Sequence variants at CYP1A1-CYP1A2 and AHR associate with coffee consumption
Coffee is the most commonly used stimulant and caffeine is its main psychoactive ingredient. The heritability of coffee consumption has been estimated at around 50%. We performed a meta-analysis of four genome-wide association studies of coffee consumption among coffee drinkers from Iceland ( n = 26...
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fthighwire:oai:open-archive.highwire.org:hmg:ddr086v1 2023-05-15T16:47:58+02:00 Sequence variants at CYP1A1-CYP1A2 and AHR associate with coffee consumption Sulem, Patrick Gudbjartsson, Daniel F. Geller, Frank Prokopenko, Inga Feenstra, Bjarke Aben, Katja K.H. Franke, Barbara den Heijer, Martin Kovacs, Peter Stumvoll, Michael Mägi, Reedik Yanek, Lisa R. Becker, Lewis C. Boyd, Heather A. Stacey, Simon N. Walters, G. Bragi Jonsdottir, Adalbjorg Thorleifsson, Gudmar Holm, Hilma Gudjonsson, Sigurjon A. Rafnar, Thorunn Björnsdottir, Gyda Becker, Diane M. Melbye, Mads Kong, Augustine Tönjes, Anke Thorgeirsson, Thorgeir Thorsteinsdottir, Unnur Kiemeney, Lambertus A. Stefansson, Kari 2011-02-28 07:02:29.0 text/html http://hmg.oxfordjournals.org/cgi/content/short/ddr086v1 https://doi.org/10.1093/hmg/ddr086 en eng Oxford University Press http://hmg.oxfordjournals.org/cgi/content/short/ddr086v1 http://dx.doi.org/10.1093/hmg/ddr086 Copyright (C) 2011, Oxford University Press Article TEXT 2011 fthighwire https://doi.org/10.1093/hmg/ddr086 2013-05-27T21:38:01Z Coffee is the most commonly used stimulant and caffeine is its main psychoactive ingredient. The heritability of coffee consumption has been estimated at around 50%. We performed a meta-analysis of four genome-wide association studies of coffee consumption among coffee drinkers from Iceland ( n = 2680), the Netherlands ( n = 2791), the Sorbs Slavonic population isolate in Germany ( n = 771) and the USA ( n = 369) using both directly genotyped and imputed single nucleotide polymorphisms (SNPs) (2.5 million SNPs). SNPs at the two most significant loci were also genotyped in a sample set from Iceland ( n = 2430) and a Danish sample set consisting of pregnant women ( n = 1620). Combining all data, two sequence variants significantly associated with increased coffee consumption: rs2472297-T located between CYP1A1 and CYP1A2 at 15q24 ( P = 5.4 · 10−14) and rs6968865-T near aryl hydrocarbon receptor ( AHR ) at 7p21 ( P = 2.3 · 10−11). An effect of ∼0.2 cups a day per allele was observed for both SNPs. CYP1A2 is the main caffeine metabolizing enzyme and is also involved in drug metabolism. AHR detects xenobiotics, such as polycyclic aryl hydrocarbons found in roasted coffee, and induces transcription of CYP1A1 and CYP1A2 . The association of these SNPs with coffee consumption was present in both smokers and non-smokers. Text Iceland HighWire Press (Stanford University) Human Molecular Genetics 20 10 2071 2077 |
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English |
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Article Sulem, Patrick Gudbjartsson, Daniel F. Geller, Frank Prokopenko, Inga Feenstra, Bjarke Aben, Katja K.H. Franke, Barbara den Heijer, Martin Kovacs, Peter Stumvoll, Michael Mägi, Reedik Yanek, Lisa R. Becker, Lewis C. Boyd, Heather A. Stacey, Simon N. Walters, G. Bragi Jonsdottir, Adalbjorg Thorleifsson, Gudmar Holm, Hilma Gudjonsson, Sigurjon A. Rafnar, Thorunn Björnsdottir, Gyda Becker, Diane M. Melbye, Mads Kong, Augustine Tönjes, Anke Thorgeirsson, Thorgeir Thorsteinsdottir, Unnur Kiemeney, Lambertus A. Stefansson, Kari Sequence variants at CYP1A1-CYP1A2 and AHR associate with coffee consumption |
