Genetic factors contribute to the risk of developing endometriosis
BACKGROUND: Endometriosis is known to cluster within nuclear families. The extent of familial clustering can be evaluated in Iceland with its large population-based genealogical database. METHODS AND RESULTS: Applying several measures of familiality we demonstrated that 750 women with endometriosis...
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2002
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fthighwire:oai:open-archive.highwire.org:humrep:17/3/555 2023-05-15T16:50:36+02:00 Genetic factors contribute to the risk of developing endometriosis Stefansson, H. Geirsson, R.T. Steinthorsdottir, V. Jonsson, H. Manolescu, A. Kong, A. Ingadottir, G. Gulcher, J. Stefansson, K. 2002-03-01 00:00:00.0 text/html http://humrep.oxfordjournals.org/cgi/content/short/17/3/555 https://doi.org/10.1093/humrep/17.3.555 en eng Oxford University Press http://humrep.oxfordjournals.org/cgi/content/short/17/3/555 http://dx.doi.org/10.1093/humrep/17.3.555 Copyright (C) 2002, European Society of Human Reproduction and Embryology Reproductive genetics TEXT 2002 fthighwire https://doi.org/10.1093/humrep/17.3.555 2013-05-28T04:34:27Z BACKGROUND: Endometriosis is known to cluster within nuclear families. The extent of familial clustering can be evaluated in Iceland with its large population-based genealogical database. METHODS AND RESULTS: Applying several measures of familiality we demonstrated that 750 women with endometriosis were significantly more interrelated than matched control groups. The risk ratio for sisters was 5.20 ( P < 0.001) and for cousins 1.56 ( P = 0.003). The average kinship coefficient for the patients was significantly higher than that calculated for 1000 sets of 750 matched controls ( P < 0.001) and this remained significant when contribution from first-degree relatives was excluded ( P < 0.05). The minimum number of ancestors required to account for the group of patients was compared with the minimum number of ancestors required to account for the control groups at different time points in the past. The minimum number of founders for the group of patients was significantly smaller than for the control groups. Affected cousin pairs were as likely to be paternally connected as maternally connected. CONCLUSIONS: This is the first population-based study using an extensive genealogy database to examine the genetic contribution to endometriosis. A genetic factor is present, with a raised risk in close and more distant relatives, and a definite kinship factor with maternal and paternal inheritance contributing. Text Iceland HighWire Press (Stanford University) Human Reproduction 17 3 555 559 |
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HighWire Press (Stanford University) |
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fthighwire |
language |
English |
topic |
Reproductive genetics |
spellingShingle |
Reproductive genetics Stefansson, H. Geirsson, R.T. Steinthorsdottir, V. Jonsson, H. Manolescu, A. Kong, A. Ingadottir, G. Gulcher, J. Stefansson, K. Genetic factors contribute to the risk of developing endometriosis |
topic_facet |
Reproductive genetics |
description |
BACKGROUND: Endometriosis is known to cluster within nuclear families. The extent of familial clustering can be evaluated in Iceland with its large population-based genealogical database. METHODS AND RESULTS: Applying several measures of familiality we demonstrated that 750 women with endometriosis were significantly more interrelated than matched control groups. The risk ratio for sisters was 5.20 ( P < 0.001) and for cousins 1.56 ( P = 0.003). The average kinship coefficient for the patients was significantly higher than that calculated for 1000 sets of 750 matched controls ( P < 0.001) and this remained significant when contribution from first-degree relatives was excluded ( P < 0.05). The minimum number of ancestors required to account for the group of patients was compared with the minimum number of ancestors required to account for the control groups at different time points in the past. The minimum number of founders for the group of patients was significantly smaller than for the control groups. Affected cousin pairs were as likely to be paternally connected as maternally connected. CONCLUSIONS: This is the first population-based study using an extensive genealogy database to examine the genetic contribution to endometriosis. A genetic factor is present, with a raised risk in close and more distant relatives, and a definite kinship factor with maternal and paternal inheritance contributing. |
format |
Text |
author |
Stefansson, H. Geirsson, R.T. Steinthorsdottir, V. Jonsson, H. Manolescu, A. Kong, A. Ingadottir, G. Gulcher, J. Stefansson, K. |
author_facet |
Stefansson, H. Geirsson, R.T. Steinthorsdottir, V. Jonsson, H. Manolescu, A. Kong, A. Ingadottir, G. Gulcher, J. Stefansson, K. |
author_sort |
Stefansson, H. |
title |
Genetic factors contribute to the risk of developing endometriosis |
title_short |
Genetic factors contribute to the risk of developing endometriosis |
title_full |
Genetic factors contribute to the risk of developing endometriosis |
title_fullStr |
Genetic factors contribute to the risk of developing endometriosis |
title_full_unstemmed |
Genetic factors contribute to the risk of developing endometriosis |
title_sort |
genetic factors contribute to the risk of developing endometriosis |
publisher |
Oxford University Press |
publishDate |
2002 |
url |
http://humrep.oxfordjournals.org/cgi/content/short/17/3/555 https://doi.org/10.1093/humrep/17.3.555 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://humrep.oxfordjournals.org/cgi/content/short/17/3/555 http://dx.doi.org/10.1093/humrep/17.3.555 |
op_rights |
Copyright (C) 2002, European Society of Human Reproduction and Embryology |
op_doi |
https://doi.org/10.1093/humrep/17.3.555 |
container_title |
Human Reproduction |
container_volume |
17 |
container_issue |
3 |
container_start_page |
555 |
op_container_end_page |
559 |
_version_ |
1766040731973058560 |