Relation between retinal vessel diameter and posterior segment optical coherence tomography variables in middle-aged Caucasians: the Northern Finland Birth Cohort Eye Study
Aims Studying the relationship between retinal vessel diameter (RVD) with (1) macular thickness and volume, (2) retinal nerve fibre layer (RNFL), (3) ganglion cell-inner plexiform layer (GC-IPL) and (4) optic nerve head (ONH) in a population cohort of middle-aged Caucasians. Methods We collected dat...
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fthighwire:oai:open-archive.highwire.org:bjophthalmol:104/10/1435 2023-05-15T17:42:46+02:00 Relation between retinal vessel diameter and posterior segment optical coherence tomography variables in middle-aged Caucasians: the Northern Finland Birth Cohort Eye Study Geneid, Mohamed I Uusitalo, Janne J Leiviskä, Ilmari L Saarela, Ville O Liinamaa, M Johanna 2020-10-01 00:00:00.0 text/html http://bjo.bmj.com/cgi/content/short/104/10/1435 https://doi.org/10.1136/bjophthalmol-2019-314803 en eng BMJ Publishing Group Ltd http://bjo.bmj.com/cgi/content/short/104/10/1435 http://dx.doi.org/10.1136/bjophthalmol-2019-314803 Copyright (C) 2020, BMJ Publishing Group Ltd Original articles - Clinical science TEXT 2020 fthighwire https://doi.org/10.1136/bjophthalmol-2019-314803 2020-09-30T06:06:19Z Aims Studying the relationship between retinal vessel diameter (RVD) with (1) macular thickness and volume, (2) retinal nerve fibre layer (RNFL), (3) ganglion cell-inner plexiform layer (GC-IPL) and (4) optic nerve head (ONH) in a population cohort of middle-aged Caucasians. Methods We collected data from 3070 individuals. We used a semiautomated computer-assisted programme to measure central retinal arteriolar equivalent and central retinal venular equivalent. Macular and ONH parameters were assessed by optical coherence tomography. Results Data from 2155 persons were analysed. A larger RVD was associated with a thicker macula and increased macular volume; each SD increase in average macular thickness and volume was associated with a 3.28 µm and a 3.19 µm increase in arteriolar diameter and a 5.10 µm and a 5.08 µm increase in venular diameter, respectively (p<0.001 for all). A larger rim area, greater GC-IPL and RNFL thicknesses were associated with larger RVD; each SD increase in rim area, GC-IPL thickness and RNFL thickness was associated with a 1.21 µm, 2.68 µm and a 3.29 µm increase in arteriolar diameter and a 2.13 µm, 4.02 µm and 5.04 µm increase in venular diameter, respectively (p<0.001 for all). Conclusions Increased macular thickness, macular volume, GC-IPL thickness, RNFL thickness and optic nerve rim area were associated with larger RVDs in all subjects. This study clarified the anatomical correlations between both macular and ONH parameters with RVD for middle-aged Caucasians; these can represent a basis for further studies investigating the vascular aetiology of eye diseases. Text Northern Finland HighWire Press (Stanford University) British Journal of Ophthalmology 104 10 1435 1442 |
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Original articles - Clinical science |
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Original articles - Clinical science Geneid, Mohamed I Uusitalo, Janne J Leiviskä, Ilmari L Saarela, Ville O Liinamaa, M Johanna Relation between retinal vessel diameter and posterior segment optical coherence tomography variables in middle-aged Caucasians: the Northern Finland Birth Cohort Eye Study |
topic_facet |
Original articles - Clinical science |
description |
Aims Studying the relationship between retinal vessel diameter (RVD) with (1) macular thickness and volume, (2) retinal nerve fibre layer (RNFL), (3) ganglion cell-inner plexiform layer (GC-IPL) and (4) optic nerve head (ONH) in a population cohort of middle-aged Caucasians. Methods We collected data from 3070 individuals. We used a semiautomated computer-assisted programme to measure central retinal arteriolar equivalent and central retinal venular equivalent. Macular and ONH parameters were assessed by optical coherence tomography. Results Data from 2155 persons were analysed. A larger RVD was associated with a thicker macula and increased macular volume; each SD increase in average macular thickness and volume was associated with a 3.28 µm and a 3.19 µm increase in arteriolar diameter and a 5.10 µm and a 5.08 µm increase in venular diameter, respectively (p<0.001 for all). A larger rim area, greater GC-IPL and RNFL thicknesses were associated with larger RVD; each SD increase in rim area, GC-IPL thickness and RNFL thickness was associated with a 1.21 µm, 2.68 µm and a 3.29 µm increase in arteriolar diameter and a 2.13 µm, 4.02 µm and 5.04 µm increase in venular diameter, respectively (p<0.001 for all). Conclusions Increased macular thickness, macular volume, GC-IPL thickness, RNFL thickness and optic nerve rim area were associated with larger RVDs in all subjects. This study clarified the anatomical correlations between both macular and ONH parameters with RVD for middle-aged Caucasians; these can represent a basis for further studies investigating the vascular aetiology of eye diseases. |
format |
Text |
author |
Geneid, Mohamed I Uusitalo, Janne J Leiviskä, Ilmari L Saarela, Ville O Liinamaa, M Johanna |
author_facet |
Geneid, Mohamed I Uusitalo, Janne J Leiviskä, Ilmari L Saarela, Ville O Liinamaa, M Johanna |
author_sort |
Geneid, Mohamed I |
title |
Relation between retinal vessel diameter and posterior segment optical coherence tomography variables in middle-aged Caucasians: the Northern Finland Birth Cohort Eye Study |
title_short |
Relation between retinal vessel diameter and posterior segment optical coherence tomography variables in middle-aged Caucasians: the Northern Finland Birth Cohort Eye Study |
title_full |
Relation between retinal vessel diameter and posterior segment optical coherence tomography variables in middle-aged Caucasians: the Northern Finland Birth Cohort Eye Study |
title_fullStr |
Relation between retinal vessel diameter and posterior segment optical coherence tomography variables in middle-aged Caucasians: the Northern Finland Birth Cohort Eye Study |
title_full_unstemmed |
Relation between retinal vessel diameter and posterior segment optical coherence tomography variables in middle-aged Caucasians: the Northern Finland Birth Cohort Eye Study |
title_sort |
relation between retinal vessel diameter and posterior segment optical coherence tomography variables in middle-aged caucasians: the northern finland birth cohort eye study |
publisher |
BMJ Publishing Group Ltd |
publishDate |
2020 |
url |
http://bjo.bmj.com/cgi/content/short/104/10/1435 https://doi.org/10.1136/bjophthalmol-2019-314803 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_relation |
http://bjo.bmj.com/cgi/content/short/104/10/1435 http://dx.doi.org/10.1136/bjophthalmol-2019-314803 |
op_rights |
Copyright (C) 2020, BMJ Publishing Group Ltd |
op_doi |
https://doi.org/10.1136/bjophthalmol-2019-314803 |
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British Journal of Ophthalmology |
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104 |
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10 |
container_start_page |
1435 |
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1442 |
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1766144689311842304 |