European genome-wide association study identifies SLC14A1 as a new urinary bladder cancer susceptibility gene
Three genome-wide association studies in Europe and the USA have reported eight urinary bladder cancer (UBC) susceptibility loci. Using extended case and control series and 1000 Genomes imputations of 5 340 737 single-nucleotide polymorphisms (SNPs), we searched for additional loci in the European G...
Published in: | Human Molecular Genetics |
---|---|
Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Format: | Text |
Language: | English |
Published: |
Oxford University Press
2011
|
Subjects: | |
Online Access: | http://hmg.oxfordjournals.org/cgi/content/short/20/21/4268 https://doi.org/10.1093/hmg/ddr303 |
id |
fthighwire:oai:open-archive.highwire.org:hmg:20/21/4268 |
---|---|
record_format |
openpolar |
spelling |
fthighwire:oai:open-archive.highwire.org:hmg:20/21/4268 2023-05-15T16:50:57+02:00 European genome-wide association study identifies SLC14A1 as a new urinary bladder cancer susceptibility gene Rafnar, Thorunn Vermeulen, Sita H. Sulem, Patrick Thorleifsson, Gudmar Aben, Katja K. Witjes, J. Alfred Grotenhuis, Anne J. Verhaegh, Gerald W. Hulsbergen-van de Kaa, Christina A. Besenbacher, Soren Gudbjartsson, Daniel Stacey, Simon N. Gudmundsson, Julius Johannsdottir, Hrefna Bjarnason, Hjordis Zanon, Carlo Helgadottir, Hafdis Jonasson, Jon Gunnlaugur Tryggvadottir, Laufey Jonsson, Eirikur Geirsson, Gudmundur Nikulasson, Sigfus Petursdottir, Vigdis Bishop, D. Timothy Chung-Sak, Sei Choudhury, Ananya Elliott, Faye Barrett, Jennifer H. Knowles, Margaret A. de Verdier, Petra J. Ryk, Charlotta Lindblom, Annika Rudnai, Peter Gurzau, Eugene Koppova, Kvetoslava Vineis, Paolo Polidoro, Silvia Guarrera, Simonetta Sacerdote, Carlotta Panadero, Angeles Sanz-Velez, José I. Sanchez, Manuel Valdivia, Gabriel Garcia-Prats, Maria D. Hengstler, Jan G. Selinski, Silvia Gerullis, Holger Ovsiannikov, Daniel Khezri, Abdolaziz Aminsharifi, Alireza 2011-11-01 00:00:00.0 text/html http://hmg.oxfordjournals.org/cgi/content/short/20/21/4268 https://doi.org/10.1093/hmg/ddr303 en eng Oxford University Press http://hmg.oxfordjournals.org/cgi/content/short/20/21/4268 http://dx.doi.org/10.1093/hmg/ddr303 Copyright (C) 2011, Oxford University Press ASSOCIATION STUDIES ARTICLES TEXT 2011 fthighwire https://doi.org/10.1093/hmg/ddr303 2011-10-12T12:37:03Z Three genome-wide association studies in Europe and the USA have reported eight urinary bladder cancer (UBC) susceptibility loci. Using extended case and control series and 1000 Genomes imputations of 5 340 737 single-nucleotide polymorphisms (SNPs), we searched for additional loci in the European GWAS. The discovery sample set consisted of 1631 cases and 3822 controls from the Netherlands and 603 cases and 37 781 controls from Iceland. For follow-up, we used 3790 cases and 7507 controls from 13 sample sets of European and Iranian ancestry. Based on the discovery analysis, we followed up signals in the urea transporter (UT) gene SLC14A . The strongest signal at this locus was represented by a SNP in intron 3, rs17674580, that reached genome-wide significance in the overall analysis of the discovery and follow-up groups: odds ratio = 1.17, P = 7.6 × 10−11. SLC14A1 codes for UTs that define the Kidd blood group and are crucial for the