Size at birth, weight gain over the life course, and low-grade inflammation in young adulthood: northern Finland 1966 birth cohort study
Aims Low-grade inflammation might mediate associations between size at birth, early life growth, excessive weight gain, and subsequent risk of cardiovascular disease in adult life. Our aim was to investigate relationships between fetal growth, weight over the life course, and low-grade inflammation...
Published in: | European Heart Journal |
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2008
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fthighwire:oai:open-archive.highwire.org:ehj:29/8/1049 2023-05-15T17:42:21+02:00 Size at birth, weight gain over the life course, and low-grade inflammation in young adulthood: northern Finland 1966 birth cohort study Tzoulaki, Ioanna Jarvelin, Marjo-Riitta Hartikainen, Anna-Liisa Leinonen, Maija Pouta, Anneli Paldanius, Mika Ruokonen, Aimo Canoy, Dexter Sovio, Ulla Saikku, Pekka Elliott, Paul 2008-04-02 00:00:00.0 text/html http://eurheartj.oxfordjournals.org/cgi/content/short/29/8/1049 https://doi.org/10.1093/eurheartj/ehn105 en eng Oxford University Press http://eurheartj.oxfordjournals.org/cgi/content/short/29/8/1049 http://dx.doi.org/10.1093/eurheartj/ehn105 Copyright (C) 2008, European Society of Cardiology Prevention and epidemiology TEXT 2008 fthighwire https://doi.org/10.1093/eurheartj/ehn105 2013-05-27T01:42:37Z Aims Low-grade inflammation might mediate associations between size at birth, early life growth, excessive weight gain, and subsequent risk of cardiovascular disease in adult life. Our aim was to investigate relationships between fetal growth, weight over the life course, and low-grade inflammation measured by serum high sensitivity C-reactive protein (CRP) levels at 31 years. Methods and results General population-based northern Finland 1966 Birth Cohort study of 5840 participants attending a clinical examination at 31 years, including measurement of CRP. Weight and height were assessed at birth, 12 months, and 14 and 31 years of age. CRP levels at 31 years were 16% [95% confidence interval (CI) 8, 23] higher per 1 kg lower birth weight, 21% (95% CI 2, 37) higher per 10 cm lower birth length, and 24% (95% CI 10, 36) higher per 1 kg/m3 lower ponderal index, after adjustment for potential confounders. Participants with highest tertile body mass index (BMI) at 31 years and lowest tertile birth weight had the highest average CRP levels. Per unit increase in BMI from 14 to 31 years was associated with 16% (95% CI 14, 17) higher CRP levels; the association was larger for those in the top BMI tertile at age 14 years. Conclusion Systemic low-grade inflammation may lie on the causal pathway that relates impaired fetal growth and weight gain from childhood to adulthood to adverse adult cardiovascular health. Lifestyle changes from early life might be an important step in reducing cardiovascular risk in adults. Text Northern Finland HighWire Press (Stanford University) European Heart Journal 29 8 1049 1056 |
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HighWire Press (Stanford University) |
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fthighwire |
language |
English |
topic |
Prevention and epidemiology |
spellingShingle |
Prevention and epidemiology Tzoulaki, Ioanna Jarvelin, Marjo-Riitta Hartikainen, Anna-Liisa Leinonen, Maija Pouta, Anneli Paldanius, Mika Ruokonen, Aimo Canoy, Dexter Sovio, Ulla Saikku, Pekka Elliott, Paul Size at birth, weight gain over the life course, and low-grade inflammation in young adulthood: northern Finland 1966 birth cohort study |
topic_facet |
Prevention and epidemiology |
description |
Aims Low-grade inflammation might mediate associations between size at birth, early life growth, excessive weight gain, and subsequent risk of cardiovascular disease in adult life. Our aim was to investigate relationships between fetal growth, weight over the life course, and low-grade inflammation measured by serum high sensitivity C-reactive protein (CRP) levels at 31 years. Methods and results General population-based northern Finland 1966 Birth Cohort study of 5840 participants attending a clinical examination at 31 years, including measurement of CRP. Weight and height were assessed at birth, 12 months, and 14 and 31 years of age. CRP levels at 31 years were 16% [95% confidence interval (CI) 8, 23] higher per 1 kg lower birth weight, 21% (95% CI 2, 37) higher per 10 cm lower birth length, and 24% (95% CI 10, 36) higher per 1 kg/m3 lower ponderal index, after adjustment for potential confounders. Participants with highest tertile body mass index (BMI) at 31 years and lowest tertile birth weight had the highest average CRP levels. Per unit increase in BMI from 14 to 31 years was associated with 16% (95% CI 14, 17) higher CRP levels; the association was larger for those in the top BMI tertile at age 14 years. Conclusion Systemic low-grade inflammation may lie on the causal pathway that relates impaired fetal growth and weight gain from childhood to adulthood to adverse adult cardiovascular health. Lifestyle changes from early life might be an important step in reducing cardiovascular risk in adults. |
format |
Text |
author |
Tzoulaki, Ioanna Jarvelin, Marjo-Riitta Hartikainen, Anna-Liisa Leinonen, Maija Pouta, Anneli Paldanius, Mika Ruokonen, Aimo Canoy, Dexter Sovio, Ulla Saikku, Pekka Elliott, Paul |
author_facet |
Tzoulaki, Ioanna Jarvelin, Marjo-Riitta Hartikainen, Anna-Liisa Leinonen, Maija Pouta, Anneli Paldanius, Mika Ruokonen, Aimo Canoy, Dexter Sovio, Ulla Saikku, Pekka Elliott, Paul |
author_sort |
Tzoulaki, Ioanna |
title |
Size at birth, weight gain over the life course, and low-grade inflammation in young adulthood: northern Finland 1966 birth cohort study |
title_short |
Size at birth, weight gain over the life course, and low-grade inflammation in young adulthood: northern Finland 1966 birth cohort study |
title_full |
Size at birth, weight gain over the life course, and low-grade inflammation in young adulthood: northern Finland 1966 birth cohort study |
title_fullStr |
Size at birth, weight gain over the life course, and low-grade inflammation in young adulthood: northern Finland 1966 birth cohort study |
title_full_unstemmed |
Size at birth, weight gain over the life course, and low-grade inflammation in young adulthood: northern Finland 1966 birth cohort study |
title_sort |
size at birth, weight gain over the life course, and low-grade inflammation in young adulthood: northern finland 1966 birth cohort study |
publisher |
Oxford University Press |
publishDate |
2008 |
url |
http://eurheartj.oxfordjournals.org/cgi/content/short/29/8/1049 https://doi.org/10.1093/eurheartj/ehn105 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_relation |
http://eurheartj.oxfordjournals.org/cgi/content/short/29/8/1049 http://dx.doi.org/10.1093/eurheartj/ehn105 |
op_rights |
Copyright (C) 2008, European Society of Cardiology |
op_doi |
https://doi.org/10.1093/eurheartj/ehn105 |
container_title |
European Heart Journal |
container_volume |
29 |
container_issue |
8 |
container_start_page |
1049 |
op_container_end_page |
1056 |
_version_ |
1766144192135823360 |