Variations in Prenatal Sociodemographic Factors associated with Intellectual Disability: A Study of the 20-Year Interval between Two Birth Cohorts in Northern Finland
The authors followed two cohorts of children born in northern Finland in 1966 ( n = 12,058) and 1985–1986 ( n = 9,432) to examine whether associations between maternal sociodemographic factors assessed during pregnancy and intellectual disability in the offspring changed over a 20-year interval. Bot...
Published in: | American Journal of Epidemiology |
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fthighwire:oai:open-archive.highwire.org:amjepid:167/2/169 2023-05-15T17:42:17+02:00 Variations in Prenatal Sociodemographic Factors associated with Intellectual Disability: A Study of the 20-Year Interval between Two Birth Cohorts in Northern Finland Heikura, Ulla Taanila, Anja Hartikainen, Anna-Liisa Olsen, Päivi Linna, Sirkka-Liisa Wendt, Lennart von Järvelin, Marjo-Riitta 2008-01-15 00:00:00.0 text/html http://aje.oxfordjournals.org/cgi/content/short/167/2/169 https://doi.org/10.1093/aje/kwm291 en eng Oxford University Press http://aje.oxfordjournals.org/cgi/content/short/167/2/169 http://dx.doi.org/10.1093/aje/kwm291 Copyright (C) 2008, Oxford University Press RESEARCH-ARTICLE TEXT 2008 fthighwire https://doi.org/10.1093/aje/kwm291 2008-05-01T04:49:22Z The authors followed two cohorts of children born in northern Finland in 1966 ( n = 12,058) and 1985–1986 ( n = 9,432) to examine whether associations between maternal sociodemographic factors assessed during pregnancy and intellectual disability in the offspring changed over a 20-year interval. Both of the cohorts were followed up to the age of 11.5 years using similar methods and definitions of intellectual disability. Data on sociodemographic factors were based on comparable questionnaires returned by the mothers during the 25th week of gestation. Despite an interval of 20 years between the cohorts, the main indicators of socioeconomic disadvantage and maternal multiparity remained as having the largest impact on the incidence of intellectual disability, while single factors such as older maternal age at delivery, being single, and living in a remote area lost their association with intellectual disability. Over 20 years, prepregnancy maternal obesity (body mass index ≥30) became a newly associated factor (adjusted odds ratio = 2.8, 95% confidence interval: 1.5, 5.3). A future challenge is to explore the mediating mechanisms between intellectual disability and its associated preventable intergenerational environmental or lifestyle factors. Text Northern Finland HighWire Press (Stanford University) American Journal of Epidemiology 167 2 169 177 |
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RESEARCH-ARTICLE Heikura, Ulla Taanila, Anja Hartikainen, Anna-Liisa Olsen, Päivi Linna, Sirkka-Liisa Wendt, Lennart von Järvelin, Marjo-Riitta Variations in Prenatal Sociodemographic Factors associated with Intellectual Disability: A Study of the 20-Year Interval between Two Birth Cohorts in Northern Finland |
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RESEARCH-ARTICLE |
description |
The authors followed two cohorts of children born in northern Finland in 1966 ( n = 12,058) and 1985–1986 ( n = 9,432) to examine whether associations between maternal sociodemographic factors assessed during pregnancy and intellectual disability in the offspring changed over a 20-year interval. Both of the cohorts were followed up to the age of 11.5 years using similar methods and definitions of intellectual disability. Data on sociodemographic factors were based on comparable questionnaires returned by the mothers during the 25th week of gestation. Despite an interval of 20 years between the cohorts, the main indicators of socioeconomic disadvantage and maternal multiparity remained as having the largest impact on the incidence of intellectual disability, while single factors such as older maternal age at delivery, being single, and living in a remote area lost their association with intellectual disability. Over 20 years, prepregnancy maternal obesity (body mass index ≥30) became a newly associated factor (adjusted odds ratio = 2.8, 95% confidence interval: 1.5, 5.3). A future challenge is to explore the mediating mechanisms between intellectual disability and its associated preventable intergenerational environmental or lifestyle factors. |
format |
Text |
author |
Heikura, Ulla Taanila, Anja Hartikainen, Anna-Liisa Olsen, Päivi Linna, Sirkka-Liisa Wendt, Lennart von Järvelin, Marjo-Riitta |
author_facet |
Heikura, Ulla Taanila, Anja Hartikainen, Anna-Liisa Olsen, Päivi Linna, Sirkka-Liisa Wendt, Lennart von Järvelin, Marjo-Riitta |
author_sort |
Heikura, Ulla |
title |
Variations in Prenatal Sociodemographic Factors associated with Intellectual Disability: A Study of the 20-Year Interval between Two Birth Cohorts in Northern Finland |
title_short |
Variations in Prenatal Sociodemographic Factors associated with Intellectual Disability: A Study of the 20-Year Interval between Two Birth Cohorts in Northern Finland |
title_full |
Variations in Prenatal Sociodemographic Factors associated with Intellectual Disability: A Study of the 20-Year Interval between Two Birth Cohorts in Northern Finland |
title_fullStr |
Variations in Prenatal Sociodemographic Factors associated with Intellectual Disability: A Study of the 20-Year Interval between Two Birth Cohorts in Northern Finland |
title_full_unstemmed |
Variations in Prenatal Sociodemographic Factors associated with Intellectual Disability: A Study of the 20-Year Interval between Two Birth Cohorts in Northern Finland |
title_sort |
variations in prenatal sociodemographic factors associated with intellectual disability: a study of the 20-year interval between two birth cohorts in northern finland |
publisher |
Oxford University Press |
publishDate |
2008 |
url |
http://aje.oxfordjournals.org/cgi/content/short/167/2/169 https://doi.org/10.1093/aje/kwm291 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_relation |
http://aje.oxfordjournals.org/cgi/content/short/167/2/169 http://dx.doi.org/10.1093/aje/kwm291 |
op_rights |
Copyright (C) 2008, Oxford University Press |
op_doi |
https://doi.org/10.1093/aje/kwm291 |
container_title |
American Journal of Epidemiology |
container_volume |
167 |
container_issue |
2 |
container_start_page |
169 |
op_container_end_page |
177 |
_version_ |
1766144117214019584 |