Plasma insulin-like growth factor 1, insulin-like growth factor binding protein 3, and risk of colorectal cancer: a prospective study in northern Sweden
Background: Insulin-like growth factor 1 (IGF-1) has antiapoptotic and mitogenic effects on various cell types, and raised IGF-1 levels are increasingly being implicated as potential risk factors for cancer. Aims: To examine the relationship between IGF-1 and its major plasma binding protein, IGF bi...
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2002
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fthighwire:oai:open-archive.highwire.org:gutjnl:50/5/642 2023-05-15T17:44:27+02:00 Plasma insulin-like growth factor 1, insulin-like growth factor binding protein 3, and risk of colorectal cancer: a prospective study in northern Sweden Palmqvist, R Hallmans, G Rinaldi, S Biessy, C Stenling, R Riboli, E Kaaks, R 2002-05-01 00:00:00.0 text/html http://gut.bmj.com/cgi/content/short/50/5/642 https://doi.org/10.1136/gut.50.5.642 en eng BMJ Publishing Group Ltd http://gut.bmj.com/cgi/content/short/50/5/642 http://dx.doi.org/10.1136/gut.50.5.642 Copyright (C) 2002, BMJ Publishing Group Colorectal cancer TEXT 2002 fthighwire https://doi.org/10.1136/gut.50.5.642 2015-02-28T19:03:31Z Background: Insulin-like growth factor 1 (IGF-1) has antiapoptotic and mitogenic effects on various cell types, and raised IGF-1 levels are increasingly being implicated as potential risk factors for cancer. Aims: To examine the relationship between IGF-1 and its major plasma binding protein, IGF binding protein 3 (IGFBP-3), and the risk of colorectal cancer. Methods: We conducted a case-control study nested within the Northern Sweden Health and Disease Cohort. IGF-1 and IGFBP-3 were measured in prediagnostic plasma samples from 168 men and women who developed cancers of the colon (n=110) or rectum (n=58), and from 336 matched controls. Results: Conditional logistic regression analyses showed an increase in colon cancer risk with increasing levels of IGF-1 (odds ratios (ORs) 1.00, 1.89, 2.30, 2.66; p trend =0.03) and IGFBP-3 (ORs 1.00, 0.91, 1.80, 1.93; p trend =0.02). Rectal cancer risk was inversely related to levels of IGF-1 (ORs 1.00, 0.45, 0.33, 0.33; p trend =0.09) and IGFBP-3 (ORs 1.00, 0.75, 0.66, 0.49; p trend =0.21). Mutual adjustments between IGF-1 and IGFBP-3 did not materially alter these relationships. Conclusions: These results support earlier findings of increased risk of colon cancer in subjects with elevated plasma IGF-1. Our results however do not support the hypothesis that the risk of rectal cancer could also be directly related to IGF-1 levels. Text Northern Sweden HighWire Press (Stanford University) Gut 50 5 642 646 |
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HighWire Press (Stanford University) |
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English |
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Colorectal cancer |
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Colorectal cancer Palmqvist, R Hallmans, G Rinaldi, S Biessy, C Stenling, R Riboli, E Kaaks, R Plasma insulin-like growth factor 1, insulin-like growth factor binding protein 3, and risk of colorectal cancer: a prospective study in northern Sweden |
topic_facet |
Colorectal cancer |
description |
Background: Insulin-like growth factor 1 (IGF-1) has antiapoptotic and mitogenic effects on various cell types, and raised IGF-1 levels are increasingly being implicated as potential risk factors for cancer. Aims: To examine the relationship between IGF-1 and its major plasma binding protein, IGF binding protein 3 (IGFBP-3), and the risk of colorectal cancer. Methods: We conducted a case-control study nested within the Northern Sweden Health and Disease Cohort. IGF-1 and IGFBP-3 were measured in prediagnostic plasma samples from 168 men and women who developed cancers of the colon (n=110) or rectum (n=58), and from 336 matched controls. Results: Conditional logistic regression analyses showed an increase in colon cancer risk with increasing levels of IGF-1 (odds ratios (ORs) 1.00, 1.89, 2.30, 2.66; p trend =0.03) and IGFBP-3 (ORs 1.00, 0.91, 1.80, 1.93; p trend =0.02). Rectal cancer risk was inversely related to levels of IGF-1 (ORs 1.00, 0.45, 0.33, 0.33; p trend =0.09) and IGFBP-3 (ORs 1.00, 0.75, 0.66, 0.49; p trend =0.21). Mutual adjustments between IGF-1 and IGFBP-3 did not materially alter these relationships. Conclusions: These results support earlier findings of increased risk of colon cancer in subjects with elevated plasma IGF-1. Our results however do not support the hypothesis that the risk of rectal cancer could also be directly related to IGF-1 levels. |
format |
Text |
author |
Palmqvist, R Hallmans, G Rinaldi, S Biessy, C Stenling, R Riboli, E Kaaks, R |
author_facet |
Palmqvist, R Hallmans, G Rinaldi, S Biessy, C Stenling, R Riboli, E Kaaks, R |
author_sort |
Palmqvist, R |
title |
Plasma insulin-like growth factor 1, insulin-like growth factor binding protein 3, and risk of colorectal cancer: a prospective study in northern Sweden |
title_short |
Plasma insulin-like growth factor 1, insulin-like growth factor binding protein 3, and risk of colorectal cancer: a prospective study in northern Sweden |
title_full |
Plasma insulin-like growth factor 1, insulin-like growth factor binding protein 3, and risk of colorectal cancer: a prospective study in northern Sweden |
title_fullStr |
Plasma insulin-like growth factor 1, insulin-like growth factor binding protein 3, and risk of colorectal cancer: a prospective study in northern Sweden |
title_full_unstemmed |
Plasma insulin-like growth factor 1, insulin-like growth factor binding protein 3, and risk of colorectal cancer: a prospective study in northern Sweden |
title_sort |
plasma insulin-like growth factor 1, insulin-like growth factor binding protein 3, and risk of colorectal cancer: a prospective study in northern sweden |
publisher |
BMJ Publishing Group Ltd |
publishDate |
2002 |
url |
http://gut.bmj.com/cgi/content/short/50/5/642 https://doi.org/10.1136/gut.50.5.642 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_relation |
http://gut.bmj.com/cgi/content/short/50/5/642 http://dx.doi.org/10.1136/gut.50.5.642 |
op_rights |
Copyright (C) 2002, BMJ Publishing Group |
op_doi |
https://doi.org/10.1136/gut.50.5.642 |
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Gut |
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50 |
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5 |
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642 |
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646 |
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1766146670035206144 |