Estrogen Receptor {alpha} Gene Polymorphisms in Systemic Lupus Erythematosus
Objective: To analyze associations of two estrogen receptor alpha (ERα) gene polymorphisms in 260 patients with SLE from northern Sweden. The two polymorphisms, PvuII T/C and the XbaI A/G, are located in the first intron of the ERa gene. Methods: All patients fulfilling at least four of the ACR crit...
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fthighwire:oai:open-archive.highwire.org:annrheumdis:ard.2004.032425v1 2023-05-15T17:45:00+02:00 Estrogen Receptor {alpha} Gene Polymorphisms in Systemic Lupus Erythematosus Johansson, Martin Ärlestig, Lisbeth Möller, Bozena Smedby, Torgny Rantapää-Dahlqvist, Solbritt 2005-04-07 06:24:34.0 text/html http://ard.bmj.com/cgi/content/short/ard.2004.032425v1 https://doi.org/10.1136/ard.2004.032425 en eng BMJ Publishing Group Ltd http://ard.bmj.com/cgi/content/short/ard.2004.032425v1 http://dx.doi.org/10.1136/ard.2004.032425 Copyright (C) 2005, BMJ Publishing Group Ltd Extended Report TEXT 2005 fthighwire https://doi.org/10.1136/ard.2004.032425 2015-02-28T17:09:00Z Objective: To analyze associations of two estrogen receptor alpha (ERα) gene polymorphisms in 260 patients with SLE from northern Sweden. The two polymorphisms, PvuII T/C and the XbaI A/G, are located in the first intron of the ERa gene. Methods: All patients fulfilling at least four of the ACR criteria for SLE were consecutively recruited during one year. The SLEDAI score and SLICC damage index were recorded. 670 individuals from the same geographical area served as controls. DNA from the patients and controls was extracted and genotyped using the 5' nuclease assay with an ABI PRISM 7900HT instrument. The genotype/phenotype relationships were calculated using SPSS. Results: The unusual PvuII C-allele was associated with malar rashand the unusual XbaI G-allele with photosensitivity (P=0.001, OR=2.53, 95% CI=1.43- 4.47 and P=0.007, OR=2.12, 95% CI=1.22-3.66 respectively). The common XbaI AA-genotype was associated with serositis (P=0.013, OR=1.92, 95% CI=1.15- 3.22). Based on the SLICC damage index associations of the common TT-genotype and AA-genotype with cognitive impairment were identified (P=0.018, OR=2.47, 95% CI=1.17-5.25 and P=0.018, OR=2.75, 95% CI=1.19-6.38 respectively). There was also an association of the XbaI AA genotype with the angina/coronary artery bypass variable (P=0.042, OR=2.58, 95% CI=1.03-6.43). Of the variables describing disease severity and duration it was found that carriers of the unusual PvuII C-allele showed a later onset of SLE (P=0.02) and carriers of the unusual XbaI G-allele a lower SLICC damage index. Conclusion: The unusual PvuII C- and XbaI G- allele were associated with a milder form of SLE characterised by skin manifestations, later onset and less organ damage. Text Northern Sweden HighWire Press (Stanford University) Annals of the Rheumatic Diseases 64 11 1611 1617 |
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Extended Report Johansson, Martin Ärlestig, Lisbeth Möller, Bozena Smedby, Torgny Rantapää-Dahlqvist, Solbritt Estrogen Receptor {alpha} Gene Polymorphisms in Systemic Lupus Erythematosus |
topic_facet |
Extended Report |
description |
Objective: To analyze associations of two estrogen receptor alpha (ERα) gene polymorphisms in 260 patients with SLE from northern Sweden. The two polymorphisms, PvuII T/C and the XbaI A/G, are located in the first intron of the ERa gene. Methods: All patients fulfilling at least four of the ACR criteria for SLE were consecutively recruited during one year. The SLEDAI score and SLICC damage index were recorded. 670 individuals from the same geographical area served as controls. DNA from the patients and controls was extracted and genotyped using the 5' nuclease assay with an ABI PRISM 7900HT instrument. The genotype/phenotype relationships were calculated using SPSS. Results: The unusual PvuII C-allele was associated with malar rashand the unusual XbaI G-allele with photosensitivity (P=0.001, OR=2.53, 95% CI=1.43- 4.47 and P=0.007, OR=2.12, 95% CI=1.22-3.66 respectively). The common XbaI AA-genotype was associated with serositis (P=0.013, OR=1.92, 95% CI=1.15- 3.22). Based on the SLICC damage index associations of the common TT-genotype and AA-genotype with cognitive impairment were identified (P=0.018, OR=2.47, 95% CI=1.17-5.25 and P=0.018, OR=2.75, 95% CI=1.19-6.38 respectively). There was also an association of the XbaI AA genotype with the angina/coronary artery bypass variable (P=0.042, OR=2.58, 95% CI=1.03-6.43). Of the variables describing disease severity and duration it was found that carriers of the unusual PvuII C-allele showed a later onset of SLE (P=0.02) and carriers of the unusual XbaI G-allele a lower SLICC damage index. Conclusion: The unusual PvuII C- and XbaI G- allele were associated with a milder form of SLE characterised by skin manifestations, later onset and less organ damage. |
format |
Text |
author |
Johansson, Martin Ärlestig, Lisbeth Möller, Bozena Smedby, Torgny Rantapää-Dahlqvist, Solbritt |
author_facet |
Johansson, Martin Ärlestig, Lisbeth Möller, Bozena Smedby, Torgny Rantapää-Dahlqvist, Solbritt |
author_sort |
Johansson, Martin |
title |
Estrogen Receptor {alpha} Gene Polymorphisms in Systemic Lupus Erythematosus |
title_short |
Estrogen Receptor {alpha} Gene Polymorphisms in Systemic Lupus Erythematosus |
title_full |
Estrogen Receptor {alpha} Gene Polymorphisms in Systemic Lupus Erythematosus |
title_fullStr |
Estrogen Receptor {alpha} Gene Polymorphisms in Systemic Lupus Erythematosus |
title_full_unstemmed |
Estrogen Receptor {alpha} Gene Polymorphisms in Systemic Lupus Erythematosus |
title_sort |
estrogen receptor {alpha} gene polymorphisms in systemic lupus erythematosus |
publisher |
BMJ Publishing Group Ltd |
publishDate |
2005 |
url |
http://ard.bmj.com/cgi/content/short/ard.2004.032425v1 https://doi.org/10.1136/ard.2004.032425 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_relation |
http://ard.bmj.com/cgi/content/short/ard.2004.032425v1 http://dx.doi.org/10.1136/ard.2004.032425 |
op_rights |
Copyright (C) 2005, BMJ Publishing Group Ltd |
op_doi |
https://doi.org/10.1136/ard.2004.032425 |
container_title |
Annals of the Rheumatic Diseases |
container_volume |
64 |
container_issue |
11 |
container_start_page |
1611 |
op_container_end_page |
1617 |
_version_ |
1766147712788463616 |