Insights into SEN Virus Prevalence, Transmission, and Treatment in Community-Based Persons and Patients with Liver Disease Referred to a Liver Disease Unit
To document the prevalence and routes of transmission of SEN virus (SEN-V) in community-based individuals and patients referred to a liver disease unit, stored serum samples obtained from 160 Canadian Inuit and 140 patients with liver disease were tested for SEN-V DNA by polymerase chain reaction. I...
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fthighwire:oai:open-archive.highwire.org:cid:35/7/789 2023-05-15T16:55:13+02:00 Insights into SEN Virus Prevalence, Transmission, and Treatment in Community-Based Persons and Patients with Liver Disease Referred to a Liver Disease Unit Wong, Steve G. Primi, Daniele Kojima, Hiroshige Sottini, Alessandra Giulivi, Antonio Zhang, Manna Uhanova, Julia Minuk, Gerald Y. 2002-10-01 00:00:00.0 text/html http://cid.oxfordjournals.org/cgi/content/short/35/7/789 https://doi.org/10.1086/342329 en eng Oxford University Press http://cid.oxfordjournals.org/cgi/content/short/35/7/789 http://dx.doi.org/10.1086/342329 Copyright (C) 2002, Infectious Diseases Society of America Major Articles TEXT 2002 fthighwire https://doi.org/10.1086/342329 2013-05-28T10:05:04Z To document the prevalence and routes of transmission of SEN virus (SEN-V) in community-based individuals and patients referred to a liver disease unit, stored serum samples obtained from 160 Canadian Inuit and 140 patients with liver disease were tested for SEN-V DNA by polymerase chain reaction. In the community-based population, SEN-V was present in 57 (36%) of 160 persons. SEN-V—positive individuals tended to be younger and were more often male. Liver enzyme levels and serologic markers for hepatitis A and B viruses were similar in SEN-V—positive and SEN-V—negative individuals. SEN-V was present in 30 (21%) of the 140 patients with liver disease. Age, sex, risk factors for viral acquisition, prevalence of symptoms, and liver biochemical and histological findings were similar in SEN-V—positive and SEN-V—negative patients. These results indicate that SEN-V infection is a common viral infection in both healthy individuals and patients with chronic liver disease, that transmission likely occurs via nonparenteral routes, and that SEN-V infection is not associated with higher rates of or more-severe liver disease in persons with preexisting liver disease. Text inuit HighWire Press (Stanford University) Clinical Infectious Diseases 35 7 789 795 |
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Major Articles Wong, Steve G. Primi, Daniele Kojima, Hiroshige Sottini, Alessandra Giulivi, Antonio Zhang, Manna Uhanova, Julia Minuk, Gerald Y. Insights into SEN Virus Prevalence, Transmission, and Treatment in Community-Based Persons and Patients with Liver Disease Referred to a Liver Disease Unit |
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Major Articles |
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To document the prevalence and routes of transmission of SEN virus (SEN-V) in community-based individuals and patients referred to a liver disease unit, stored serum samples obtained from 160 Canadian Inuit and 140 patients with liver disease were tested for SEN-V DNA by polymerase chain reaction. In the community-based population, SEN-V was present in 57 (36%) of 160 persons. SEN-V—positive individuals tended to be younger and were more often male. Liver enzyme levels and serologic markers for hepatitis A and B viruses were similar in SEN-V—positive and SEN-V—negative individuals. SEN-V was present in 30 (21%) of the 140 patients with liver disease. Age, sex, risk factors for viral acquisition, prevalence of symptoms, and liver biochemical and histological findings were similar in SEN-V—positive and SEN-V—negative patients. These results indicate that SEN-V infection is a common viral infection in both healthy individuals and patients with chronic liver disease, that transmission likely occurs via nonparenteral routes, and that SEN-V infection is not associated with higher rates of or more-severe liver disease in persons with preexisting liver disease. |
format |
Text |
author |
Wong, Steve G. Primi, Daniele Kojima, Hiroshige Sottini, Alessandra Giulivi, Antonio Zhang, Manna Uhanova, Julia Minuk, Gerald Y. |
author_facet |
Wong, Steve G. Primi, Daniele Kojima, Hiroshige Sottini, Alessandra Giulivi, Antonio Zhang, Manna Uhanova, Julia Minuk, Gerald Y. |
author_sort |
Wong, Steve G. |
title |
Insights into SEN Virus Prevalence, Transmission, and Treatment in Community-Based Persons and Patients with Liver Disease Referred to a Liver Disease Unit |
title_short |
Insights into SEN Virus Prevalence, Transmission, and Treatment in Community-Based Persons and Patients with Liver Disease Referred to a Liver Disease Unit |
title_full |
Insights into SEN Virus Prevalence, Transmission, and Treatment in Community-Based Persons and Patients with Liver Disease Referred to a Liver Disease Unit |
title_fullStr |
Insights into SEN Virus Prevalence, Transmission, and Treatment in Community-Based Persons and Patients with Liver Disease Referred to a Liver Disease Unit |
title_full_unstemmed |
Insights into SEN Virus Prevalence, Transmission, and Treatment in Community-Based Persons and Patients with Liver Disease Referred to a Liver Disease Unit |
title_sort |
insights into sen virus prevalence, transmission, and treatment in community-based persons and patients with liver disease referred to a liver disease unit |
publisher |
Oxford University Press |
publishDate |
2002 |
url |
http://cid.oxfordjournals.org/cgi/content/short/35/7/789 https://doi.org/10.1086/342329 |
genre |
inuit |
genre_facet |
inuit |
op_relation |
http://cid.oxfordjournals.org/cgi/content/short/35/7/789 http://dx.doi.org/10.1086/342329 |
op_rights |
Copyright (C) 2002, Infectious Diseases Society of America |
op_doi |
https://doi.org/10.1086/342329 |
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Clinical Infectious Diseases |
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35 |
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7 |
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789 |
op_container_end_page |
795 |
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1766046198740811776 |