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description |
Coffee is the most commonly used stimulant and caffeine is its main psychoactive ingredient. The heritability of coffee consumption has been estimated at around 50%. We performed a meta-analysis of four genome-wide association studies of coffee consumption among coffee drinkers from Iceland ( n = 2680), the Netherlands ( n = 2791), the Sorbs Slavonic population isolate in Germany ( n = 771) and the USA ( n = 369) using both directly genotyped and imputed single nucleotide polymorphisms (SNPs) (2.5 million SNPs). SNPs at the two most significant loci were also genotyped in a sample set from Iceland ( n = 2430) and a Danish sample set consisting of pregnant women ( n = 1620). Combining all data, two sequence variants significantly associated with increased coffee consumption: rs2472297-T located between CYP1A1 and CYP1A2 at 15q24 ( P = 5.4 · 10−14) and rs6968865-T near aryl hydrocarbon receptor ( AHR ) at 7p21 ( P = 2.3 · 10−11). An effect of ∼0.2 cups a day per allele was observed for both SNPs. CYP1A2 is the main caffeine metabolizing enzyme and is also involved in drug metabolism. AHR detects xenobiotics, such as polycyclic aryl hydrocarbons found in roasted coffee, and induces transcription of CYP1A1 and CYP1A2 . The association of these SNPs with coffee consumption was present in both smokers and non-smokers. |
format |
Text |
author |
Sulem, Patrick Gudbjartsson, Daniel F. Geller, Frank Prokopenko, Inga Feenstra, Bjarke Aben, Katja K.H. Franke, Barbara den Heijer, Martin Kovacs, Peter Stumvoll, Michael Mägi, Reedik Yanek, Lisa R. Becker, Lewis C. Boyd, Heather A. Stacey, Simon N. Walters, G. Bragi Jonsdottir, Adalbjorg Thorleifsson, Gudmar Holm, Hilma Gudjonsson, Sigurjon A. Rafnar, Thorunn Björnsdottir, Gyda Becker, Diane M. Melbye, Mads Kong, Augustine Tönjes, Anke Thorgeirsson, Thorgeir Thorsteinsdottir, Unnur Kiemeney, Lambertus A. Stefansson, Kari |
author_facet |
Sulem, Patrick Gudbjartsson, Daniel F. Geller, Frank Prokopenko, Inga Feenstra, Bjarke Aben, Katja K.H. Franke, Barbara den Heijer, Martin Kovacs, Peter Stumvoll, Michael Mägi, Reedik Yanek, Lisa R. Becker, Lewis C. Boyd, Heather A. Stacey, Simon N. Walters, G. Bragi Jonsdottir, Adalbjorg Thorleifsson, Gudmar Holm, Hilma Gudjonsson, Sigurjon A. Rafnar, Thorunn Björnsdottir, Gyda Becker, Diane M. Melbye, Mads Kong, Augustine Tönjes, Anke Thorgeirsson, Thorgeir Thorsteinsdottir, Unnur Kiemeney, Lambertus A. Stefansson, Kari |
author_sort |
Sulem, Patrick |
title |
Sequence variants at CYP1A1-CYP1A2 and AHR associate with coffee consumption |
title_short |
Sequence variants at CYP1A1-CYP1A2 and AHR associate with coffee consumption |
title_full |
Sequence variants at CYP1A1-CYP1A2 and AHR associate with coffee consumption |
title_fullStr |
Sequence variants at CYP1A1-CYP1A2 and AHR associate with coffee consumption |
title_full_unstemmed |
Sequence variants at CYP1A1-CYP1A2 and AHR associate with coffee consumption |
title_sort |
sequence variants at cyp1a1-cyp1a2 and ahr associate with coffee consumption |
publisher |
Oxford University Press |
publishDate |
2011 |
url |
http://hmg.oxfordjournals.org/cgi/content/short/ddr086v1 https://doi.org/10.1093/hmg/ddr086 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://hmg.oxfordjournals.org/cgi/content/short/ddr086v1 http://dx.doi.org/10.1093/hmg/ddr086 |
op_rights |
Copyright (C) 2011, Oxford University Press |
op_doi |
https://doi.org/10.1093/hmg/ddr086 |
container_title |
Human Molecular Genetics |
container_volume |
20 |
container_issue |
10 |
container_start_page |
2071 |
op_container_end_page |
2077 |
_version_ |
1766038070201679872 |