South-to-North gradient in lipid peroxidation in men with stable coronary artery disease in Europe
Aims A South-to-North gradient across Europe exists for the incidence of coronary artery disease (CAD) rates. Low-density lipoprotein (LDL) oxidation is a hallmark of atherosclerosis and CAD development. The aim of our study was to determine whether differences exist in the degree of LDL oxidation i...
Published in: | European Heart Journal |
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fthighwire:oai:open-archive.highwire.org:ehj:28/23/2841 2023-05-15T17:42:35+02:00 South-to-North gradient in lipid peroxidation in men with stable coronary artery disease in Europe Grau, María Guxens, Mònica Subirana, Isaac Fitó, Montserrat Covas, María-Isabel Jacquemin, Benedicte Sunyer, Jordi Lanki, Timo Picciotto, Sally Bellander, Tom Katsouyanni, Klea Schneider, Alexandra Peters, Annette Marrugat, Jaume on behalf of the AIRGENE Study Group 2007-12-01 00:00:00.0 text/html http://eurheartj.oxfordjournals.org/cgi/content/short/28/23/2841 https://doi.org/10.1093/eurheartj/ehm446 en eng Oxford University Press http://eurheartj.oxfordjournals.org/cgi/content/short/28/23/2841 http://dx.doi.org/10.1093/eurheartj/ehm446 Copyright (C) 2007, European Society of Cardiology Coronary heart disease TEXT 2007 fthighwire https://doi.org/10.1093/eurheartj/ehm446 2013-05-28T09:59:21Z Aims A South-to-North gradient across Europe exists for the incidence of coronary artery disease (CAD) rates. Low-density lipoprotein (LDL) oxidation is a hallmark of atherosclerosis and CAD development. The aim of our study was to determine whether differences exist in the degree of LDL oxidation in stable CAD patients from different regions of Europe. Methods and results A cross-sectional multicentre study included 790 stable CAD male subjects aged 35–79 years (61.4 ± 9.5) from six European countries in three regions by latitude: Northern (Finland and Sweden), Central (Germany), and Southern (Greece, Spain, and Italy). Plasma oxidized LDL (oxLDL) levels were determined. Alcohol intake and lipid profile were significantly associated with oxLDL. The Italian participants had the highest oxLDL levels. A sensitivity analysis showed the models yielded higher adjusted oxLDL values in Northern (63.8 U/L) than in Central (57.6 U/L) and Southern populations (56.5 U/L), P < 0.001, after excluding Italian subjects. The probability of Southern Europe scoring the lowest oxLDL levels was >71% in all fitted models. Conclusion Our findings suggest a gradient in LDL oxidation from Southern to Northern Europe that consistently holds for all levels of LDL, except for Italy; this country displays the highest levels in Europe, for unknown reasons. Text Northern Finland HighWire Press (Stanford University) European Heart Journal 28 23 2841 2849 |
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HighWire Press (Stanford University) |
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fthighwire |
language |
English |
topic |
Coronary heart disease |
spellingShingle |
Coronary heart disease Grau, María Guxens, Mònica Subirana, Isaac Fitó, Montserrat Covas, María-Isabel Jacquemin, Benedicte Sunyer, Jordi Lanki, Timo Picciotto, Sally Bellander, Tom Katsouyanni, Klea Schneider, Alexandra Peters, Annette Marrugat, Jaume on behalf of the AIRGENE Study Group South-to-North gradient in lipid peroxidation in men with stable coronary artery disease in Europe |
topic_facet |
Coronary heart disease |
description |
Aims A South-to-North gradient across Europe exists for the incidence of coronary artery disease (CAD) rates. Low-density lipoprotein (LDL) oxidation is a hallmark of atherosclerosis and CAD development. The aim of our study was to determine whether differences exist in the degree of LDL oxidation in stable CAD patients from different regions of Europe. Methods and results A cross-sectional multicentre study included 790 stable CAD male subjects aged 35–79 years (61.4 ± 9.5) from six European countries in three regions by latitude: Northern (Finland and Sweden), Central (Germany), and Southern (Greece, Spain, and Italy). Plasma oxidized LDL (oxLDL) levels were determined. Alcohol intake and lipid profile were significantly associated with oxLDL. The Italian participants had the highest oxLDL levels. A sensitivity analysis showed the models yielded higher adjusted oxLDL values in Northern (63.8 U/L) than in Central (57.6 U/L) and Southern populations (56.5 U/L), P < 0.001, after excluding Italian subjects. The probability of Southern Europe scoring the lowest oxLDL levels was >71% in all fitted models. Conclusion Our findings suggest a gradient in LDL oxidation from Southern to Northern Europe that consistently holds for all levels of LDL, except for Italy; this country displays the highest levels in Europe, for unknown reasons. |
format |
Text |
author |
Grau, María Guxens, Mònica Subirana, Isaac Fitó, Montserrat Covas, María-Isabel Jacquemin, Benedicte Sunyer, Jordi Lanki, Timo Picciotto, Sally Bellander, Tom Katsouyanni, Klea Schneider, Alexandra Peters, Annette Marrugat, Jaume on behalf of the AIRGENE Study Group |
author_facet |
Grau, María Guxens, Mònica Subirana, Isaac Fitó, Montserrat Covas, María-Isabel Jacquemin, Benedicte Sunyer, Jordi Lanki, Timo Picciotto, Sally Bellander, Tom Katsouyanni, Klea Schneider, Alexandra Peters, Annette Marrugat, Jaume on behalf of the AIRGENE Study Group |
author_sort |
Grau, María |
title |
South-to-North gradient in lipid peroxidation in men with stable coronary artery disease in Europe |
title_short |
South-to-North gradient in lipid peroxidation in men with stable coronary artery disease in Europe |
title_full |
South-to-North gradient in lipid peroxidation in men with stable coronary artery disease in Europe |
title_fullStr |
South-to-North gradient in lipid peroxidation in men with stable coronary artery disease in Europe |
title_full_unstemmed |
South-to-North gradient in lipid peroxidation in men with stable coronary artery disease in Europe |
title_sort |
south-to-north gradient in lipid peroxidation in men with stable coronary artery disease in europe |
publisher |
Oxford University Press |
publishDate |
2007 |
url |
http://eurheartj.oxfordjournals.org/cgi/content/short/28/23/2841 https://doi.org/10.1093/eurheartj/ehm446 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_relation |
http://eurheartj.oxfordjournals.org/cgi/content/short/28/23/2841 http://dx.doi.org/10.1093/eurheartj/ehm446 |
op_rights |
Copyright (C) 2007, European Society of Cardiology |
op_doi |
https://doi.org/10.1093/eurheartj/ehm446 |
container_title |
European Heart Journal |
container_volume |
28 |
container_issue |
23 |
container_start_page |
2841 |
op_container_end_page |
2849 |
_version_ |
1766144473884000256 |