TNF{alpha} polymorphisms and risk of psoriatic arthritis
Background: Tumour necrosis factor α (TNFα) is a cytokine of critical importance in psoriatic arthritis. Objectives: (1) To examine the association between TNFα promoter gene polymorphisms and psoriatic arthritis in two well characterised Canadian populations with the disease; (2) to carry out a met...
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fthighwire:oai:open-archive.highwire.org:annrheumdis:65/7/919 2023-05-15T17:22:33+02:00 TNF{alpha} polymorphisms and risk of psoriatic arthritis Rahman, P Siannis, F Butt, C Farewell, V Peddle, L Pellett, F Gladman, D 2006-07-01 00:00:00.0 text/html http://ard.bmj.com/cgi/content/short/65/7/919 https://doi.org/10.1136/ard.2005.039164 en eng BMJ Publishing Group Ltd http://ard.bmj.com/cgi/content/short/65/7/919 http://dx.doi.org/10.1136/ard.2005.039164 Copyright (C) 2006, BMJ Publishing Group Ltd Extended reports TEXT 2006 fthighwire https://doi.org/10.1136/ard.2005.039164 2015-02-28T19:54:24Z Background: Tumour necrosis factor α (TNFα) is a cytokine of critical importance in psoriatic arthritis. Objectives: (1) To examine the association between TNFα promoter gene polymorphisms and psoriatic arthritis in two well characterised Canadian populations with the disease; (2) to carry out a meta-analysis of all TNFα association studies in white psoriatic arthritis populations. Methods: DNA samples were genotyped for five TNF variants by time of flight mass spectrometry using the Sequenom platform. All five single nucleotide polymorphisms were in the 5′ flanking region of TNFα gene at the following positions: −1031 (T→C), −863 (C→A), −857 (C→T), −308 (G→A), and −238 (G→A). Primary analyses were based on logistic regression. Summary estimates of disease/genotype relations from several studies were derived from random effects meta-analyses. Results: 237 psoriatic arthritis subjects and 103 controls from Newfoundland and 203 psoriatic arthritis subjects and 101 controls from Toronto were studied. A combined analysis of data from both populations, showed a significant association between disease status and the −238(A) variant (p = 0.01). The meta-analysis estimate for the −238(A) TNFα variant in eight psoriatic arthritis populations was also significant (odds ratio = 2.29 (95% confidence interval, 1.48 to 3.55)). Conclusions: Analysis of TNFα variants in psoriatic arthritis populations shows that the −238 (A) variant is a significant risk factor for this disease. Text Newfoundland HighWire Press (Stanford University) Annals of the Rheumatic Diseases 65 7 919 923 |
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Extended reports Rahman, P Siannis, F Butt, C Farewell, V Peddle, L Pellett, F Gladman, D TNF{alpha} polymorphisms and risk of psoriatic arthritis |
topic_facet |
Extended reports |
description |
Background: Tumour necrosis factor α (TNFα) is a cytokine of critical importance in psoriatic arthritis. Objectives: (1) To examine the association between TNFα promoter gene polymorphisms and psoriatic arthritis in two well characterised Canadian populations with the disease; (2) to carry out a meta-analysis of all TNFα association studies in white psoriatic arthritis populations. Methods: DNA samples were genotyped for five TNF variants by time of flight mass spectrometry using the Sequenom platform. All five single nucleotide polymorphisms were in the 5′ flanking region of TNFα gene at the following positions: −1031 (T→C), −863 (C→A), −857 (C→T), −308 (G→A), and −238 (G→A). Primary analyses were based on logistic regression. Summary estimates of disease/genotype relations from several studies were derived from random effects meta-analyses. Results: 237 psoriatic arthritis subjects and 103 controls from Newfoundland and 203 psoriatic arthritis subjects and 101 controls from Toronto were studied. A combined analysis of data from both populations, showed a significant association between disease status and the −238(A) variant (p = 0.01). The meta-analysis estimate for the −238(A) TNFα variant in eight psoriatic arthritis populations was also significant (odds ratio = 2.29 (95% confidence interval, 1.48 to 3.55)). Conclusions: Analysis of TNFα variants in psoriatic arthritis populations shows that the −238 (A) variant is a significant risk factor for this disease. |
format |
Text |
author |
Rahman, P Siannis, F Butt, C Farewell, V Peddle, L Pellett, F Gladman, D |
author_facet |
Rahman, P Siannis, F Butt, C Farewell, V Peddle, L Pellett, F Gladman, D |
author_sort |
Rahman, P |
title |
TNF{alpha} polymorphisms and risk of psoriatic arthritis |
title_short |
TNF{alpha} polymorphisms and risk of psoriatic arthritis |
title_full |
TNF{alpha} polymorphisms and risk of psoriatic arthritis |
title_fullStr |
TNF{alpha} polymorphisms and risk of psoriatic arthritis |
title_full_unstemmed |
TNF{alpha} polymorphisms and risk of psoriatic arthritis |
title_sort |
tnf{alpha} polymorphisms and risk of psoriatic arthritis |
publisher |
BMJ Publishing Group Ltd |
publishDate |
2006 |
url |
http://ard.bmj.com/cgi/content/short/65/7/919 https://doi.org/10.1136/ard.2005.039164 |
genre |
Newfoundland |
genre_facet |
Newfoundland |
op_relation |
http://ard.bmj.com/cgi/content/short/65/7/919 http://dx.doi.org/10.1136/ard.2005.039164 |
op_rights |
Copyright (C) 2006, BMJ Publishing Group Ltd |
op_doi |
https://doi.org/10.1136/ard.2005.039164 |
container_title |
Annals of the Rheumatic Diseases |
container_volume |
65 |
container_issue |
7 |
container_start_page |
919 |
op_container_end_page |
923 |
_version_ |
1766109271796219904 |