Familial aggregation of coronary heart disease in a high incidence area (North Karelia, Finland).

Occurrence of coronary heart disease was assessed in families of 211 men under the age of 56 from East Finland. Fifty men were survivors of recent myocardial infarctions, 55 had died of myocardial infarction, 53 suffered from uncomplicated angina pectoris, and 53 were healthy reference men. Overall...

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Published in:Heart
Main Author: Rissanen, A M
Format: Text
Language:English
Published: British Medical Journal Publishing Group 1979
Subjects:
Online Access:http://heart.bmj.com/cgi/content/short/42/3/294
https://doi.org/10.1136/hrt.42.3.294
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spelling fthighwire:oai:open-archive.highwire.org:heartjnl:42/3/294 2023-05-15T17:00:08+02:00 Familial aggregation of coronary heart disease in a high incidence area (North Karelia, Finland). Rissanen, A M 1979-09-01 00:00:00.0 text/html http://heart.bmj.com/cgi/content/short/42/3/294 https://doi.org/10.1136/hrt.42.3.294 en eng British Medical Journal Publishing Group http://heart.bmj.com/cgi/content/short/42/3/294 http://dx.doi.org/10.1136/hrt.42.3.294 Copyright (C) 1979, BMJ Publishing Group Ltd Research Article TEXT 1979 fthighwire https://doi.org/10.1136/hrt.42.3.294 2012-06-19T01:58:11Z Occurrence of coronary heart disease was assessed in families of 211 men under the age of 56 from East Finland. Fifty men were survivors of recent myocardial infarctions, 55 had died of myocardial infarction, 53 suffered from uncomplicated angina pectoris, and 53 were healthy reference men. Overall prevalence of coronary heart disease was similar in familes of all case probands. By age 70, case fathers had a 6 times greater cumulative risk (a 36% chance) of dying from coronary heart disease than reference fathers, whereas there was only a small difference between case and reference mothers. Cumulative risk of developing fatal or non-fatal coronary heart disease by age 65 was 4.5-fold for case brothers (70%) and 2.6-fold for case sisters (40%), when compared with reference sibs. The risk was greatest for case sibs with a parental, especially a maternal, history of premature coronary heart disease. Clinical manifestations of coronary heart disease showed similarities within sibships. Cardiac deaths were commonest in sibs of the fatal myocardial infarction probands, whereas angina was commonest in sibs of the angina pectoris probands. Text karelia* HighWire Press (Stanford University) Heart 42 3 294 303
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collection HighWire Press (Stanford University)
op_collection_id fthighwire
language English
topic Research Article
spellingShingle Research Article
Rissanen, A M
Familial aggregation of coronary heart disease in a high incidence area (North Karelia, Finland).
topic_facet Research Article
description Occurrence of coronary heart disease was assessed in families of 211 men under the age of 56 from East Finland. Fifty men were survivors of recent myocardial infarctions, 55 had died of myocardial infarction, 53 suffered from uncomplicated angina pectoris, and 53 were healthy reference men. Overall prevalence of coronary heart disease was similar in familes of all case probands. By age 70, case fathers had a 6 times greater cumulative risk (a 36% chance) of dying from coronary heart disease than reference fathers, whereas there was only a small difference between case and reference mothers. Cumulative risk of developing fatal or non-fatal coronary heart disease by age 65 was 4.5-fold for case brothers (70%) and 2.6-fold for case sisters (40%), when compared with reference sibs. The risk was greatest for case sibs with a parental, especially a maternal, history of premature coronary heart disease. Clinical manifestations of coronary heart disease showed similarities within sibships. Cardiac deaths were commonest in sibs of the fatal myocardial infarction probands, whereas angina was commonest in sibs of the angina pectoris probands.
format Text
author Rissanen, A M
author_facet Rissanen, A M
author_sort Rissanen, A M
title Familial aggregation of coronary heart disease in a high incidence area (North Karelia, Finland).
title_short Familial aggregation of coronary heart disease in a high incidence area (North Karelia, Finland).
title_full Familial aggregation of coronary heart disease in a high incidence area (North Karelia, Finland).
title_fullStr Familial aggregation of coronary heart disease in a high incidence area (North Karelia, Finland).
title_full_unstemmed Familial aggregation of coronary heart disease in a high incidence area (North Karelia, Finland).
title_sort familial aggregation of coronary heart disease in a high incidence area (north karelia, finland).
publisher British Medical Journal Publishing Group
publishDate 1979
url http://heart.bmj.com/cgi/content/short/42/3/294
https://doi.org/10.1136/hrt.42.3.294
genre karelia*
genre_facet karelia*
op_relation http://heart.bmj.com/cgi/content/short/42/3/294
http://dx.doi.org/10.1136/hrt.42.3.294
op_rights Copyright (C) 1979, BMJ Publishing Group Ltd
op_doi https://doi.org/10.1136/hrt.42.3.294
container_title Heart
container_volume 42
container_issue 3
container_start_page 294
op_container_end_page 303
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