Human Chorionic Gonadotropin and Alpha-Fetoprotein Concentrations in Pregnancy and Maternal Risk of Breast Cancer: A Nested Case-Control Study
Pregnancy hormones are believed to be involved in the protection against breast cancer conferred by pregnancy. The authors explored the association of maternal breast cancer with human chorionic gonadotropin (hCG) and α-fetoprotein (AFP). In 2001, a case-control study was nested within the Northern...
Published in: | American Journal of Epidemiology |
---|---|
Main Authors: | , , , , , , , , , , , , , |
Format: | Text |
Language: | English |
Published: |
Oxford University Press
2008
|
Subjects: | |
Online Access: | http://aje.oxfordjournals.org/cgi/content/short/168/11/1284 https://doi.org/10.1093/aje/kwn254 |
id |
fthighwire:oai:open-archive.highwire.org:amjepid:168/11/1284 |
---|---|
record_format |
openpolar |
spelling |
fthighwire:oai:open-archive.highwire.org:amjepid:168/11/1284 2023-05-15T17:44:47+02:00 Human Chorionic Gonadotropin and Alpha-Fetoprotein Concentrations in Pregnancy and Maternal Risk of Breast Cancer: A Nested Case-Control Study Lukanova, Annekatrin Andersson, Ritu Wulff, Marianne Zeleniuch-Jacquotte, Anne Grankvist, Kjell Dossus, Laure Afanasyeva, Yelena Johansson, Robert Arslan, Alan A. Lenner, Per Wadell, Göran Hallmans, Göran Toniolo, Paolo Lundin, Eva 2008-12-01 00:00:00.0 text/html http://aje.oxfordjournals.org/cgi/content/short/168/11/1284 https://doi.org/10.1093/aje/kwn254 en eng Oxford University Press http://aje.oxfordjournals.org/cgi/content/short/168/11/1284 http://dx.doi.org/10.1093/aje/kwn254 Copyright (C) 2008, Oxford University Press RESEARCH-ARTICLE TEXT 2008 fthighwire https://doi.org/10.1093/aje/kwn254 2016-11-16T18:47:21Z Pregnancy hormones are believed to be involved in the protection against breast cancer conferred by pregnancy. The authors explored the association of maternal breast cancer with human chorionic gonadotropin (hCG) and α-fetoprotein (AFP). In 2001, a case-control study was nested within the Northern Sweden Maternity Cohort, an ongoing study in which blood samples have been collected from first-trimester pregnant women since 1975. Cases ( n = 210) and controls ( n = 357) were matched for age, parity, and date of blood donation. Concentrations of hCG and AFP were measured by immunoassay. No overall significant association of breast cancer with either hCG or AFP was observed. However, women with hCG levels in the top tertile tended to be at lower risk of breast cancer than women with hCG levels in the lowest tertile in the whole study population and in subgroups of age at sampling, parity, and age at cancer diagnosis. A borderline-significant decrease in risk with high hCG levels was observed in women who developed breast cancer after the median lag time to cancer diagnosis (≥14 years; odds ratio = 0.53, 95% confidence interval: 0.27, 1.03; P = 0.06). These findings, though very preliminary, are consistent with a possible long-term protective association of breast cancer risk with elevated levels of circulating hCG in the early stages of pregnancy. Text Northern Sweden HighWire Press (Stanford University) American Journal of Epidemiology 168 11 1284 1291 |
institution |
Open Polar |
collection |
HighWire Press (Stanford University) |
op_collection_id |
fthighwire |
language |
English |
topic |
RESEARCH-ARTICLE |
spellingShingle |
RESEARCH-ARTICLE Lukanova, Annekatrin Andersson, Ritu Wulff, Marianne Zeleniuch-Jacquotte, Anne Grankvist, Kjell Dossus, Laure Afanasyeva, Yelena Johansson, Robert Arslan, Alan A. Lenner, Per Wadell, Göran Hallmans, Göran Toniolo, Paolo Lundin, Eva Human Chorionic Gonadotropin and Alpha-Fetoprotein Concentrations in Pregnancy and Maternal Risk of Breast Cancer: A Nested Case-Control Study |
