Tracking of Serum 25-Hydroxyvitamin D Levels During 14 Years in a Population-based Study and During 12 Months in an Intervention Study
Low serum 25-hydroxyvitamin D (25(OH)D) levels are associated with risk factors for cardiovascular disease, and they also appear to predict later development of type 2 diabetes, cancer, and an increased mortality rate. These predictions are all based on a single 25(OH)D measurement, but so far there...
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fthighwire:oai:open-archive.highwire.org:amjepid:kwq005v1 2023-05-15T18:34:43+02:00 Tracking of Serum 25-Hydroxyvitamin D Levels During 14 Years in a Population-based Study and During 12 Months in an Intervention Study Jorde, Rolf Sneve, Monica Hutchinson, Moira Emaus, Nina Figenschau, Yngve Grimnes, Guri 2010-03-10 01:50:53.0 text/html http://aje.oxfordjournals.org/cgi/content/short/kwq005v1 https://doi.org/10.1093/aje/kwq005 en eng Oxford University Press http://aje.oxfordjournals.org/cgi/content/short/kwq005v1 http://dx.doi.org/10.1093/aje/kwq005 Copyright (C) 2010, Oxford University Press Original Contribution TEXT 2010 fthighwire https://doi.org/10.1093/aje/kwq005 2016-11-16T18:56:54Z Low serum 25-hydroxyvitamin D (25(OH)D) levels are associated with risk factors for cardiovascular disease, and they also appear to predict later development of type 2 diabetes, cancer, and an increased mortality rate. These predictions are all based on a single 25(OH)D measurement, but so far there are no known reports on tracking of serum 25(OH)D levels. In the present Norwegian study, serum 25(OH)D levels were measured 1) in 2,668 subjects in the 1994 and 2008 Tromsø surveys and 2) every third month for 1 year in 94 subjects randomly assigned to placebo in a vitamin D intervention study. There was a marked seasonal variation in 25(OH)D, and, depending on the method of adjusting for season, the correlation coefficient between serum 25(OH)D measurements from 1994 and 2008 ranged from 0.42 to 0.52. In the 1-year intervention study, the correlation between baseline and 12-month values was 0.80. Apart from the effect of season, changes in weight, intake of vitamin D, and physical activity were related to change in serum 25(OH)D levels. Tracking of serum 25(OH)D appears similar to that for blood pressure and serum lipids, and it provides some support for the use of a single 25(OH)D measurement to predict future health outcomes. Text Tromsø HighWire Press (Stanford University) Tromsø American Journal of Epidemiology 171 8 903 908 |
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Original Contribution Jorde, Rolf Sneve, Monica Hutchinson, Moira Emaus, Nina Figenschau, Yngve Grimnes, Guri Tracking of Serum 25-Hydroxyvitamin D Levels During 14 Years in a Population-based Study and During 12 Months in an Intervention Study |
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Original Contribution |
description |
Low serum 25-hydroxyvitamin D (25(OH)D) levels are associated with risk factors for cardiovascular disease, and they also appear to predict later development of type 2 diabetes, cancer, and an increased mortality rate. These predictions are all based on a single 25(OH)D measurement, but so far there are no known reports on tracking of serum 25(OH)D levels. In the present Norwegian study, serum 25(OH)D levels were measured 1) in 2,668 subjects in the 1994 and 2008 Tromsø surveys and 2) every third month for 1 year in 94 subjects randomly assigned to placebo in a vitamin D intervention study. There was a marked seasonal variation in 25(OH)D, and, depending on the method of adjusting for season, the correlation coefficient between serum 25(OH)D measurements from 1994 and 2008 ranged from 0.42 to 0.52. In the 1-year intervention study, the correlation between baseline and 12-month values was 0.80. Apart from the effect of season, changes in weight, intake of vitamin D, and physical activity were related to change in serum 25(OH)D levels. Tracking of serum 25(OH)D appears similar to that for blood pressure and serum lipids, and it provides some support for the use of a single 25(OH)D measurement to predict future health outcomes. |
format |
Text |
author |
Jorde, Rolf Sneve, Monica Hutchinson, Moira Emaus, Nina Figenschau, Yngve Grimnes, Guri |
author_facet |
Jorde, Rolf Sneve, Monica Hutchinson, Moira Emaus, Nina Figenschau, Yngve Grimnes, Guri |
author_sort |
Jorde, Rolf |
title |
Tracking of Serum 25-Hydroxyvitamin D Levels During 14 Years in a Population-based Study and During 12 Months in an Intervention Study |
title_short |
Tracking of Serum 25-Hydroxyvitamin D Levels During 14 Years in a Population-based Study and During 12 Months in an Intervention Study |
title_full |
Tracking of Serum 25-Hydroxyvitamin D Levels During 14 Years in a Population-based Study and During 12 Months in an Intervention Study |
title_fullStr |
Tracking of Serum 25-Hydroxyvitamin D Levels During 14 Years in a Population-based Study and During 12 Months in an Intervention Study |
title_full_unstemmed |
Tracking of Serum 25-Hydroxyvitamin D Levels During 14 Years in a Population-based Study and During 12 Months in an Intervention Study |
title_sort |
tracking of serum 25-hydroxyvitamin d levels during 14 years in a population-based study and during 12 months in an intervention study |
publisher |
Oxford University Press |
publishDate |
2010 |
url |
http://aje.oxfordjournals.org/cgi/content/short/kwq005v1 https://doi.org/10.1093/aje/kwq005 |
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Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
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Tromsø |
op_relation |
http://aje.oxfordjournals.org/cgi/content/short/kwq005v1 http://dx.doi.org/10.1093/aje/kwq005 |
op_rights |
Copyright (C) 2010, Oxford University Press |
op_doi |
https://doi.org/10.1093/aje/kwq005 |
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American Journal of Epidemiology |
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171 |
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8 |
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903 |
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908 |
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1766219597678116864 |