maintenance of a constant urea concentration gradient in the renal medulla and, through this, the kidney's ability to concentrate urine. It is speculated that rs17674580, or other sequence variants in LD with it, indirectly modifies UBC risk by affecting urine production. If confirmed, this would support the ‘urogenous contact hypothesis’ that urine production and voiding frequency modify the risk of UBC. Text Iceland HighWire Press (Stanford University) Kidd ENVELOPE(-65.972,-65.972,-66.448,-66.448) Human Molecular Genetics 20 21 4268 4281 |
institution |
Open Polar |
collection |
HighWire Press (Stanford University) |
op_collection_id |
fthighwire |
language |
English |
topic |
ASSOCIATION STUDIES ARTICLES |
spellingShingle |
ASSOCIATION STUDIES ARTICLES Rafnar, Thorunn Vermeulen, Sita H. Sulem, Patrick Thorleifsson, Gudmar Aben, Katja K. Witjes, J. Alfred Grotenhuis, Anne J. Verhaegh, Gerald W. Hulsbergen-van de Kaa, Christina A. Besenbacher, Soren Gudbjartsson, Daniel Stacey, Simon N. Gudmundsson, Julius Johannsdottir, Hrefna Bjarnason, Hjordis Zanon, Carlo Helgadottir, Hafdis Jonasson, Jon Gunnlaugur Tryggvadottir, Laufey Jonsson, Eirikur Geirsson, Gudmundur Nikulasson, Sigfus Petursdottir, Vigdis Bishop, D. Timothy Chung-Sak, Sei Choudhury, Ananya Elliott, Faye Barrett, Jennifer H. Knowles, Margaret A. de Verdier, Petra J. Ryk, Charlotta Lindblom, Annika Rudnai, Peter Gurzau, Eugene Koppova, Kvetoslava Vineis, Paolo Polidoro, Silvia Guarrera, Simonetta Sacerdote, Carlotta Panadero, Angeles Sanz-Velez, José I. Sanchez, Manuel Valdivia, Gabriel Garcia-Prats, Maria D. Hengstler, Jan G. Selinski, Silvia Gerullis, Holger Ovsiannikov, Daniel Khezri, Abdolaziz Aminsharifi, Alireza European genome-wide association study identifies SLC14A1 as a new urinary bladder cancer susceptibility gene |
topic_facet |
ASSOCIATION STUDIES ARTICLES |
description |
Three genome-wide association studies in Europe and the USA have reported eight urinary bladder cancer (UBC) susceptibility loci. Using extended case and control series and 1000 Genomes imputations of 5 340 737 single-nucleotide polymorphisms (SNPs), we searched for additional loci in the European GWAS. The discovery sample set consisted of 1631 cases and 3822 controls from the Netherlands and 603 cases and 37 781 controls from Iceland. For follow-up, we used 3790 cases and 7507 controls from 13 sample sets of European and Iranian ancestry. Based on the discovery analysis, we followed up signals in the urea transporter (UT) gene SLC14A . The strongest signal at this locus was represented by a SNP in intron 3, rs17674580, that reached genome-wide significance in the overall analysis of the discovery and follow-up groups: odds ratio = 1.17, P = 7.6 × 10−11. SLC14A1 codes for UTs that define the Kidd blood group and are crucial for the maintenance of a constant urea concentration gradient in the renal medulla and, through this, the kidney's ability to concentrate urine. It is speculated that rs17674580, or other sequence variants in LD with it, indirectly modifies UBC risk by affecting urine production. If confirmed, this would support the ‘urogenous contact hypothesis’ that urine production and voiding frequency modify the risk of UBC. |
format |
Text |
author |