topic_facet |
RESEARCH-ARTICLE |
description |
Pregnancy hormones are believed to be involved in the protection against breast cancer conferred by pregnancy. The authors explored the association of maternal breast cancer with human chorionic gonadotropin (hCG) and α-fetoprotein (AFP). In 2001, a case-control study was nested within the Northern Sweden Maternity Cohort, an ongoing study in which blood samples have been collected from first-trimester pregnant women since 1975. Cases ( n = 210) and controls ( n = 357) were matched for age, parity, and date of blood donation. Concentrations of hCG and AFP were measured by immunoassay. No overall significant association of breast cancer with either hCG or AFP was observed. However, women with hCG levels in the top tertile tended to be at lower risk of breast cancer than women with hCG levels in the lowest tertile in the whole study population and in subgroups of age at sampling, parity, and age at cancer diagnosis. A borderline-significant decrease in risk with high hCG levels was observed in women who developed breast cancer after the median lag time to cancer diagnosis (≥14 years; odds ratio = 0.53, 95% confidence interval: 0.27, 1.03; P = 0.06). These findings, though very preliminary, are consistent with a possible long-term protective association of breast cancer risk with elevated levels of circulating hCG in the early stages of pregnancy. |
format |
Text |
author |
Lukanova, Annekatrin Andersson, Ritu Wulff, Marianne Zeleniuch-Jacquotte, Anne Grankvist, Kjell Dossus, Laure Afanasyeva, Yelena Johansson, Robert Arslan, Alan A. Lenner, Per Wadell, Göran Hallmans, Göran Toniolo, Paolo Lundin, Eva |
author_facet |
Lukanova, Annekatrin Andersson, Ritu Wulff, Marianne Zeleniuch-Jacquotte, Anne Grankvist, Kjell Dossus, Laure Afanasyeva, Yelena Johansson, Robert Arslan, Alan A. Lenner, Per Wadell, Göran Hallmans, Göran Toniolo, Paolo Lundin, Eva |
author_sort |
Lukanova, Annekatrin |
title |
Human Chorionic Gonadotropin and Alpha-Fetoprotein Concentrations in Pregnancy and Maternal Risk of Breast Cancer: A Nested Case-Control Study |
title_short |
Human Chorionic Gonadotropin and Alpha-Fetoprotein Concentrations in Pregnancy and Maternal Risk of Breast Cancer: A Nested Case-Control Study |
title_full |
Human Chorionic Gonadotropin and Alpha-Fetoprotein Concentrations in Pregnancy and Maternal Risk of Breast Cancer: A Nested Case-Control Study |
title_fullStr |
Human Chorionic Gonadotropin and Alpha-Fetoprotein Concentrations in Pregnancy and Maternal Risk of Breast Cancer: A Nested Case-Control Study |
title_full_unstemmed |
Human Chorionic Gonadotropin and Alpha-Fetoprotein Concentrations in Pregnancy and Maternal Risk of Breast Cancer: A Nested Case-Control Study |
title_sort |
human chorionic gonadotropin and alpha-fetoprotein concentrations in pregnancy and maternal risk of breast cancer: a nested case-control study |
publisher |
Oxford University Press |
publishDate |
2008 |
url |
http://aje.oxfordjournals.org/cgi/content/short/168/11/1284 https://doi.org/10.1093/aje/kwn254 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_relation |
http://aje.oxfordjournals.org/cgi/content/short/168/11/1284 http://dx.doi.org/10.1093/aje/kwn254 |
op_rights |
Copyright (C) 2008, Oxford University Press |
op_doi |
https://doi.org/10.1093/aje/kwn254 |
container_title |
American Journal of Epidemiology |
container_volume |
168 |
container_issue |
11 |
container_start_page |
1284 |
op_container_end_page |
1291 |
_version_ |
1766147073309147136 |