Effect of a Prudhoe Bay crude oil on hepatic and renal peroxisomal {beta}-oxidation and mixed-function oxidase activities in rats
The effect of oral administration of a Prudhoe Bay crude oil (PBCO) to male rats (PBCO, 2.6 g/kg body weight, daily) for 5–12 days on hepatic and renal microsomal mono-oxygenase activities and peroxisomal β-oxidation has been investigated. PBCO administration leads to liver enlargement. This is asso...
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Oxford University Press
1989
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Online Access: | http://carcin.oxfordjournals.org/cgi/content/short/10/2/269 https://doi.org/10.1093/carcin/10.2.269 |
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fthighwire:oai:open-archive.highwire.org:carcin:10/2/269 2023-05-15T18:03:37+02:00 Effect of a Prudhoe Bay crude oil on hepatic and renal peroxisomal {beta}-oxidation and mixed-function oxidase activities in rats Khan, S. Codner, M. Payne, J.F. Rahimtula, A.D. 1989-02-01 00:00:00.0 text/html http://carcin.oxfordjournals.org/cgi/content/short/10/2/269 https://doi.org/10.1093/carcin/10.2.269 en eng Oxford University Press http://carcin.oxfordjournals.org/cgi/content/short/10/2/269 http://dx.doi.org/10.1093/carcin/10.2.269 Copyright (C) 1989, Oxford University Press ORIGINAL ARTICLES TEXT 1989 fthighwire https://doi.org/10.1093/carcin/10.2.269 2013-05-27T11:18:13Z The effect of oral administration of a Prudhoe Bay crude oil (PBCO) to male rats (PBCO, 2.6 g/kg body weight, daily) for 5–12 days on hepatic and renal microsomal mono-oxygenase activities and peroxisomal β-oxidation has been investigated. PBCO administration leads to liver enlargement. This is associated with induction of microsomal cytochrome P-450 levels (1.6- to 2.0-fold) and dependent mixed-function oxidase activities (7-ethoxyresorufin- O -deethylase and 7-pentoxyresorufin- O -depentylase, representing cytochrome P-450I and cytochrome P-450IIB isoenzymes respectively, 9-to 15-fold; ω-oxidation of lauric acid representing the cytochrome P-450IVA1 isoenzyme, 1.4- to 1.5-fold) along with peroxisomal β-oxidation (palmitoyl CoA oxidation, 2- to 5-fold). It was observed that rats exposed to PBCO showed an increase in renal microsomal cytochrome P-450 content (1.6- to 2.3-fold), cytochrome P-450I activity (5- to 8-fold) and ω-oxidation activity (1.3- to 1.4-fold). However, renal peroxisomal β-oxidation was unaltered. Serum total triglycerides were lowered by 41–46% after PBCO exposure. These results suggest that induction of peroxisomal β-oxidation and possibly mono-oxygenases may be related to the carcinogenic/tumorigenic potential of crude oil. Text Prudhoe Bay HighWire Press (Stanford University) Carcinogenesis 10 2 269 272 |
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HighWire Press (Stanford University) |
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English |
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ORIGINAL ARTICLES |
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ORIGINAL ARTICLES Khan, S. Codner, M. Payne, J.F. Rahimtula, A.D. Effect of a Prudhoe Bay crude oil on hepatic and renal peroxisomal {beta}-oxidation and mixed-function oxidase activities in rats |
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ORIGINAL ARTICLES |
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The effect of oral administration of a Prudhoe Bay crude oil (PBCO) to male rats (PBCO, 2.6 g/kg body weight, daily) for 5–12 days on hepatic and renal microsomal mono-oxygenase activities and peroxisomal β-oxidation has been investigated. PBCO administration leads to liver enlargement. This is associated with induction of microsomal cytochrome P-450 levels (1.6- to 2.0-fold) and dependent mixed-function oxidase activities (7-ethoxyresorufin- O -deethylase and 7-pentoxyresorufin- O -depentylase, representing cytochrome P-450I and cytochrome P-450IIB isoenzymes respectively, 9-to 15-fold; ω-oxidation of lauric acid representing the cytochrome P-450IVA1 isoenzyme, 1.4- to 1.5-fold) along with peroxisomal β-oxidation (palmitoyl CoA oxidation, 2- to 5-fold). It was observed that rats exposed to PBCO showed an increase in renal microsomal cytochrome P-450 content (1.6- to 2.3-fold), cytochrome P-450I activity (5- to 8-fold) and ω-oxidation activity (1.3- to 1.4-fold). However, renal peroxisomal β-oxidation was unaltered. Serum total triglycerides were lowered by 41–46% after PBCO exposure. These results suggest that induction of peroxisomal β-oxidation and possibly mono-oxygenases may be related to the carcinogenic/tumorigenic potential of crude oil. |
format |
Text |
author |
Khan, S. Codner, M. Payne, J.F. Rahimtula, A.D. |
author_facet |
Khan, S. Codner, M. Payne, J.F. Rahimtula, A.D. |
author_sort |
Khan, S. |
title |
Effect of a Prudhoe Bay crude oil on hepatic and renal peroxisomal {beta}-oxidation and mixed-function oxidase activities in rats |
title_short |
Effect of a Prudhoe Bay crude oil on hepatic and renal peroxisomal {beta}-oxidation and mixed-function oxidase activities in rats |
title_full |
Effect of a Prudhoe Bay crude oil on hepatic and renal peroxisomal {beta}-oxidation and mixed-function oxidase activities in rats |
title_fullStr |
Effect of a Prudhoe Bay crude oil on hepatic and renal peroxisomal {beta}-oxidation and mixed-function oxidase activities in rats |
title_full_unstemmed |
Effect of a Prudhoe Bay crude oil on hepatic and renal peroxisomal {beta}-oxidation and mixed-function oxidase activities in rats |
title_sort |
effect of a prudhoe bay crude oil on hepatic and renal peroxisomal {beta}-oxidation and mixed-function oxidase activities in rats |
publisher |
Oxford University Press |
publishDate |
1989 |
url |
http://carcin.oxfordjournals.org/cgi/content/short/10/2/269 https://doi.org/10.1093/carcin/10.2.269 |
genre |
Prudhoe Bay |
genre_facet |
Prudhoe Bay |
op_relation |
http://carcin.oxfordjournals.org/cgi/content/short/10/2/269 http://dx.doi.org/10.1093/carcin/10.2.269 |
op_rights |
Copyright (C) 1989, Oxford University Press |
op_doi |
https://doi.org/10.1093/carcin/10.2.269 |
container_title |
Carcinogenesis |
container_volume |
10 |
container_issue |
2 |
container_start_page |
269 |
op_container_end_page |
272 |
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1766174550158999552 |