and female (overall P = 0.24, R2 = 0.51, P = 0.042/ P = 0.021/ P > 0.05). There was no significant correlation with smoking. Conclusions: Globally, mortality due to thoracic aortic disease is falling, mirroring recently reported declining mortality from abdominal aortic aneurysms (AAA). Rising BMI, and decline in SBP and cholesterol correlated with mortality from thoracic aortic disease. Smoking did not correlate significantly, highlighting important ...