Milk Intake in Early Life and Risk of Advanced Prostate Cancer
The authors investigated whether early-life residency in certain areas of Iceland marked by distinct differences in milk intake was associated with risk of prostate cancer in a population-based cohort of 8,894 men born between 1907 and 1935. Through linkage to cancer and mortality registers, the men...
Published in: | American Journal of Epidemiology |
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Oxford University Press
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fthighwire:oai:open-archive.highwire.org:amjepid:175/2/144 2023-05-15T16:50:36+02:00 Milk Intake in Early Life and Risk of Advanced Prostate Cancer Torfadottir, Johanna E. Steingrimsdottir, Laufey Mucci, Lorelei Aspelund, Thor Kasperzyk, Julie L. Olafsson, Orn Fall, Katja Tryggvadottir, Laufey Harris, Tamara B. Launer, Lenore Jonsson, Eirikur Tulinius, Hrafn Stampfer, Meir Adami, Hans-Olov Gudnason, Vilmundur Valdimarsdottir, Unnur A. 2012-01-15 00:00:00.0 text/html http://aje.oxfordjournals.org/cgi/content/short/175/2/144 https://doi.org/10.1093/aje/kwr289 en eng Oxford University Press http://aje.oxfordjournals.org/cgi/content/short/175/2/144 http://dx.doi.org/10.1093/aje/kwr289 Copyright (C) 2012, Oxford University Press RESEARCH-ARTICLE TEXT 2012 fthighwire https://doi.org/10.1093/aje/kwr289 2012-02-04T18:53:55Z The authors investigated whether early-life residency in certain areas of Iceland marked by distinct differences in milk intake was associated with risk of prostate cancer in a population-based cohort of 8,894 men born between 1907 and 1935. Through linkage to cancer and mortality registers, the men were followed for prostate cancer diagnosis and mortality from study entry (in waves from 1967 to 1987) through 2009. In 2002–2006, a subgroup of 2,268 participants reported their milk intake in early, mid-, and current life. During a mean follow-up period of 24.3 years, 1,123 men were diagnosed with prostate cancer, including 371 with advanced disease (stage 3 or higher or prostate cancer death). Compared with early-life residency in the capital area, rural residency in the first 20 years of life was marginally associated with increased risk of advanced prostate cancer (hazard ratio = 1.29, 95% confidence interval (CI): 0.97, 1.73), particularly among men born before 1920 (hazard ratio = 1.64, 95% CI: 1.06, 2.56). Daily milk consumption in adolescence (vs. less than daily), but not in midlife or currently, was associated with a 3.2-fold risk of advanced prostate cancer (95% CI: 1.25, 8.28). These data suggest that frequent milk intake in adolescence increases risk of advanced prostate cancer. Text Iceland HighWire Press (Stanford University) American Journal of Epidemiology 175 2 144 153 |
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RESEARCH-ARTICLE Torfadottir, Johanna E. Steingrimsdottir, Laufey Mucci, Lorelei Aspelund, Thor Kasperzyk, Julie L. Olafsson, Orn Fall, Katja Tryggvadottir, Laufey Harris, Tamara B. Launer, Lenore Jonsson, Eirikur Tulinius, Hrafn Stampfer, Meir Adami, Hans-Olov Gudnason, Vilmundur Valdimarsdottir, Unnur A. Milk Intake in Early Life and Risk of Advanced Prostate Cancer |
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RESEARCH-ARTICLE |
description |
The authors investigated whether early-life residency in certain areas of Iceland marked by distinct differences in milk intake was associated with risk of prostate cancer in a population-based cohort of 8,894 men born between 1907 and 1935. Through linkage to cancer and mortality registers, the men were followed for prostate cancer diagnosis and mortality from study entry (in waves from 1967 to 1987) through 2009. In 2002–2006, a subgroup of 2,268 participants reported their milk intake in early, mid-, and current life. During a mean follow-up period of 24.3 years, 1,123 men were diagnosed with prostate cancer, including 371 with advanced disease (stage 3 or higher or prostate cancer death). Compared with early-life residency in the capital area, rural residency in the first 20 years of life was marginally associated with increased risk of advanced prostate cancer (hazard ratio = 1.29, 95% confidence interval (CI): 0.97, 1.73), particularly among men born before 1920 (hazard ratio = 1.64, 95% CI: 1.06, 2.56). Daily milk consumption in adolescence (vs. less than daily), but not in midlife or currently, was associated with a 3.2-fold risk of advanced prostate cancer (95% CI: 1.25, 8.28). These data suggest that frequent milk intake in adolescence increases risk of advanced prostate cancer. |
format |
Text |
author |
Torfadottir, Johanna E. Steingrimsdottir, Laufey Mucci, Lorelei Aspelund, Thor Kasperzyk, Julie L. Olafsson, Orn Fall, Katja Tryggvadottir, Laufey Harris, Tamara B. Launer, Lenore Jonsson, Eirikur Tulinius, Hrafn Stampfer, Meir Adami, Hans-Olov Gudnason, Vilmundur Valdimarsdottir, Unnur A. |
author_facet |
Torfadottir, Johanna E. Steingrimsdottir, Laufey Mucci, Lorelei Aspelund, Thor Kasperzyk, Julie L. Olafsson, Orn Fall, Katja Tryggvadottir, Laufey Harris, Tamara B. Launer, Lenore Jonsson, Eirikur Tulinius, Hrafn Stampfer, Meir Adami, Hans-Olov Gudnason, Vilmundur Valdimarsdottir, Unnur A. |
author_sort |
Torfadottir, Johanna E. |
title |
Milk Intake in Early Life and Risk of Advanced Prostate Cancer |
title_short |
Milk Intake in Early Life and Risk of Advanced Prostate Cancer |
title_full |
Milk Intake in Early Life and Risk of Advanced Prostate Cancer |
title_fullStr |
Milk Intake in Early Life and Risk of Advanced Prostate Cancer |
title_full_unstemmed |
Milk Intake in Early Life and Risk of Advanced Prostate Cancer |
title_sort |
milk intake in early life and risk of advanced prostate cancer |
publisher |
Oxford University Press |
publishDate |
2012 |
url |
http://aje.oxfordjournals.org/cgi/content/short/175/2/144 https://doi.org/10.1093/aje/kwr289 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://aje.oxfordjournals.org/cgi/content/short/175/2/144 http://dx.doi.org/10.1093/aje/kwr289 |
op_rights |
Copyright (C) 2012, Oxford University Press |
op_doi |
https://doi.org/10.1093/aje/kwr289 |
container_title |
American Journal of Epidemiology |
container_volume |
175 |
container_issue |
2 |
container_start_page |
144 |
op_container_end_page |
153 |
_version_ |
1766040739128541184 |