Genetic predisposition of the severity of joint destruction in rheumatoid arthritis: a population-based study
Background The susceptibility to rheumatoid arthritis (RA) is partly heritable, but whether the severity of RA is also influenced by genetics has not been determined. The evaluation of the heritability of the severity of RA is basic to further studies on genetic factors. A study was undertaken to de...
Published in: | Annals of the Rheumatic Diseases |
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fthighwire:oai:open-archive.highwire.org:annrheumdis:71/5/707 2023-05-15T16:51:17+02:00 Genetic predisposition of the severity of joint destruction in rheumatoid arthritis: a population-based study Knevel, Rachel Gröndal, Gerður Huizinga, Tom W J Visser, A Willemien Jónsson, Helgi Víkingsson, Arnór Geirsson, Árni Jón Steinsson, Kristján van der Helm-van Mil, Annette H M 2012-05-01 00:00:00.0 text/html http://ard.bmj.com/cgi/content/short/71/5/707 https://doi.org/10.1136/annrheumdis-2011-200627 en eng BMJ Publishing Group Ltd http://ard.bmj.com/cgi/content/short/71/5/707 http://dx.doi.org/10.1136/annrheumdis-2011-200627 Copyright (C) 2012, BMJ Publishing Group Ltd Clinical and epidemiological research TEXT 2012 fthighwire https://doi.org/10.1136/annrheumdis-2011-200627 2015-02-28T23:51:35Z Background The susceptibility to rheumatoid arthritis (RA) is partly heritable, but whether the severity of RA is also influenced by genetics has not been determined. The evaluation of the heritability of the severity of RA is basic to further studies on genetic factors. A study was undertaken to determine whether joint destruction is heritable. Methods Iceland has an unique comprehensive genealogy database covering today's population and stretching back to ≥1000 years ago, as well as genome-wide single nucleotide polymorphism data for a large part of the population. Hand and feet x-rays of 325 Icelandic patients with RA were scored according to the Sharp-van der Heijde method. The degree of relatedness between patients was estimated in two ways: (1) kinship coefficients (KC) on the genealogical data were expressed; and (2) the identical-by-descent (IBD) was estimated applying long-range phasing of the genetic profile of the patients. The degree of relatedness was tested against the similarity in joint destruction rates by linear regression analysis and the heritability of joint destruction was calculated. Results Significant associations between degree of relatedness and similarity in joint destruction rates were observed for both methods of determining relatedness (p KC =0.018, p IBD =0.003). The estimated heritability was 45% using KC and 58% using the estimated IBD data. Conclusions The severity of joint destruction in RA is influenced by genetic factors. Text Iceland HighWire Press (Stanford University) Annals of the Rheumatic Diseases 71 5 707 709 |
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HighWire Press (Stanford University) |
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language |
English |
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Clinical and epidemiological research |
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Clinical and epidemiological research Knevel, Rachel Gröndal, Gerður Huizinga, Tom W J Visser, A Willemien Jónsson, Helgi Víkingsson, Arnór Geirsson, Árni Jón Steinsson, Kristján van der Helm-van Mil, Annette H M Genetic predisposition of the severity of joint destruction in rheumatoid arthritis: a population-based study |
topic_facet |
Clinical and epidemiological research |
description |
Background The susceptibility to rheumatoid arthritis (RA) is partly heritable, but whether the severity of RA is also influenced by genetics has not been determined. The evaluation of the heritability of the severity of RA is basic to further studies on genetic factors. A study was undertaken to determine whether joint destruction is heritable. Methods Iceland has an unique comprehensive genealogy database covering today's population and stretching back to ≥1000 years ago, as well as genome-wide single nucleotide polymorphism data for a large part of the population. Hand and feet x-rays of 325 Icelandic patients with RA were scored according to the Sharp-van der Heijde method. The degree of relatedness between patients was estimated in two ways: (1) kinship coefficients (KC) on the genealogical data were expressed; and (2) the identical-by-descent (IBD) was estimated applying long-range phasing of the genetic profile of the patients. The degree of relatedness was tested against the similarity in joint destruction rates by linear regression analysis and the heritability of joint destruction was calculated. Results Significant associations between degree of relatedness and similarity in joint destruction rates were observed for both methods of determining relatedness (p KC =0.018, p IBD =0.003). The estimated heritability was 45% using KC and 58% using the estimated IBD data. Conclusions The severity of joint destruction in RA is influenced by genetic factors. |
format |
Text |
author |
Knevel, Rachel Gröndal, Gerður Huizinga, Tom W J Visser, A Willemien Jónsson, Helgi Víkingsson, Arnór Geirsson, Árni Jón Steinsson, Kristján van der Helm-van Mil, Annette H M |
author_facet |
Knevel, Rachel Gröndal, Gerður Huizinga, Tom W J Visser, A Willemien Jónsson, Helgi Víkingsson, Arnór Geirsson, Árni Jón Steinsson, Kristján van der Helm-van Mil, Annette H M |
author_sort |
Knevel, Rachel |
title |
Genetic predisposition of the severity of joint destruction in rheumatoid arthritis: a population-based study |
title_short |
Genetic predisposition of the severity of joint destruction in rheumatoid arthritis: a population-based study |
title_full |
Genetic predisposition of the severity of joint destruction in rheumatoid arthritis: a population-based study |
title_fullStr |
Genetic predisposition of the severity of joint destruction in rheumatoid arthritis: a population-based study |
title_full_unstemmed |
Genetic predisposition of the severity of joint destruction in rheumatoid arthritis: a population-based study |
title_sort |
genetic predisposition of the severity of joint destruction in rheumatoid arthritis: a population-based study |
publisher |
BMJ Publishing Group Ltd |
publishDate |
2012 |
url |
http://ard.bmj.com/cgi/content/short/71/5/707 https://doi.org/10.1136/annrheumdis-2011-200627 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://ard.bmj.com/cgi/content/short/71/5/707 http://dx.doi.org/10.1136/annrheumdis-2011-200627 |
op_rights |
Copyright (C) 2012, BMJ Publishing Group Ltd |
op_doi |
https://doi.org/10.1136/annrheumdis-2011-200627 |
container_title |
Annals of the Rheumatic Diseases |
container_volume |
71 |
container_issue |
5 |
container_start_page |
707 |
op_container_end_page |
709 |
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1766041404542287872 |