Analysis of CAG Repeat of the Machado-Joseph Gene in Human, Chimpanzee and Monkey Populations: A Variant Nucleotide is Associated with the Number of CAG Repeats

• Published in: Human Molecular Genetics
• Main Authors: Limprasert, Pornprot, Nouri, Nassim, Heyman, Rock A., Nopparatana, Chamnong, Kamonsilp, Mahatana, Deininger, Prescott L., Keats, Bronya J. B.
• Format: Text
• Language: English
• Published: Oxford University Press 1996
• Subjects: Articles; Greenland; Triplets; inuit
• Online Access: http://hmg.oxfordjournals.org/cgi/content/short/5/2/207; https://doi.org/10.1093/hmg/5.2.207

Machado-Joseph disease (MJD) is an autosomal dominant neurodegenerative disorder associated with an unstable and expanded CAG repeat. We analyzed this locus from various sources including MJD families, Acadian, African American, Caucasian, Greenland Inuit and Thai populations. The range of the CAG r...