Low folate levels may protect against colorectal cancer
Background and aims: Dietary folate is believed to protect against colorectal cancer (CRC). However, few studies have addressed the role of circulating levels of folate. The aim of this study was to relate prediagnostic plasma folate and homocysteine concentrations and the methylenetetrahydrofolate...
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fthighwire:oai:open-archive.highwire.org:gutjnl:gut.2005.085480v2 2023-05-15T17:44:53+02:00 Low folate levels may protect against colorectal cancer Van Guelpen, Bethany Hultdin, Johan Johansson, Ingegerd Hallmans, Göran Stenling, Roger Riboli, Elio Winkvist, Anna Palmqvist, Richard 2006-04-26 04:56:33.0 text/html http://gut.bmj.com/cgi/content/short/gut.2005.085480v2 https://doi.org/10.1136/gut.2005.085480 en eng BMJ Publishing Group Ltd http://gut.bmj.com/cgi/content/short/gut.2005.085480v2 http://dx.doi.org/10.1136/gut.2005.085480 Copyright (C) 2006, BMJ Publishing Group Paper TEXT 2006 fthighwire https://doi.org/10.1136/gut.2005.085480 2013-05-27T15:36:12Z Background and aims: Dietary folate is believed to protect against colorectal cancer (CRC). However, few studies have addressed the role of circulating levels of folate. The aim of this study was to relate prediagnostic plasma folate and homocysteine concentrations and the methylenetetrahydrofolate reductase (MTHFR) 677C>T and 1298A>C polymorphisms to the risk of developing CRC. Subjects: Subjects were 226 cases and 437 matched referents from the population-based Northern Sweden Health and Disease Cohort. Results: We observed a bell-shaped association between plasma folate concentrations and CRC risk; multivariate odds ratio for middle versus lowest quintile 2.00 (95% CI 1.13-3.56). In subjects with follow-up times greater than the median of 4.2 years, however, plasma folate concentrations were strongly, positively related to CRC risk; multivariate odds ratio for highest versus lowest quintile 3.87 (95% CI 1.52-9.87, P-trend=0.007). Homocysteine was not associated with CRC risk. Multivariate odds ratios for the MTHFR polymorphisms were, for 677 TT versus CC, 0.41 (95% CI 0.19-0.85, P- trend=0.062) and, for 1298 CC versus AA, 1.62 (95% CI 0.94-2.81, P-trend=0.028). Interaction analysis suggested that the result for 1298A>C may have been largely due to linkage disequilibrium with 677C>T. The reduced CRC risk in 677 TT-homozygotes was independent of plasma folate status. Conclusions: Our findings suggest a decreased CRC risk in subjects with low folate status. This possibility of a detrimental component to the role of folate in carcinogenesis could have implications in the ongoing debate in Europe concerning mandatory folate fortification of foods. Text Northern Sweden HighWire Press (Stanford University) Gut 55 10 1461 1466 |
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HighWire Press (Stanford University) |
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Paper |
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Paper Van Guelpen, Bethany Hultdin, Johan Johansson, Ingegerd Hallmans, Göran Stenling, Roger Riboli, Elio Winkvist, Anna Palmqvist, Richard Low folate levels may protect against colorectal cancer |
topic_facet |
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description |
Background and aims: Dietary folate is believed to protect against colorectal cancer (CRC). However, few studies have addressed the role of circulating levels of folate. The aim of this study was to relate prediagnostic plasma folate and homocysteine concentrations and the methylenetetrahydrofolate reductase (MTHFR) 677C>T and 1298A>C polymorphisms to the risk of developing CRC. Subjects: Subjects were 226 cases and 437 matched referents from the population-based Northern Sweden Health and Disease Cohort. Results: We observed a bell-shaped association between plasma folate concentrations and CRC risk; multivariate odds ratio for middle versus lowest quintile 2.00 (95% CI 1.13-3.56). In subjects with follow-up times greater than the median of 4.2 years, however, plasma folate concentrations were strongly, positively related to CRC risk; multivariate odds ratio for highest versus lowest quintile 3.87 (95% CI 1.52-9.87, P-trend=0.007). Homocysteine was not associated with CRC risk. Multivariate odds ratios for the MTHFR polymorphisms were, for 677 TT versus CC, 0.41 (95% CI 0.19-0.85, P- trend=0.062) and, for 1298 CC versus AA, 1.62 (95% CI 0.94-2.81, P-trend=0.028). Interaction analysis suggested that the result for 1298A>C may have been largely due to linkage disequilibrium with 677C>T. The reduced CRC risk in 677 TT-homozygotes was independent of plasma folate status. Conclusions: Our findings suggest a decreased CRC risk in subjects with low folate status. This possibility of a detrimental component to the role of folate in carcinogenesis could have implications in the ongoing debate in Europe concerning mandatory folate fortification of foods. |
format |
Text |
author |
Van Guelpen, Bethany Hultdin, Johan Johansson, Ingegerd Hallmans, Göran Stenling, Roger Riboli, Elio Winkvist, Anna Palmqvist, Richard |
author_facet |
Van Guelpen, Bethany Hultdin, Johan Johansson, Ingegerd Hallmans, Göran Stenling, Roger Riboli, Elio Winkvist, Anna Palmqvist, Richard |
author_sort |
Van Guelpen, Bethany |
title |
Low folate levels may protect against colorectal cancer |
title_short |
Low folate levels may protect against colorectal cancer |
title_full |
Low folate levels may protect against colorectal cancer |
title_fullStr |
Low folate levels may protect against colorectal cancer |
title_full_unstemmed |
Low folate levels may protect against colorectal cancer |
title_sort |
low folate levels may protect against colorectal cancer |
publisher |
BMJ Publishing Group Ltd |
publishDate |
2006 |
url |
http://gut.bmj.com/cgi/content/short/gut.2005.085480v2 https://doi.org/10.1136/gut.2005.085480 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_relation |
http://gut.bmj.com/cgi/content/short/gut.2005.085480v2 http://dx.doi.org/10.1136/gut.2005.085480 |
op_rights |
Copyright (C) 2006, BMJ Publishing Group |
op_doi |
https://doi.org/10.1136/gut.2005.085480 |
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Gut |
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55 |
container_issue |
10 |
container_start_page |
1461 |
op_container_end_page |
1466 |
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1766147174650871808 |