Hypothetical interventions and risk of myocardial infarction in a general population: application of the parametric g-formula in a longitudinal cohort study--the Tromso Study
Objectives The aim of this study was to use the parametric g-formula to estimate the 19-year risk of myocardial infarction (MI) under hypothetical interventions on six cardiovascular risk factors. Design and setting A populations-based cohort study with repeated measurements, the Tromsø Study. Prima...
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fthighwire:oai:open-archive.highwire.org:bmjopen:10/5/e035584 2023-05-15T18:33:53+02:00 Hypothetical interventions and risk of myocardial infarction in a general population: application of the parametric g-formula in a longitudinal cohort study--the Tromso Study Wilsgaard, Tom Vangen-Lønne, Anne Merete Mathiesen, Ellisiv Løchen, Maja-Lisa Njølstad, Inger Heiss, Gerardo Danaei, Goodarz 2020-05-24 06:01:56.0 text/html http://bmjopen.bmj.com/cgi/content/short/10/5/e035584 https://doi.org/10.1136/bmjopen-2019-035584 en eng BMJ Publishing Group Ltd http://bmjopen.bmj.com/cgi/content/short/10/5/e035584 http://dx.doi.org/10.1136/bmjopen-2019-035584 Copyright (C) 2020, British Medical Journal Publishing Group Epidemiology TEXT 2020 fthighwire https://doi.org/10.1136/bmjopen-2019-035584 2020-06-16T09:49:40Z Objectives The aim of this study was to use the parametric g-formula to estimate the 19-year risk of myocardial infarction (MI) under hypothetical interventions on six cardiovascular risk factors. Design and setting A populations-based cohort study with repeated measurements, the Tromsø Study. Primary outcome measure Myocardial infarction. Participants We estimated the relative and absolute risk reduction under feasible and intensive risk reduction strategies for smoking, physical activity, alcohol drinking, body mass index, total serum cholesterol and systolic blood pressure in 14 965 men and women with 19 years of follow-up (1994–2013). Results The estimated 19-year risk of MI under no intervention was 7.5% in individuals with baseline mean age 49.3 years (range 25–69). This risk was reduced by 30% (95% CI 19% to 39%) under joint feasible interventions on all risk factors, and 70% (60%, 78%) under a set of more intensive interventions. The most effective interventions were lowering of total cholesterol to 5.18 mmol/L and lowering of systolic blood pressure to 120 mm Hg (33% and 37% lower MI risk, respectively). The absolute risk reductions were significantly larger in men, in older participants, in smokers and in those with low education. Conclusion Modification of population levels of cardiovascular risk factors could have prevented close to one-third of the cases of MI in the municipality of Tromsø during 19 years of follow-up. Text Tromso Tromso Tromsø HighWire Press (Stanford University) Tromso ENVELOPE(16.546,16.546,68.801,68.801) Tromsø BMJ Open 10 5 e035584 |
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HighWire Press (Stanford University) |
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English |
topic |
Epidemiology |
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Epidemiology Wilsgaard, Tom Vangen-Lønne, Anne Merete Mathiesen, Ellisiv Løchen, Maja-Lisa Njølstad, Inger Heiss, Gerardo Danaei, Goodarz Hypothetical interventions and risk of myocardial infarction in a general population: application of the parametric g-formula in a longitudinal cohort study--the Tromso Study |
topic_facet |
Epidemiology |
description |
Objectives The aim of this study was to use the parametric g-formula to estimate the 19-year risk of myocardial infarction (MI) under hypothetical interventions on six cardiovascular risk factors. Design and setting A populations-based cohort study with repeated measurements, the Tromsø Study. Primary outcome measure Myocardial infarction. Participants We estimated the relative and absolute risk reduction under feasible and intensive risk reduction strategies for smoking, physical activity, alcohol drinking, body mass index, total serum cholesterol and systolic blood pressure in 14 965 men and women with 19 years of follow-up (1994–2013). Results The estimated 19-year risk of MI under no intervention was 7.5% in individuals with baseline mean age 49.3 years (range 25–69). This risk was reduced by 30% (95% CI 19% to 39%) under joint feasible interventions on all risk factors, and 70% (60%, 78%) under a set of more intensive interventions. The most effective interventions were lowering of total cholesterol to 5.18 mmol/L and lowering of systolic blood pressure to 120 mm Hg (33% and 37% lower MI risk, respectively). The absolute risk reductions were significantly larger in men, in older participants, in smokers and in those with low education. Conclusion Modification of population levels of cardiovascular risk factors could have prevented close to one-third of the cases of MI in the municipality of Tromsø during 19 years of follow-up. |
format |
Text |
author |
Wilsgaard, Tom Vangen-Lønne, Anne Merete Mathiesen, Ellisiv Løchen, Maja-Lisa Njølstad, Inger Heiss, Gerardo Danaei, Goodarz |
author_facet |
Wilsgaard, Tom Vangen-Lønne, Anne Merete Mathiesen, Ellisiv Løchen, Maja-Lisa Njølstad, Inger Heiss, Gerardo Danaei, Goodarz |
author_sort |
Wilsgaard, Tom |
title |
Hypothetical interventions and risk of myocardial infarction in a general population: application of the parametric g-formula in a longitudinal cohort study--the Tromso Study |
title_short |
Hypothetical interventions and risk of myocardial infarction in a general population: application of the parametric g-formula in a longitudinal cohort study--the Tromso Study |
title_full |
Hypothetical interventions and risk of myocardial infarction in a general population: application of the parametric g-formula in a longitudinal cohort study--the Tromso Study |
title_fullStr |
Hypothetical interventions and risk of myocardial infarction in a general population: application of the parametric g-formula in a longitudinal cohort study--the Tromso Study |
title_full_unstemmed |
Hypothetical interventions and risk of myocardial infarction in a general population: application of the parametric g-formula in a longitudinal cohort study--the Tromso Study |
title_sort |
hypothetical interventions and risk of myocardial infarction in a general population: application of the parametric g-formula in a longitudinal cohort study--the tromso study |
publisher |
BMJ Publishing Group Ltd |
publishDate |
2020 |
url |
http://bmjopen.bmj.com/cgi/content/short/10/5/e035584 https://doi.org/10.1136/bmjopen-2019-035584 |
long_lat |
ENVELOPE(16.546,16.546,68.801,68.801) |
geographic |
Tromso Tromsø |
geographic_facet |
Tromso Tromsø |
genre |
Tromso Tromso Tromsø |
genre_facet |
Tromso Tromso Tromsø |
op_relation |
http://bmjopen.bmj.com/cgi/content/short/10/5/e035584 http://dx.doi.org/10.1136/bmjopen-2019-035584 |
op_rights |
Copyright (C) 2020, British Medical Journal Publishing Group |
op_doi |
https://doi.org/10.1136/bmjopen-2019-035584 |
container_title |
BMJ Open |
container_volume |
10 |
container_issue |
5 |
container_start_page |
e035584 |
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1766218514449825792 |