Adolescent Manifestations of Metabolic Syndrome Among Children Born to Women With Gestational Diabetes in a General-Population Birth Cohort
The association between maternal gestational diabetes (GDM) and manifestations of metabolic syndrome among Caucasian adolescents was studied with data from the population-based Northern Finland 1986 Birth Cohort. This is a longitudinal cohort study from early pregnancy until offspring age 16 years a...
Published in: | American Journal of Epidemiology |
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fthighwire:oai:open-archive.highwire.org:amjepid:kwp020v1 2023-05-15T17:42:38+02:00 Adolescent Manifestations of Metabolic Syndrome Among Children Born to Women With Gestational Diabetes in a General-Population Birth Cohort Vääräsmäki, Marja Pouta, Anneli Elliot, Paul Tapanainen, Päivi Sovio, Ulla Ruokonen, Aimo Hartikainen, Anna-Liisa McCarthy, Mark Järvelin, Marjo-Riitta 2009-04-10 06:49:07.0 text/html http://aje.oxfordjournals.org/cgi/content/short/kwp020v1 https://doi.org/10.1093/aje/kwp020 en eng Oxford University Press http://aje.oxfordjournals.org/cgi/content/short/kwp020v1 http://dx.doi.org/10.1093/aje/kwp020 Copyright (C) 2009, Oxford University Press Original Contribution TEXT 2009 fthighwire https://doi.org/10.1093/aje/kwp020 2016-11-16T18:54:43Z The association between maternal gestational diabetes (GDM) and manifestations of metabolic syndrome among Caucasian adolescents was studied with data from the population-based Northern Finland 1986 Birth Cohort. This is a longitudinal cohort study from early pregnancy until offspring age 16 years and includes data from a risk group-based GDM screen of pregnant mothers by an oral glucose tolerance test. Metabolic outcomes were compared between the offspring of women with GDM (OGDM; n = 95) and reference group offspring ( n = 3,909). The prevalence of overweight was significantly higher in the OGDM group (18.8 vs. 8.4%; P < 0.001) than in the reference group. The median body mass index (20.8 vs. 20.2 kg/m2, 95% confidence interval (CI) for the percentage difference adjusted for sex: 3.5%, 9.5%), waist circumference (73.3 vs. 71.5 cm, 95% CI: 3.2%, 7.5%), and fasting insulin (10.20 vs. 9.30 milliunits/L, 95% CI: 5.9%, 26.0%) were higher, and homeostatic model assessment-insulin sensitivity (74.7 vs. 82.3, 95% CI: −20.6%, −5.4%) was lower in the OGDM group. These differences were similar after an additional adjustment for birth weight and gestational age. The differences in waist circumference, insulin, and homeostatic model assessment-insulin sensitivity were attenuated but remained statistically significant after additional adjustment for body mass index at 16 years. These findings highlight the importance of prevention strategies among children born to women with GDM. Text Northern Finland HighWire Press (Stanford University) American Journal of Epidemiology 169 10 1209 1215 |
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Original Contribution |
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Original Contribution Vääräsmäki, Marja Pouta, Anneli Elliot, Paul Tapanainen, Päivi Sovio, Ulla Ruokonen, Aimo Hartikainen, Anna-Liisa McCarthy, Mark Järvelin, Marjo-Riitta Adolescent Manifestations of Metabolic Syndrome Among Children Born to Women With Gestational Diabetes in a General-Population Birth Cohort |
topic_facet |
Original Contribution |
description |
The association between maternal gestational diabetes (GDM) and manifestations of metabolic syndrome among Caucasian adolescents was studied with data from the population-based Northern Finland 1986 Birth Cohort. This is a longitudinal cohort study from early pregnancy until offspring age 16 years and includes data from a risk group-based GDM screen of pregnant mothers by an oral glucose tolerance test. Metabolic outcomes were compared between the offspring of women with GDM (OGDM; n = 95) and reference group offspring ( n = 3,909). The prevalence of overweight was significantly higher in the OGDM group (18.8 vs. 8.4%; P < 0.001) than in the reference group. The median body mass index (20.8 vs. 20.2 kg/m2, 95% confidence interval (CI) for the percentage difference adjusted for sex: 3.5%, 9.5%), waist circumference (73.3 vs. 71.5 cm, 95% CI: 3.2%, 7.5%), and fasting insulin (10.20 vs. 9.30 milliunits/L, 95% CI: 5.9%, 26.0%) were higher, and homeostatic model assessment-insulin sensitivity (74.7 vs. 82.3, 95% CI: −20.6%, −5.4%) was lower in the OGDM group. These differences were similar after an additional adjustment for birth weight and gestational age. The differences in waist circumference, insulin, and homeostatic model assessment-insulin sensitivity were attenuated but remained statistically significant after additional adjustment for body mass index at 16 years. These findings highlight the importance of prevention strategies among children born to women with GDM. |
format |
Text |
author |
Vääräsmäki, Marja Pouta, Anneli Elliot, Paul Tapanainen, Päivi Sovio, Ulla Ruokonen, Aimo Hartikainen, Anna-Liisa McCarthy, Mark Järvelin, Marjo-Riitta |
author_facet |
Vääräsmäki, Marja Pouta, Anneli Elliot, Paul Tapanainen, Päivi Sovio, Ulla Ruokonen, Aimo Hartikainen, Anna-Liisa McCarthy, Mark Järvelin, Marjo-Riitta |
author_sort |
Vääräsmäki, Marja |
title |
Adolescent Manifestations of Metabolic Syndrome Among Children Born to Women With Gestational Diabetes in a General-Population Birth Cohort |
title_short |
Adolescent Manifestations of Metabolic Syndrome Among Children Born to Women With Gestational Diabetes in a General-Population Birth Cohort |
title_full |
Adolescent Manifestations of Metabolic Syndrome Among Children Born to Women With Gestational Diabetes in a General-Population Birth Cohort |
title_fullStr |
Adolescent Manifestations of Metabolic Syndrome Among Children Born to Women With Gestational Diabetes in a General-Population Birth Cohort |
title_full_unstemmed |
Adolescent Manifestations of Metabolic Syndrome Among Children Born to Women With Gestational Diabetes in a General-Population Birth Cohort |
title_sort |
adolescent manifestations of metabolic syndrome among children born to women with gestational diabetes in a general-population birth cohort |
publisher |
Oxford University Press |
publishDate |
2009 |
url |
http://aje.oxfordjournals.org/cgi/content/short/kwp020v1 https://doi.org/10.1093/aje/kwp020 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_relation |
http://aje.oxfordjournals.org/cgi/content/short/kwp020v1 http://dx.doi.org/10.1093/aje/kwp020 |
op_rights |
Copyright (C) 2009, Oxford University Press |
op_doi |
https://doi.org/10.1093/aje/kwp020 |
container_title |
American Journal of Epidemiology |
container_volume |
169 |
container_issue |
10 |
container_start_page |
1209 |
op_container_end_page |
1215 |
_version_ |
1766144525012566016 |