Is Helicobacter pylori the cause of dyspepsia?
OBJECTIVE--To determine the association between infection with Helicobacter pylori and dyspepsia. DESIGN--Cross sectional study of dyspeptic subjects and age and sex matched controls identified by a questionnaire survey of all inhabitants aged 20-69. (Endoscopy, histological examination, and microbi...
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1992
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fthighwire:oai:open-archive.highwire.org:bmj:304/6837/1276 2023-05-15T18:30:00+02:00 Is Helicobacter pylori the cause of dyspepsia? Bernersen, B. Johnsen, R. Bostad, L. Straume, B. Sommer, A. I. Burhol, P. G. 1992-05-16 00:00:00.0 text/html http://www.bmj.com/cgi/content/short/304/6837/1276 https://doi.org/10.1136/bmj.304.6837.1276 en eng BMJ Publishing Group Ltd http://www.bmj.com/cgi/content/short/304/6837/1276 http://dx.doi.org/10.1136/bmj.304.6837.1276 Copyright (C) 1992, BMJ Publishing Group Ltd RESEARCH ARTICLE TEXT 1992 fthighwire https://doi.org/10.1136/bmj.304.6837.1276 2013-05-27T05:19:04Z OBJECTIVE--To determine the association between infection with Helicobacter pylori and dyspepsia. DESIGN--Cross sectional study of dyspeptic subjects and age and sex matched controls identified by a questionnaire survey of all inhabitants aged 20-69. (Endoscopy, histological examination, and microbiological examinations of biopsies from the gastric mucosa were performed blind.) SETTING--Population based survey in Sørreisa, Norway. SUBJECTS--All 782 dyspeptic subjects (excluding those with a previous history of peptic ulcer, gall stones or kidney stones, and coronary heart disease) and controls were offered an endoscopy, of whom 309 dyspeptic subjects and 310 controls attended. MAIN OUTCOME MEASURES--Prevalences of endoscopic and histological diagnoses and of cultures positive for H pylori. RESULTS--A high prevalence of positive cultures, increasing with age, was found in both dyspeptic subjects (48%) and non-dyspeptic controls (36%) (p = 0.004). Positive cultures in both dyspeptic subjects and controls were strongly associated with histological gastritis (70%, 95% confidence interval 65.5 to 85.3; 60%, 52.7 to 67.7, respectively) and peptic ulcer (92%, 61.5 to 99.8; 64.1, 9.4 to 99.2, respectively). Only 3% of subjects with a histologically non-inflamed gastric mucosa had this infection (dyspeptic subjects 2%, 0.2 to 7.0; controls 4%; 1.2 to 8.8). CONCLUSIONS--The relation between dyspeptic symptoms and H pylori is dubious; H pylori seems to have a pathogenetic role in gastritis and may be a contributing factor but not a cause of peptic ulcer. Text Sørreisa HighWire Press (Stanford University) Norway Sørreisa ENVELOPE(18.153,18.153,69.145,69.145) BMJ 304 6837 1276 1279 |
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RESEARCH ARTICLE Bernersen, B. Johnsen, R. Bostad, L. Straume, B. Sommer, A. I. Burhol, P. G. Is Helicobacter pylori the cause of dyspepsia? |
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RESEARCH ARTICLE |
description |
OBJECTIVE--To determine the association between infection with Helicobacter pylori and dyspepsia. DESIGN--Cross sectional study of dyspeptic subjects and age and sex matched controls identified by a questionnaire survey of all inhabitants aged 20-69. (Endoscopy, histological examination, and microbiological examinations of biopsies from the gastric mucosa were performed blind.) SETTING--Population based survey in Sørreisa, Norway. SUBJECTS--All 782 dyspeptic subjects (excluding those with a previous history of peptic ulcer, gall stones or kidney stones, and coronary heart disease) and controls were offered an endoscopy, of whom 309 dyspeptic subjects and 310 controls attended. MAIN OUTCOME MEASURES--Prevalences of endoscopic and histological diagnoses and of cultures positive for H pylori. RESULTS--A high prevalence of positive cultures, increasing with age, was found in both dyspeptic subjects (48%) and non-dyspeptic controls (36%) (p = 0.004). Positive cultures in both dyspeptic subjects and controls were strongly associated with histological gastritis (70%, 95% confidence interval 65.5 to 85.3; 60%, 52.7 to 67.7, respectively) and peptic ulcer (92%, 61.5 to 99.8; 64.1, 9.4 to 99.2, respectively). Only 3% of subjects with a histologically non-inflamed gastric mucosa had this infection (dyspeptic subjects 2%, 0.2 to 7.0; controls 4%; 1.2 to 8.8). CONCLUSIONS--The relation between dyspeptic symptoms and H pylori is dubious; H pylori seems to have a pathogenetic role in gastritis and may be a contributing factor but not a cause of peptic ulcer. |
format |
Text |
author |
Bernersen, B. Johnsen, R. Bostad, L. Straume, B. Sommer, A. I. Burhol, P. G. |
author_facet |
Bernersen, B. Johnsen, R. Bostad, L. Straume, B. Sommer, A. I. Burhol, P. G. |
author_sort |
Bernersen, B. |
title |
Is Helicobacter pylori the cause of dyspepsia? |
title_short |
Is Helicobacter pylori the cause of dyspepsia? |
title_full |
Is Helicobacter pylori the cause of dyspepsia? |
title_fullStr |
Is Helicobacter pylori the cause of dyspepsia? |
title_full_unstemmed |
Is Helicobacter pylori the cause of dyspepsia? |
title_sort |
is helicobacter pylori the cause of dyspepsia? |
publisher |
BMJ Publishing Group Ltd |
publishDate |
1992 |
url |
http://www.bmj.com/cgi/content/short/304/6837/1276 https://doi.org/10.1136/bmj.304.6837.1276 |
long_lat |
ENVELOPE(18.153,18.153,69.145,69.145) |
geographic |
Norway Sørreisa |
geographic_facet |
Norway Sørreisa |
genre |
Sørreisa |
genre_facet |
Sørreisa |
op_relation |
http://www.bmj.com/cgi/content/short/304/6837/1276 http://dx.doi.org/10.1136/bmj.304.6837.1276 |
op_rights |
Copyright (C) 1992, BMJ Publishing Group Ltd |
op_doi |
https://doi.org/10.1136/bmj.304.6837.1276 |
container_title |
BMJ |
container_volume |
304 |
container_issue |
6837 |
container_start_page |
1276 |
op_container_end_page |
1279 |
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1766213470155440128 |