The burden of genetically determined eye disease.
We determined the underlying aetiology of blindness for the registered blind population of the Province of Newfoundland and Labrador. In both 1981 and 1984 single-gene disorders accounted for 30% of total blindness and congenital defects for another 10-11%. Genetically determined conditions, diabete...
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1986
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fthighwire:oai:open-archive.highwire.org:bjophthalmol:70/9/696 2023-05-15T17:22:26+02:00 The burden of genetically determined eye disease. Green, J S Bear, J C Johnson, G J 1986-09-01 00:00:00.0 text/html http://bjo.bmj.com/cgi/content/short/70/9/696 https://doi.org/10.1136/bjo.70.9.696 en eng BMJ Publishing Group Ltd http://bjo.bmj.com/cgi/content/short/70/9/696 http://dx.doi.org/10.1136/bjo.70.9.696 Copyright (C) 1986, BMJ Publishing Group Ltd Research Article TEXT 1986 fthighwire https://doi.org/10.1136/bjo.70.9.696 2015-02-28T18:24:33Z We determined the underlying aetiology of blindness for the registered blind population of the Province of Newfoundland and Labrador. In both 1981 and 1984 single-gene disorders accounted for 30% of total blindness and congenital defects for another 10-11%. Genetically determined conditions, diabetes, and senile macular degeneration (SMD) were the three leading causes of registration in each year, 1980-4. We calculated mean ages of registration and mean ages of death over the last four years for five major aetiological groups. Patients with genetic conditions were registered at a much younger age and had a correspondingly longer duration of blindness (21 years as compared with 5 years for either diabetes or SMD). Total 'person-years of blindness' was then calculated from the product of this duration of blindness and the total numbers registered in each group. This index shows that the overall individual and population impact of monogenic blindness is overwhelmingly greater than that of other causes (6849 person-years compared with 270 for diabetes and 430 for SMD). In view of this frequency and duration of monogenic blindness, and also of the substantial hereditary liability to relatively common causes of blindness such as glaucoma, diabetic retinopathy, and high myopia, we suggest that more attention needs to be paid to elucidating the genetic contribution to blindness. Text Newfoundland HighWire Press (Stanford University) Newfoundland British Journal of Ophthalmology 70 9 696 699 |
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HighWire Press (Stanford University) |
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English |
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Research Article |
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Research Article Green, J S Bear, J C Johnson, G J The burden of genetically determined eye disease. |
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Research Article |
description |
We determined the underlying aetiology of blindness for the registered blind population of the Province of Newfoundland and Labrador. In both 1981 and 1984 single-gene disorders accounted for 30% of total blindness and congenital defects for another 10-11%. Genetically determined conditions, diabetes, and senile macular degeneration (SMD) were the three leading causes of registration in each year, 1980-4. We calculated mean ages of registration and mean ages of death over the last four years for five major aetiological groups. Patients with genetic conditions were registered at a much younger age and had a correspondingly longer duration of blindness (21 years as compared with 5 years for either diabetes or SMD). Total 'person-years of blindness' was then calculated from the product of this duration of blindness and the total numbers registered in each group. This index shows that the overall individual and population impact of monogenic blindness is overwhelmingly greater than that of other causes (6849 person-years compared with 270 for diabetes and 430 for SMD). In view of this frequency and duration of monogenic blindness, and also of the substantial hereditary liability to relatively common causes of blindness such as glaucoma, diabetic retinopathy, and high myopia, we suggest that more attention needs to be paid to elucidating the genetic contribution to blindness. |
format |
Text |
author |
Green, J S Bear, J C Johnson, G J |
author_facet |
Green, J S Bear, J C Johnson, G J |
author_sort |
Green, J S |
title |
The burden of genetically determined eye disease. |
title_short |
The burden of genetically determined eye disease. |
title_full |
The burden of genetically determined eye disease. |
title_fullStr |
The burden of genetically determined eye disease. |
title_full_unstemmed |
The burden of genetically determined eye disease. |
title_sort |
burden of genetically determined eye disease. |
publisher |
BMJ Publishing Group Ltd |
publishDate |
1986 |
url |
http://bjo.bmj.com/cgi/content/short/70/9/696 https://doi.org/10.1136/bjo.70.9.696 |
geographic |
Newfoundland |
geographic_facet |
Newfoundland |
genre |
Newfoundland |
genre_facet |
Newfoundland |
op_relation |
http://bjo.bmj.com/cgi/content/short/70/9/696 http://dx.doi.org/10.1136/bjo.70.9.696 |
op_rights |
Copyright (C) 1986, BMJ Publishing Group Ltd |
op_doi |
https://doi.org/10.1136/bjo.70.9.696 |
container_title |
British Journal of Ophthalmology |
container_volume |
70 |
container_issue |
9 |
container_start_page |
696 |
op_container_end_page |
699 |
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1766109097324707840 |