Rafnar, Thorunn Vermeulen, Sita H. Sulem, Patrick Thorleifsson, Gudmar Aben, Katja K. Witjes, J. Alfred Grotenhuis, Anne J. Verhaegh, Gerald W. Hulsbergen-van de Kaa, Christina A. Besenbacher, Soren Gudbjartsson, Daniel Stacey, Simon N. Gudmundsson, Julius Johannsdottir, Hrefna Bjarnason, Hjordis Zanon, Carlo Helgadottir, Hafdis Jonasson, Jon Gunnlaugur Tryggvadottir, Laufey Jonsson, Eirikur Geirsson, Gudmundur Nikulasson, Sigfus Petursdottir, Vigdis Bishop, D. Timothy Chung-Sak, Sei Choudhury, Ananya Elliott, Faye Barrett, Jennifer H. Knowles, Margaret A. de Verdier, Petra J. Ryk, Charlotta Lindblom, Annika Rudnai, Peter Gurzau, Eugene Koppova, Kvetoslava Vineis, Paolo Polidoro, Silvia Guarrera, Simonetta Sacerdote, Carlotta Panadero, Angeles Sanz-Velez, José I. Sanchez, Manuel Valdivia, Gabriel Garcia-Prats, Maria D. Hengstler, Jan G. Selinski, Silvia Gerullis, Holger Ovsiannikov, Daniel Khezri, Abdolaziz Aminsharifi, Alireza |
author_facet |
Rafnar, Thorunn Vermeulen, Sita H. Sulem, Patrick Thorleifsson, Gudmar Aben, Katja K. Witjes, J. Alfred Grotenhuis, Anne J. Verhaegh, Gerald W. Hulsbergen-van de Kaa, Christina A. Besenbacher, Soren Gudbjartsson, Daniel Stacey, Simon N. Gudmundsson, Julius Johannsdottir, Hrefna Bjarnason, Hjordis Zanon, Carlo Helgadottir, Hafdis Jonasson, Jon Gunnlaugur Tryggvadottir, Laufey Jonsson, Eirikur Geirsson, Gudmundur Nikulasson, Sigfus Petursdottir, Vigdis Bishop, D. Timothy Chung-Sak, Sei Choudhury, Ananya Elliott, Faye Barrett, Jennifer H. Knowles, Margaret A. de Verdier, Petra J. Ryk, Charlotta Lindblom, Annika Rudnai, Peter Gurzau, Eugene Koppova, Kvetoslava Vineis, Paolo Polidoro, Silvia Guarrera, Simonetta Sacerdote, Carlotta Panadero, Angeles Sanz-Velez, José I. Sanchez, Manuel Valdivia, Gabriel Garcia-Prats, Maria D. Hengstler, Jan G. Selinski, Silvia Gerullis, Holger Ovsiannikov, Daniel Khezri, Abdolaziz Aminsharifi, Alireza |
author_sort |
Rafnar, Thorunn |
title |
European genome-wide association study identifies SLC14A1 as a new urinary bladder cancer susceptibility gene |
title_short |
European genome-wide association study identifies SLC14A1 as a new urinary bladder cancer susceptibility gene |
title_full |
European genome-wide association study identifies SLC14A1 as a new urinary bladder cancer susceptibility gene |
title_fullStr |
European genome-wide association study identifies SLC14A1 as a new urinary bladder cancer susceptibility gene |
title_full_unstemmed |
European genome-wide association study identifies SLC14A1 as a new urinary bladder cancer susceptibility gene |
title_sort |
european genome-wide association study identifies slc14a1 as a new urinary bladder cancer susceptibility gene |
publisher |
Oxford University Press |
publishDate |
2011 |
url |
http://hmg.oxfordjournals.org/cgi/content/short/20/21/4268 https://doi.org/10.1093/hmg/ddr303 |
long_lat |
ENVELOPE(-65.972,-65.972,-66.448,-66.448) |
geographic |
Kidd |
geographic_facet |
Kidd |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://hmg.oxfordjournals.org/cgi/content/short/20/21/4268 http://dx.doi.org/10.1093/hmg/ddr303 |
op_rights |
Copyright (C) 2011, Oxford University Press |
op_doi |
https://doi.org/10.1093/hmg/ddr303 |
container_title |
Human Molecular Genetics |
container_volume |
20 |
container_issue |
21 |
container_start_page |
4268 |
op_container_end_page |
4281 |
_version_ |
1766041056340606976 |