Breast cancer screening case-control study design: impact on breast cancer mortality
Background: Recent case–control studies on the effectiveness of population-based breast cancer screening show differences in the magnitude of breast cancer mortality reduction. We investigated the role played by aspects of the case–control study design on these differences, e.g. the definition of ca...
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fthighwire:oai:open-archive.highwire.org:annonc:22/4/863 2023-05-15T16:50:34+02:00 Breast cancer screening case-control study design: impact on breast cancer mortality Paap, E. Verbeek, A. L. M. Puliti, D. Paci, E. Broeders, M. J. M. 2011-04-01 00:00:00.0 text/html http://annonc.oxfordjournals.org/cgi/content/short/22/4/863 https://doi.org/10.1093/annonc/mdq447 en eng Oxford University Press http://annonc.oxfordjournals.org/cgi/content/short/22/4/863 http://dx.doi.org/10.1093/annonc/mdq447 Copyright (C) 2011, European Society for Medical Oncology breast cancer TEXT 2011 fthighwire https://doi.org/10.1093/annonc/mdq447 2013-05-27T13:59:15Z Background: Recent case–control studies on the effectiveness of population-based breast cancer screening show differences in the magnitude of breast cancer mortality reduction. We investigated the role played by aspects of the case–control study design on these differences, e.g. the definition of cases and exposure to screening. Material and methods: We investigated six case–control studies conducted in East Anglia (UK), Wales, Iceland, central and northern Italy, South Australia and The Netherlands. Results: The breast cancer mortality reduction in the different case–control studies ranged from 38% to 70% in the screened versus the nonscreened women. We identified differences in design, e.g. the inclusion or exclusion of the first years of screening, and the correction factor for self-selection bias. Conclusions: Overall, the design of the case–control studies was similar. The differences in the magnitude of breast cancer mortality reductions are therefore unlikely to be caused by variations in the design of the case–control studies. These differences must be due to other factors, like the organisation of the service screening programme and the attendance rate. The reduction in breast cancer mortality estimated in these case–control studies indicates that the impact of current mammographic screening is at least consistent with the effect reported by the former randomised screening trials. Text Iceland HighWire Press (Stanford University) Annals of Oncology 22 4 863 869 |
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HighWire Press (Stanford University) |
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breast cancer |
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breast cancer Paap, E. Verbeek, A. L. M. Puliti, D. Paci, E. Broeders, M. J. M. Breast cancer screening case-control study design: impact on breast cancer mortality |
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breast cancer |
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Background: Recent case–control studies on the effectiveness of population-based breast cancer screening show differences in the magnitude of breast cancer mortality reduction. We investigated the role played by aspects of the case–control study design on these differences, e.g. the definition of cases and exposure to screening. Material and methods: We investigated six case–control studies conducted in East Anglia (UK), Wales, Iceland, central and northern Italy, South Australia and The Netherlands. Results: The breast cancer mortality reduction in the different case–control studies ranged from 38% to 70% in the screened versus the nonscreened women. We identified differences in design, e.g. the inclusion or exclusion of the first years of screening, and the correction factor for self-selection bias. Conclusions: Overall, the design of the case–control studies was similar. The differences in the magnitude of breast cancer mortality reductions are therefore unlikely to be caused by variations in the design of the case–control studies. These differences must be due to other factors, like the organisation of the service screening programme and the attendance rate. The reduction in breast cancer mortality estimated in these case–control studies indicates that the impact of current mammographic screening is at least consistent with the effect reported by the former randomised screening trials. |
format |
Text |
author |
Paap, E. Verbeek, A. L. M. Puliti, D. Paci, E. Broeders, M. J. M. |
author_facet |
Paap, E. Verbeek, A. L. M. Puliti, D. Paci, E. Broeders, M. J. M. |
author_sort |
Paap, E. |
title |
Breast cancer screening case-control study design: impact on breast cancer mortality |
title_short |
Breast cancer screening case-control study design: impact on breast cancer mortality |
title_full |
Breast cancer screening case-control study design: impact on breast cancer mortality |
title_fullStr |
Breast cancer screening case-control study design: impact on breast cancer mortality |
title_full_unstemmed |
Breast cancer screening case-control study design: impact on breast cancer mortality |
title_sort |
breast cancer screening case-control study design: impact on breast cancer mortality |
publisher |
Oxford University Press |
publishDate |
2011 |
url |
http://annonc.oxfordjournals.org/cgi/content/short/22/4/863 https://doi.org/10.1093/annonc/mdq447 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://annonc.oxfordjournals.org/cgi/content/short/22/4/863 http://dx.doi.org/10.1093/annonc/mdq447 |
op_rights |
Copyright (C) 2011, European Society for Medical Oncology |
op_doi |
https://doi.org/10.1093/annonc/mdq447 |
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Annals of Oncology |
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22 |
container_issue |
4 |
container_start_page |
863 |
op_container_end_page |
869 |
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1766040707342008320 |