Beneficial effect of fish oil on blood viscosity in peripheral vascular disease.
Reports suggest that the low incidence of ischaemic heart disease in Greenlandic Eskimos is related to the effect of a diet rich in eicosapentaenoic acid on platelet reactivity and plasma lipid concentrations. A double blind randomised investigation was therefore conducted of the effects on blood vi...
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1984
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fthighwire:oai:open-archive.highwire.org:bmj:288/6417/592 2023-05-15T16:06:57+02:00 Beneficial effect of fish oil on blood viscosity in peripheral vascular disease. Woodcock, B E Smith, E Lambert, W H Jones, W M Galloway, J H Greaves, M Preston, F E 1984-02-25 00:00:00.0 text/html http://www.bmj.com/cgi/content/short/288/6417/592 https://doi.org/10.1136/bmj.288.6417.592 en eng BMJ Publishing Group Ltd http://www.bmj.com/cgi/content/short/288/6417/592 http://dx.doi.org/10.1136/bmj.288.6417.592 Copyright (C) 1984, BMJ Publishing Group Ltd RESEARCH ARTICLE TEXT 1984 fthighwire https://doi.org/10.1136/bmj.288.6417.592 2015-02-28T13:05:48Z Reports suggest that the low incidence of ischaemic heart disease in Greenlandic Eskimos is related to the effect of a diet rich in eicosapentaenoic acid on platelet reactivity and plasma lipid concentrations. A double blind randomised investigation was therefore conducted of the effects on blood viscosity of dietary supplementation with an oil rich in this fatty acid (1.8 g/day, given as fish oil) and an eicosapentaenoic acid poor oil (as corn/olive oil) in patients with peripheral arterial disease. A statistically significant reduction in whole blood viscosity was observed at seven weeks in those patients receiving the eicosapentaenoic acid rich oil. No changes in plasma viscosity, haemoglobin concentration, packed cell volume, or platelet count were seen. A significant fall in plasma triglyceride concentration was also noted only in the patients receiving oil rich in eicosapentaenoic acid; plasma concentrations of cholesterol and high density lipoprotein cholesterol were unchanged. It is concluded that rheological changes that result from a diet rich in eicosapentaenoic acid may contribute to the suggested protective effects of such a diet against arterial disease and that such changes are of potential therapeutic importance in established arterial disease. Text eskimo* greenlandic HighWire Press (Stanford University) BMJ 288 6417 592 594 |
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RESEARCH ARTICLE |
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RESEARCH ARTICLE Woodcock, B E Smith, E Lambert, W H Jones, W M Galloway, J H Greaves, M Preston, F E Beneficial effect of fish oil on blood viscosity in peripheral vascular disease. |
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RESEARCH ARTICLE |
description |
Reports suggest that the low incidence of ischaemic heart disease in Greenlandic Eskimos is related to the effect of a diet rich in eicosapentaenoic acid on platelet reactivity and plasma lipid concentrations. A double blind randomised investigation was therefore conducted of the effects on blood viscosity of dietary supplementation with an oil rich in this fatty acid (1.8 g/day, given as fish oil) and an eicosapentaenoic acid poor oil (as corn/olive oil) in patients with peripheral arterial disease. A statistically significant reduction in whole blood viscosity was observed at seven weeks in those patients receiving the eicosapentaenoic acid rich oil. No changes in plasma viscosity, haemoglobin concentration, packed cell volume, or platelet count were seen. A significant fall in plasma triglyceride concentration was also noted only in the patients receiving oil rich in eicosapentaenoic acid; plasma concentrations of cholesterol and high density lipoprotein cholesterol were unchanged. It is concluded that rheological changes that result from a diet rich in eicosapentaenoic acid may contribute to the suggested protective effects of such a diet against arterial disease and that such changes are of potential therapeutic importance in established arterial disease. |
format |
Text |
author |
Woodcock, B E Smith, E Lambert, W H Jones, W M Galloway, J H Greaves, M Preston, F E |
author_facet |
Woodcock, B E Smith, E Lambert, W H Jones, W M Galloway, J H Greaves, M Preston, F E |
author_sort |
Woodcock, B E |
title |
Beneficial effect of fish oil on blood viscosity in peripheral vascular disease. |
title_short |
Beneficial effect of fish oil on blood viscosity in peripheral vascular disease. |
title_full |
Beneficial effect of fish oil on blood viscosity in peripheral vascular disease. |
title_fullStr |
Beneficial effect of fish oil on blood viscosity in peripheral vascular disease. |
title_full_unstemmed |
Beneficial effect of fish oil on blood viscosity in peripheral vascular disease. |
title_sort |
beneficial effect of fish oil on blood viscosity in peripheral vascular disease. |
publisher |
BMJ Publishing Group Ltd |
publishDate |
1984 |
url |
http://www.bmj.com/cgi/content/short/288/6417/592 https://doi.org/10.1136/bmj.288.6417.592 |
genre |
eskimo* greenlandic |
genre_facet |
eskimo* greenlandic |
op_relation |
http://www.bmj.com/cgi/content/short/288/6417/592 http://dx.doi.org/10.1136/bmj.288.6417.592 |
op_rights |
Copyright (C) 1984, BMJ Publishing Group Ltd |
op_doi |
https://doi.org/10.1136/bmj.288.6417.592 |
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BMJ |
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288 |
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6417 |
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592 |
op_container_end_page |
594 |
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1766402965631926272 |