Immunoelectrophoretic studies on human small intestinal brush border proteins--amount of lactase protein in adult-type hypolactasia.

Jejunal biopsies from 15 Greenlandic and three Danish patients with adult type hypolactasia and nine Greenlandic and 15 Danish patients with normal lactase activity were analysed quantitatively for lactase protein by crossed immunoelectrophoresis. A constant correlation between the amount of lactase...

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Published in:Gut
Main Authors: Skovbjerg, H, Gudmand-Høyer, E, Fenger, H J
Format: Text
Language:English
Published: British Medical Journal Publishing Group 1980
Subjects:
Online Access:http://gut.bmj.com/cgi/content/short/21/5/360
https://doi.org/10.1136/gut.21.5.360
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spelling fthighwire:oai:open-archive.highwire.org:gutjnl:21/5/360 2023-05-15T16:31:08+02:00 Immunoelectrophoretic studies on human small intestinal brush border proteins--amount of lactase protein in adult-type hypolactasia. Skovbjerg, H Gudmand-Høyer, E Fenger, H J 1980-05-01 00:00:00.0 text/html http://gut.bmj.com/cgi/content/short/21/5/360 https://doi.org/10.1136/gut.21.5.360 en eng British Medical Journal Publishing Group http://gut.bmj.com/cgi/content/short/21/5/360 http://dx.doi.org/10.1136/gut.21.5.360 Copyright (C) 1980, BMJ Publishing Group Research Article TEXT 1980 fthighwire https://doi.org/10.1136/gut.21.5.360 2012-06-19T01:23:44Z Jejunal biopsies from 15 Greenlandic and three Danish patients with adult type hypolactasia and nine Greenlandic and 15 Danish patients with normal lactase activity were analysed quantitatively for lactase protein by crossed immunoelectrophoresis. A constant correlation between the amount of lactase activity and immunologically reactive lactase protein was demonstrated irrespective of the lactase activity level. As immunoelectrophoresis expresses the amount of enzyme protein independent of the enzymatic activity, it is concluded that the low enzymatic activity in adults with hypolactasia is caused by a low amount of lactase and not by a modified inactive enzyme. Text greenlandic HighWire Press (Stanford University) Gut 21 5 360 364
institution Open Polar
collection HighWire Press (Stanford University)
op_collection_id fthighwire
language English
topic Research Article
spellingShingle Research Article
Skovbjerg, H
Gudmand-Høyer, E
Fenger, H J
Immunoelectrophoretic studies on human small intestinal brush border proteins--amount of lactase protein in adult-type hypolactasia.
topic_facet Research Article
description Jejunal biopsies from 15 Greenlandic and three Danish patients with adult type hypolactasia and nine Greenlandic and 15 Danish patients with normal lactase activity were analysed quantitatively for lactase protein by crossed immunoelectrophoresis. A constant correlation between the amount of lactase activity and immunologically reactive lactase protein was demonstrated irrespective of the lactase activity level. As immunoelectrophoresis expresses the amount of enzyme protein independent of the enzymatic activity, it is concluded that the low enzymatic activity in adults with hypolactasia is caused by a low amount of lactase and not by a modified inactive enzyme.
format Text
author Skovbjerg, H
Gudmand-Høyer, E
Fenger, H J
author_facet Skovbjerg, H
Gudmand-Høyer, E
Fenger, H J
author_sort Skovbjerg, H
title Immunoelectrophoretic studies on human small intestinal brush border proteins--amount of lactase protein in adult-type hypolactasia.
title_short Immunoelectrophoretic studies on human small intestinal brush border proteins--amount of lactase protein in adult-type hypolactasia.
title_full Immunoelectrophoretic studies on human small intestinal brush border proteins--amount of lactase protein in adult-type hypolactasia.
title_fullStr Immunoelectrophoretic studies on human small intestinal brush border proteins--amount of lactase protein in adult-type hypolactasia.
title_full_unstemmed Immunoelectrophoretic studies on human small intestinal brush border proteins--amount of lactase protein in adult-type hypolactasia.
title_sort immunoelectrophoretic studies on human small intestinal brush border proteins--amount of lactase protein in adult-type hypolactasia.
publisher British Medical Journal Publishing Group
publishDate 1980
url http://gut.bmj.com/cgi/content/short/21/5/360
https://doi.org/10.1136/gut.21.5.360
genre greenlandic
genre_facet greenlandic
op_relation http://gut.bmj.com/cgi/content/short/21/5/360
http://dx.doi.org/10.1136/gut.21.5.360
op_rights Copyright (C) 1980, BMJ Publishing Group
op_doi https://doi.org/10.1136/gut.21.5.360
container_title Gut
container_volume 21
container_issue 5
container_start_page 360
op_container_end_page 364
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