Exposure to PCB and p, p'-DDE in European and Inuit populations: impact on human sperm chromatin integrity
BACKGROUND: Persistent organochlorine pollutants (POP), such as polychlorinated biphenyls (PCB) and dichlorodiphenyldichloroethylene ( p , p ′ -DDE), are widely found in the environment and considered potential endocrine-disrupting compounds (EDC). Their impact on male fertility is still unknown. ME...
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fthighwire:oai:open-archive.highwire.org:humrep:20/12/3488 2023-05-15T16:29:28+02:00 Exposure to PCB and p, p'-DDE in European and Inuit populations: impact on human sperm chromatin integrity Spanò, M. Toft, G. Hagmar, L. Eleuteri, P. Rescia, M. Rignell-Hydbom, A. Tyrkiel, E. Zvyezday, V. Bonde, J.P. INUENDO 2005-12-01 00:00:00.0 text/html http://humrep.oxfordjournals.org/cgi/content/short/20/12/3488 https://doi.org/10.1093/humrep/dei297 en eng Oxford University Press http://humrep.oxfordjournals.org/cgi/content/short/20/12/3488 http://dx.doi.org/10.1093/humrep/dei297 Copyright (C) 2005, European Society of Human Reproduction and Embryology Andrology TEXT 2005 fthighwire https://doi.org/10.1093/humrep/dei297 2016-11-16T17:52:41Z BACKGROUND: Persistent organochlorine pollutants (POP), such as polychlorinated biphenyls (PCB) and dichlorodiphenyldichloroethylene ( p , p ′ -DDE), are widely found in the environment and considered potential endocrine-disrupting compounds (EDC). Their impact on male fertility is still unknown. METHODS: To explore the hypothesis that POP is associated with altered sperm chromatin integrity, a cross-sectional study involving 707 adult males (193 Inuits from Greenland, 178 Swedish fishermen, 141 men from Warsaw, Poland, and 195 men from Kharkiv, Ukraine) was carried out. Serum levels of 2,2 ′ ,4,4 ′ ,5,5 ′ -hexachlorobiphenyl (CB-153), as a proxy of the total PCB burden, and of p , p ′-DDE were determined. Sperm chromatin structure assay (SCSA) was used to assess sperm DNA/chromatin integrity. RESULTS: We found a strong and monotonically increasing DNA fragmentation index with increasing serum levels of CB-153 among European but not Inuit men, reaching a 60% higher average level in the highest exposure group. No significant associations were found between SCSA-derived parameters and p , p ′-DDE serum concentrations. CONCLUSION: These results suggest that human dietary PCB exposure might have a negative impact on the sperm chromatin integrity of adult males but additional issues, including differences in the genetic background and lifestyle habits, still need to be elucidated. Text Greenland inuit inuits HighWire Press (Stanford University) Greenland Human Reproduction 20 12 3488 3499 |
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Open Polar |
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HighWire Press (Stanford University) |
op_collection_id |
fthighwire |
language |
English |
topic |
Andrology |
spellingShingle |
Andrology Spanò, M. Toft, G. Hagmar, L. Eleuteri, P. Rescia, M. Rignell-Hydbom, A. Tyrkiel, E. Zvyezday, V. Bonde, J.P. INUENDO Exposure to PCB and p, p'-DDE in European and Inuit populations: impact on human sperm chromatin integrity |
topic_facet |
Andrology |
description |
BACKGROUND: Persistent organochlorine pollutants (POP), such as polychlorinated biphenyls (PCB) and dichlorodiphenyldichloroethylene ( p , p ′ -DDE), are widely found in the environment and considered potential endocrine-disrupting compounds (EDC). Their impact on male fertility is still unknown. METHODS: To explore the hypothesis that POP is associated with altered sperm chromatin integrity, a cross-sectional study involving 707 adult males (193 Inuits from Greenland, 178 Swedish fishermen, 141 men from Warsaw, Poland, and 195 men from Kharkiv, Ukraine) was carried out. Serum levels of 2,2 ′ ,4,4 ′ ,5,5 ′ -hexachlorobiphenyl (CB-153), as a proxy of the total PCB burden, and of p , p ′-DDE were determined. Sperm chromatin structure assay (SCSA) was used to assess sperm DNA/chromatin integrity. RESULTS: We found a strong and monotonically increasing DNA fragmentation index with increasing serum levels of CB-153 among European but not Inuit men, reaching a 60% higher average level in the highest exposure group. No significant associations were found between SCSA-derived parameters and p , p ′-DDE serum concentrations. CONCLUSION: These results suggest that human dietary PCB exposure might have a negative impact on the sperm chromatin integrity of adult males but additional issues, including differences in the genetic background and lifestyle habits, still need to be elucidated. |
format |
Text |
author |
Spanò, M. Toft, G. Hagmar, L. Eleuteri, P. Rescia, M. Rignell-Hydbom, A. Tyrkiel, E. Zvyezday, V. Bonde, J.P. INUENDO |
author_facet |
Spanò, M. Toft, G. Hagmar, L. Eleuteri, P. Rescia, M. Rignell-Hydbom, A. Tyrkiel, E. Zvyezday, V. Bonde, J.P. INUENDO |
author_sort |
Spanò, M. |
title |
Exposure to PCB and p, p'-DDE in European and Inuit populations: impact on human sperm chromatin integrity |
title_short |
Exposure to PCB and p, p'-DDE in European and Inuit populations: impact on human sperm chromatin integrity |
title_full |
Exposure to PCB and p, p'-DDE in European and Inuit populations: impact on human sperm chromatin integrity |
title_fullStr |
Exposure to PCB and p, p'-DDE in European and Inuit populations: impact on human sperm chromatin integrity |
title_full_unstemmed |
Exposure to PCB and p, p'-DDE in European and Inuit populations: impact on human sperm chromatin integrity |
title_sort |
exposure to pcb and p, p'-dde in european and inuit populations: impact on human sperm chromatin integrity |
publisher |
Oxford University Press |
publishDate |
2005 |
url |
http://humrep.oxfordjournals.org/cgi/content/short/20/12/3488 https://doi.org/10.1093/humrep/dei297 |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
Greenland inuit inuits |
genre_facet |
Greenland inuit inuits |
op_relation |
http://humrep.oxfordjournals.org/cgi/content/short/20/12/3488 http://dx.doi.org/10.1093/humrep/dei297 |
op_rights |
Copyright (C) 2005, European Society of Human Reproduction and Embryology |
op_doi |
https://doi.org/10.1093/humrep/dei297 |
container_title |
Human Reproduction |
container_volume |
20 |
container_issue |
12 |
container_start_page |
3488 |
op_container_end_page |
3499 |
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1766019169010057216 |