Associations between Three Types of Maternal Bacterial Infection and Risk of Leukemia in the Offspring
A case-control study was nested within two maternity cohorts with a total of 7 million years of follow-up for assessment of the role of bacterial infections in childhood leukemia. Offspring of 550,000 mothers in Finland and Iceland were combined to form a joint cohort that was followed for cancer up...
Published in: | American Journal of Epidemiology |
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fthighwire:oai:open-archive.highwire.org:amjepid:162/7/662 2023-05-15T16:47:02+02:00 Associations between Three Types of Maternal Bacterial Infection and Risk of Leukemia in the Offspring Lehtinen, Matti Ögmundsdottir, Helga M. Bloigu, Aini Hakulinen, Timo Hemminki, Elina Gudnadottir, Margret Kjartansdottir, Anne Paavonen, Jorma Pukkala, Eero Tulinius, Hrafn Lehtinen, Tuula Koskela, Pentti 2005-10-01 00:00:00.0 text/html http://aje.oxfordjournals.org/cgi/content/short/162/7/662 https://doi.org/10.1093/aje/kwi261 en eng Oxford University Press http://aje.oxfordjournals.org/cgi/content/short/162/7/662 http://dx.doi.org/10.1093/aje/kwi261 Copyright (C) 2005, Oxford University Press ORIGINAL CONTRIBUTIONS TEXT 2005 fthighwire https://doi.org/10.1093/aje/kwi261 2007-06-24T12:04:05Z A case-control study was nested within two maternity cohorts with a total of 7 million years of follow-up for assessment of the role of bacterial infections in childhood leukemia. Offspring of 550,000 mothers in Finland and Iceland were combined to form a joint cohort that was followed for cancer up to age 15 years during 1975–1997 through national cancer registries. For each index mother-case pair, three or four matched control mother-control pairs were identified from population registers. First-trimester serum samples were retrieved from mothers of 341 acute lymphoblastic leukemia cases and 61 other leukemia cases and from 1,212 control mothers. Sera were tested for antibodies to the genus Chlamydia , Helicobacter pylori , and Mycoplasma pneumoniae . Odds ratios and 95% confidence intervals, adjusted for sibship size, were calculated as estimates of relative risk. M. pneumoniae immunoglobulin M appeared to be associated with increased risk (odds ratio (OR) = 1.6), but the association lost statistical significance when the specificity of the immunoglobulin M was considered (OR = 1.5, 95% confidence interval: 0.9, 2.4). In Iceland, H. pylori immunoglobulin G was associated with increased risk of childhood leukemia in offspring (OR = 2.8, 95% confidence interval: 1.1, 6.9). Since H. pylori immunoglobulin G indicates chronic carriage of the microorganism, early colonization of the offspring probably differs between Iceland and Finland, two affluent countries. Text Iceland HighWire Press (Stanford University) American Journal of Epidemiology 162 7 662 667 |
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HighWire Press (Stanford University) |
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English |
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ORIGINAL CONTRIBUTIONS |
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ORIGINAL CONTRIBUTIONS Lehtinen, Matti Ögmundsdottir, Helga M. Bloigu, Aini Hakulinen, Timo Hemminki, Elina Gudnadottir, Margret Kjartansdottir, Anne Paavonen, Jorma Pukkala, Eero Tulinius, Hrafn Lehtinen, Tuula Koskela, Pentti Associations between Three Types of Maternal Bacterial Infection and Risk of Leukemia in the Offspring |
topic_facet |
ORIGINAL CONTRIBUTIONS |
description |
A case-control study was nested within two maternity cohorts with a total of 7 million years of follow-up for assessment of the role of bacterial infections in childhood leukemia. Offspring of 550,000 mothers in Finland and Iceland were combined to form a joint cohort that was followed for cancer up to age 15 years during 1975–1997 through national cancer registries. For each index mother-case pair, three or four matched control mother-control pairs were identified from population registers. First-trimester serum samples were retrieved from mothers of 341 acute lymphoblastic leukemia cases and 61 other leukemia cases and from 1,212 control mothers. Sera were tested for antibodies to the genus Chlamydia , Helicobacter pylori , and Mycoplasma pneumoniae . Odds ratios and 95% confidence intervals, adjusted for sibship size, were calculated as estimates of relative risk. M. pneumoniae immunoglobulin M appeared to be associated with increased risk (odds ratio (OR) = 1.6), but the association lost statistical significance when the specificity of the immunoglobulin M was considered (OR = 1.5, 95% confidence interval: 0.9, 2.4). In Iceland, H. pylori immunoglobulin G was associated with increased risk of childhood leukemia in offspring (OR = 2.8, 95% confidence interval: 1.1, 6.9). Since H. pylori immunoglobulin G indicates chronic carriage of the microorganism, early colonization of the offspring probably differs between Iceland and Finland, two affluent countries. |
format |
Text |
author |
Lehtinen, Matti Ögmundsdottir, Helga M. Bloigu, Aini Hakulinen, Timo Hemminki, Elina Gudnadottir, Margret Kjartansdottir, Anne Paavonen, Jorma Pukkala, Eero Tulinius, Hrafn Lehtinen, Tuula Koskela, Pentti |
author_facet |
Lehtinen, Matti Ögmundsdottir, Helga M. Bloigu, Aini Hakulinen, Timo Hemminki, Elina Gudnadottir, Margret Kjartansdottir, Anne Paavonen, Jorma Pukkala, Eero Tulinius, Hrafn Lehtinen, Tuula Koskela, Pentti |
author_sort |
Lehtinen, Matti |
title |
Associations between Three Types of Maternal Bacterial Infection and Risk of Leukemia in the Offspring |
title_short |
Associations between Three Types of Maternal Bacterial Infection and Risk of Leukemia in the Offspring |
title_full |
Associations between Three Types of Maternal Bacterial Infection and Risk of Leukemia in the Offspring |
title_fullStr |
Associations between Three Types of Maternal Bacterial Infection and Risk of Leukemia in the Offspring |
title_full_unstemmed |
Associations between Three Types of Maternal Bacterial Infection and Risk of Leukemia in the Offspring |
title_sort |
associations between three types of maternal bacterial infection and risk of leukemia in the offspring |
publisher |
Oxford University Press |
publishDate |
2005 |
url |
http://aje.oxfordjournals.org/cgi/content/short/162/7/662 https://doi.org/10.1093/aje/kwi261 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://aje.oxfordjournals.org/cgi/content/short/162/7/662 http://dx.doi.org/10.1093/aje/kwi261 |
op_rights |
Copyright (C) 2005, Oxford University Press |
op_doi |
https://doi.org/10.1093/aje/kwi261 |
container_title |
American Journal of Epidemiology |
container_volume |
162 |
container_issue |
7 |
container_start_page |
662 |
op_container_end_page |
667 |
_version_ |
1766037140916928512 |