Long term follow up of patients with anterior myocardial infarction complicated by left ventricular thrombus in the thrombolytic era.
OBJECTIVES: To examine the appearance and resolution of left ventricular thrombi and to study the relation between thrombus and mortality during long term follow up after anterior myocardial infarction. DESIGN: Ninety nine consecutive patients were prospectively studied until the last included patie...
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1996
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fthighwire:oai:open-archive.highwire.org:heartjnl:75/3/252 2023-05-15T17:45:01+02:00 Long term follow up of patients with anterior myocardial infarction complicated by left ventricular thrombus in the thrombolytic era. Mooe, T. Teien, D. Karp, K. Eriksson, P. 1996-03-01 00:00:00.0 text/html http://heart.bmj.com/cgi/content/short/75/3/252 https://doi.org/10.1136/hrt.75.3.252 en eng BMJ Publishing Group Ltd http://heart.bmj.com/cgi/content/short/75/3/252 http://dx.doi.org/10.1136/hrt.75.3.252 Copyright (C) 1996, BMJ Publishing Group Ltd Research Article TEXT 1996 fthighwire https://doi.org/10.1136/hrt.75.3.252 2013-05-27T04:37:36Z OBJECTIVES: To examine the appearance and resolution of left ventricular thrombi and to study the relation between thrombus and mortality during long term follow up after anterior myocardial infarction. DESIGN: Ninety nine consecutive patients were prospectively studied until the last included patient had been followed for one year. Streptokinase and aspirin were used routinely, anticoagulants only after a decision by the attending physician. Echocardiography was performed within 3 d of admission, before discharge, and after one, three, and 12 months. SETTING: Umeå University Hospital, a teaching hospital in Northern Sweden. MAIN OUTCOME MEASURES: Left ventricular thrombus, segmental myocardial function, and mortality during follow up. RESULTS: Thirty patients (30%) had a thrombus on discharge. One month, three months, and 12 months after hospital discharge, the thrombus had resolved in 81%, 84%, and 90% of the patients, respectively. The proportion of resolved thrombi at one month was high irrespective of whether anticoagulants were given (10/11, 91%) or not (12/16, 75%), P = 0.4. New thrombi appeared in 12 patients after discharge and resolution and reapperance of thrombi continued during the follow up period. Patients who developed a thrombus during the hospital stay (n = 44, 44%) had more extensive myocardial dysfunction on discharge (P < 0.001) and significantly higher mortality during the follow up period than those without a thrombus (23% v 7%, P < 0.01). CONCLUSIONS: With routine thrombolytic and aspirin treatment of anterior myocardial infarction, left ventricular thrombi usually resolve during the first month after hospital discharge. Appearance and resolution of thrombi continue, however, in a significant proportion of the patients during long term follow up. A left ventricular thrombus during the initial hospital stay is associated with high long term mortality. Text Northern Sweden HighWire Press (Stanford University) Heart 75 3 252 256 |
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Research Article Mooe, T. Teien, D. Karp, K. Eriksson, P. Long term follow up of patients with anterior myocardial infarction complicated by left ventricular thrombus in the thrombolytic era. |
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Research Article |
description |
OBJECTIVES: To examine the appearance and resolution of left ventricular thrombi and to study the relation between thrombus and mortality during long term follow up after anterior myocardial infarction. DESIGN: Ninety nine consecutive patients were prospectively studied until the last included patient had been followed for one year. Streptokinase and aspirin were used routinely, anticoagulants only after a decision by the attending physician. Echocardiography was performed within 3 d of admission, before discharge, and after one, three, and 12 months. SETTING: Umeå University Hospital, a teaching hospital in Northern Sweden. MAIN OUTCOME MEASURES: Left ventricular thrombus, segmental myocardial function, and mortality during follow up. RESULTS: Thirty patients (30%) had a thrombus on discharge. One month, three months, and 12 months after hospital discharge, the thrombus had resolved in 81%, 84%, and 90% of the patients, respectively. The proportion of resolved thrombi at one month was high irrespective of whether anticoagulants were given (10/11, 91%) or not (12/16, 75%), P = 0.4. New thrombi appeared in 12 patients after discharge and resolution and reapperance of thrombi continued during the follow up period. Patients who developed a thrombus during the hospital stay (n = 44, 44%) had more extensive myocardial dysfunction on discharge (P < 0.001) and significantly higher mortality during the follow up period than those without a thrombus (23% v 7%, P < 0.01). CONCLUSIONS: With routine thrombolytic and aspirin treatment of anterior myocardial infarction, left ventricular thrombi usually resolve during the first month after hospital discharge. Appearance and resolution of thrombi continue, however, in a significant proportion of the patients during long term follow up. A left ventricular thrombus during the initial hospital stay is associated with high long term mortality. |
format |
Text |
author |
Mooe, T. Teien, D. Karp, K. Eriksson, P. |
author_facet |
Mooe, T. Teien, D. Karp, K. Eriksson, P. |
author_sort |
Mooe, T. |
title |
Long term follow up of patients with anterior myocardial infarction complicated by left ventricular thrombus in the thrombolytic era. |
title_short |
Long term follow up of patients with anterior myocardial infarction complicated by left ventricular thrombus in the thrombolytic era. |
title_full |
Long term follow up of patients with anterior myocardial infarction complicated by left ventricular thrombus in the thrombolytic era. |
title_fullStr |
Long term follow up of patients with anterior myocardial infarction complicated by left ventricular thrombus in the thrombolytic era. |
title_full_unstemmed |
Long term follow up of patients with anterior myocardial infarction complicated by left ventricular thrombus in the thrombolytic era. |
title_sort |
long term follow up of patients with anterior myocardial infarction complicated by left ventricular thrombus in the thrombolytic era. |
publisher |
BMJ Publishing Group Ltd |
publishDate |
1996 |
url |
http://heart.bmj.com/cgi/content/short/75/3/252 https://doi.org/10.1136/hrt.75.3.252 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_relation |
http://heart.bmj.com/cgi/content/short/75/3/252 http://dx.doi.org/10.1136/hrt.75.3.252 |
op_rights |
Copyright (C) 1996, BMJ Publishing Group Ltd |
op_doi |
https://doi.org/10.1136/hrt.75.3.252 |
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Heart |
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75 |
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3 |
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252 |
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256 |
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1766147740609282048 |