Serum 25-hydroxyvitamin D and left ventricular systolic function in a non-smoking population: the Tromso Study
Aims The myocardium is considered to be an important target organ for parathyroid hormone and 1,25-dihydroxyvitamin D, the active metabolite of vitamin D. Vitamin D inadequacy has also been linked to cardiovascular morbidity. We aimed to evaluate the relationship between serum 25-hydroxyvitamin D [2...
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fthighwire:oai:open-archive.highwire.org:eurjhf:hfs210v1 2023-05-15T18:33:54+02:00 Serum 25-hydroxyvitamin D and left ventricular systolic function in a non-smoking population: the Tromso Study Kamycheva, Elena Wilsgaard, Tom Schirmer, Henrik Jorde, Rolf 2013-01-15 01:26:54.0 text/html http://eurjhf.oxfordjournals.org/cgi/content/short/hfs210v1 https://doi.org/10.1093/eurjhf/hfs210 en eng Oxford University Press http://eurjhf.oxfordjournals.org/cgi/content/short/hfs210v1 http://dx.doi.org/10.1093/eurjhf/hfs210 Copyright (C) 2013, European Society of Cardiology Article TEXT 2013 fthighwire https://doi.org/10.1093/eurjhf/hfs210 2013-05-27T09:28:13Z Aims The myocardium is considered to be an important target organ for parathyroid hormone and 1,25-dihydroxyvitamin D, the active metabolite of vitamin D. Vitamin D inadequacy has also been linked to cardiovascular morbidity. We aimed to evaluate the relationship between serum 25-hydroxyvitamin D [25(OH)D] and LV systolic function in a general population. Methods and results In the fourth Tromsø Study, M-mode echocardiography was performed in 2504 subjects with available serum 25(OH)D measurements. Measurements of EF and LV mass indexed by height (LVMH) were obtained. Only non-smoking men ( n = 790) and women ( n = 944) were included in the final analysis. Linear regression was used to assess the association between serum 25(OH)D and measurements of systolic function, and logistic regression was applied to assess the effect of serum 25(OH)D on the lowest quartile of EF (yes/no) and LV hypertrophy (LVH) (yes/no). We found no significant associations between vitamin D concentrations and measures of LV systolic function, when adjusted for other risk factors and the season when 25(OH)D sampling was performed [β –0.03, 95% confidence interval (CI) –0.08 to 0.03, and β –0.01, 95% CI –0.07 to 0.06 for LVMH and EF in men; and β 0.02, 95% CI –0.03 to 0.07, and β 0.01, 95% CI –0.05 to 0.07 for LVMH and EF in women]. Serum 25(OH)D did not predict EF and/or LVH in both genders. Conclusions In our population-based study, increased serum 25(OH)D was not associated with better LV systolic function, when adjusted for other risk factors and for season of vitamin D sampling. Text Tromso Tromso Tromsø HighWire Press (Stanford University) Tromso ENVELOPE(16.546,16.546,68.801,68.801) Tromsø European Journal of Heart Failure 15 5 490 495 |
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English |
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Article Kamycheva, Elena Wilsgaard, Tom Schirmer, Henrik Jorde, Rolf Serum 25-hydroxyvitamin D and left ventricular systolic function in a non-smoking population: the Tromso Study |
topic_facet |
Article |
description |
Aims The myocardium is considered to be an important target organ for parathyroid hormone and 1,25-dihydroxyvitamin D, the active metabolite of vitamin D. Vitamin D inadequacy has also been linked to cardiovascular morbidity. We aimed to evaluate the relationship between serum 25-hydroxyvitamin D [25(OH)D] and LV systolic function in a general population. Methods and results In the fourth Tromsø Study, M-mode echocardiography was performed in 2504 subjects with available serum 25(OH)D measurements. Measurements of EF and LV mass indexed by height (LVMH) were obtained. Only non-smoking men ( n = 790) and women ( n = 944) were included in the final analysis. Linear regression was used to assess the association between serum 25(OH)D and measurements of systolic function, and logistic regression was applied to assess the effect of serum 25(OH)D on the lowest quartile of EF (yes/no) and LV hypertrophy (LVH) (yes/no). We found no significant associations between vitamin D concentrations and measures of LV systolic function, when adjusted for other risk factors and the season when 25(OH)D sampling was performed [β –0.03, 95% confidence interval (CI) –0.08 to 0.03, and β –0.01, 95% CI –0.07 to 0.06 for LVMH and EF in men; and β 0.02, 95% CI –0.03 to 0.07, and β 0.01, 95% CI –0.05 to 0.07 for LVMH and EF in women]. Serum 25(OH)D did not predict EF and/or LVH in both genders. Conclusions In our population-based study, increased serum 25(OH)D was not associated with better LV systolic function, when adjusted for other risk factors and for season of vitamin D sampling. |
format |
Text |
author |
Kamycheva, Elena Wilsgaard, Tom Schirmer, Henrik Jorde, Rolf |
author_facet |
Kamycheva, Elena Wilsgaard, Tom Schirmer, Henrik Jorde, Rolf |
author_sort |
Kamycheva, Elena |
title |
Serum 25-hydroxyvitamin D and left ventricular systolic function in a non-smoking population: the Tromso Study |
title_short |
Serum 25-hydroxyvitamin D and left ventricular systolic function in a non-smoking population: the Tromso Study |
title_full |
Serum 25-hydroxyvitamin D and left ventricular systolic function in a non-smoking population: the Tromso Study |
title_fullStr |
Serum 25-hydroxyvitamin D and left ventricular systolic function in a non-smoking population: the Tromso Study |
title_full_unstemmed |
Serum 25-hydroxyvitamin D and left ventricular systolic function in a non-smoking population: the Tromso Study |
title_sort |
serum 25-hydroxyvitamin d and left ventricular systolic function in a non-smoking population: the tromso study |
publisher |
Oxford University Press |
publishDate |
2013 |
url |
http://eurjhf.oxfordjournals.org/cgi/content/short/hfs210v1 https://doi.org/10.1093/eurjhf/hfs210 |
long_lat |
ENVELOPE(16.546,16.546,68.801,68.801) |
geographic |
Tromso Tromsø |
geographic_facet |
Tromso Tromsø |
genre |
Tromso Tromso Tromsø |
genre_facet |
Tromso Tromso Tromsø |
op_relation |
http://eurjhf.oxfordjournals.org/cgi/content/short/hfs210v1 http://dx.doi.org/10.1093/eurjhf/hfs210 |
op_rights |
Copyright (C) 2013, European Society of Cardiology |
op_doi |
https://doi.org/10.1093/eurjhf/hfs210 |
container_title |
European Journal of Heart Failure |
container_volume |
15 |
container_issue |
5 |
container_start_page |
490 |
op_container_end_page |
495 |
_version_ |
1766218527759400960 |