Components of the metabolic syndrome in long-term survivors of testicular cancer
Background: A possible explanation of the excess cardiovascular risk in testicular cancer (TC) survivors is development of metabolic syndrome. The association between metabolic syndrome and TC treatment is examined in long-term survivors. Patients and methods: In a national follow-up study (1998-200...
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fthighwire:oai:open-archive.highwire.org:annonc:mdl372v1 2023-05-15T18:34:42+02:00 Components of the metabolic syndrome in long-term survivors of testicular cancer Haugnes, H. S. Aass, N. Fosså, S. D. Dahl, O. Klepp, O. Wist, E. A. Svartberg, J. Wilsgaard, T. Bremnes, R. M. 2006-10-23 10:28:59.0 text/html http://annonc.oxfordjournals.org/cgi/content/short/mdl372v1 https://doi.org/10.1093/annonc/mdl372 en eng Oxford University Press http://annonc.oxfordjournals.org/cgi/content/short/mdl372v1 http://dx.doi.org/10.1093/annonc/mdl372 Copyright (C) 2006, European Society for Medical Oncology original article TEXT 2006 fthighwire https://doi.org/10.1093/annonc/mdl372 2016-11-16T16:57:42Z Background: A possible explanation of the excess cardiovascular risk in testicular cancer (TC) survivors is development of metabolic syndrome. The association between metabolic syndrome and TC treatment is examined in long-term survivors. Patients and methods: In a national follow-up study (1998-2002), 1463 TC survivors (diagnosed 1980-1994) participated. Patients >60 years were excluded in the present study, leaving 1135 patients eligible. The patients were divided in four treatment groups: surgery ( n = 225); radiotherapy ( n = 446) and two chemotherapy groups: cumulative cisplatin dose (Cis) ≤850 mg ( n = 376) and Cis >850 mg ( n = 88). A control group consisted of 1150 men from the Tromsø Population Study. Metabolic syndrome was defined according to a modified National Cholesterol Education Program definition. Results: Both chemotherapy groups had increased odds for metabolic syndrome compared with the surgery group, highest for the Cis >850 group [odds ratio (OR) 2.8, 95% confidence interval (CI) 1.6-4.7]. Also, the Cis >850 group had increased odds (OR 2.1, 95% CI 1.3-3.4) for metabolic syndrome compared with the control group. The association between metabolic syndrome and the Cis >850 group was strengthened after adjusting for testosterone, smoking, physical activity, education and family status. Conclusion: TC survivors treated with cisplatin-based chemotherapy have an increased risk of developing metabolic syndrome compared with patients treated with other modalities or with controls. Text Tromsø HighWire Press (Stanford University) Tromsø Annals of Oncology 18 2 241 248 |
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original article Haugnes, H. S. Aass, N. Fosså, S. D. Dahl, O. Klepp, O. Wist, E. A. Svartberg, J. Wilsgaard, T. Bremnes, R. M. Components of the metabolic syndrome in long-term survivors of testicular cancer |
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original article |
description |
Background: A possible explanation of the excess cardiovascular risk in testicular cancer (TC) survivors is development of metabolic syndrome. The association between metabolic syndrome and TC treatment is examined in long-term survivors. Patients and methods: In a national follow-up study (1998-2002), 1463 TC survivors (diagnosed 1980-1994) participated. Patients >60 years were excluded in the present study, leaving 1135 patients eligible. The patients were divided in four treatment groups: surgery ( n = 225); radiotherapy ( n = 446) and two chemotherapy groups: cumulative cisplatin dose (Cis) ≤850 mg ( n = 376) and Cis >850 mg ( n = 88). A control group consisted of 1150 men from the Tromsø Population Study. Metabolic syndrome was defined according to a modified National Cholesterol Education Program definition. Results: Both chemotherapy groups had increased odds for metabolic syndrome compared with the surgery group, highest for the Cis >850 group [odds ratio (OR) 2.8, 95% confidence interval (CI) 1.6-4.7]. Also, the Cis >850 group had increased odds (OR 2.1, 95% CI 1.3-3.4) for metabolic syndrome compared with the control group. The association between metabolic syndrome and the Cis >850 group was strengthened after adjusting for testosterone, smoking, physical activity, education and family status. Conclusion: TC survivors treated with cisplatin-based chemotherapy have an increased risk of developing metabolic syndrome compared with patients treated with other modalities or with controls. |
format |
Text |
author |
Haugnes, H. S. Aass, N. Fosså, S. D. Dahl, O. Klepp, O. Wist, E. A. Svartberg, J. Wilsgaard, T. Bremnes, R. M. |
author_facet |
Haugnes, H. S. Aass, N. Fosså, S. D. Dahl, O. Klepp, O. Wist, E. A. Svartberg, J. Wilsgaard, T. Bremnes, R. M. |
author_sort |
Haugnes, H. S. |
title |
Components of the metabolic syndrome in long-term survivors of testicular cancer |
title_short |
Components of the metabolic syndrome in long-term survivors of testicular cancer |
title_full |
Components of the metabolic syndrome in long-term survivors of testicular cancer |
title_fullStr |
Components of the metabolic syndrome in long-term survivors of testicular cancer |
title_full_unstemmed |
Components of the metabolic syndrome in long-term survivors of testicular cancer |
title_sort |
components of the metabolic syndrome in long-term survivors of testicular cancer |
publisher |
Oxford University Press |
publishDate |
2006 |
url |
http://annonc.oxfordjournals.org/cgi/content/short/mdl372v1 https://doi.org/10.1093/annonc/mdl372 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
http://annonc.oxfordjournals.org/cgi/content/short/mdl372v1 http://dx.doi.org/10.1093/annonc/mdl372 |
op_rights |
Copyright (C) 2006, European Society for Medical Oncology |
op_doi |
https://doi.org/10.1093/annonc/mdl372 |
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Annals of Oncology |
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18 |
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2 |
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241 |
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248 |
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1766219582117249024 |