Acute Mountain Sickness Symptom Severity at the South Pole: The Influence of Self-Selected Prophylaxis with Acetazolamide.
INTRODUCTION: Acetazolamide, a carbonic anhydrase inhibitor, remains the only FDA approved pharmaceutical prophylaxis for acute mountain sickness (AMS) though its effectiveness after rapid transport in real world conditions is less clear. METHODS: Over 2 years, 248 healthy adults traveled by airplan...
Main Authors: | , , , , , |
---|---|
Format: | Text |
Language: | unknown |
Published: |
Henry Ford Health Scholarly Commons
2016
|
Subjects: | |
Online Access: | https://scholarlycommons.henryford.com/emergencymedicine_articles/101 https://scholarlycommons.henryford.com/cgi/viewcontent.cgi?article=1103&context=emergencymedicine_articles |
id |
fthenryfordhs:oai:scholarlycommons.henryford.com:emergencymedicine_articles-1103 |
---|---|
record_format |
openpolar |
spelling |
fthenryfordhs:oai:scholarlycommons.henryford.com:emergencymedicine_articles-1103 2023-05-15T18:22:14+02:00 Acute Mountain Sickness Symptom Severity at the South Pole: The Influence of Self-Selected Prophylaxis with Acetazolamide. Harrison, Michael F Anderson, Paul J Johnson, Jacob B Richert, Maile Miller, Andrew D Johnson, Bruce D 2016-01-01T08:00:00Z application/pdf https://scholarlycommons.henryford.com/emergencymedicine_articles/101 https://scholarlycommons.henryford.com/cgi/viewcontent.cgi?article=1103&context=emergencymedicine_articles unknown Henry Ford Health Scholarly Commons https://scholarlycommons.henryford.com/emergencymedicine_articles/101 https://scholarlycommons.henryford.com/cgi/viewcontent.cgi?article=1103&context=emergencymedicine_articles Emergency Medicine Articles Acetazolamide Acute Disease Adult Altitude Sickness Carbonic Anhydrase Inhibitors Female Healthy Volunteers Humans Male Oxygen Plasma Volume Transportation Urinalysis text 2016 fthenryfordhs 2022-05-21T17:20:59Z INTRODUCTION: Acetazolamide, a carbonic anhydrase inhibitor, remains the only FDA approved pharmaceutical prophylaxis for acute mountain sickness (AMS) though its effectiveness after rapid transport in real world conditions is less clear. METHODS: Over 2 years, 248 healthy adults traveled by airplane from sea level (SL) to the South Pole (ALT, ~3200m) and 226 participants provided Lake Louise Symptom Scores (LLSS) on a daily basis for 1 week; vital signs, blood samples, and urine samples were collected at SL and at ALT. Acetazolamide was available to any participant desiring prophylaxis. Comparisons were made between the acetazolamide with AMS (ACZ/AMS) (n = 42), acetazolamide without AMS (ACZ/No AMS)(n = 49), no acetazolamide with AMS (No ACZ/AMS) (n = 56), and the no acetazolamide without AMS (No ACZ/No AMS) (n = 79) groups. Statistical analysis included Chi-squared and one-way ANOVA with Bonferroni post-hoc tests. Significance was p≤0.05. RESULTS: No significant differences were found for between-group characteristics or incidence of AMS between ACZ and No ACZ groups. ACZ/AMS reported greater LLSS, BMI, and red cell distribution width. ACZ/No AMS had the highest oxygen saturation (O2Sat) at ALT. No significant differences were found in serum electrolyte concentrations or PFT results. DISCUSSION: Acetazolamide during rapid ascent provided no apparent protection from AMS based on LLSS. However, it is unclear if this lack of effect was directly associated with the drug or if perhaps there was some selection bias with individuals taking ACZ more likely to have symptoms or if there may have been more of perceptual phenomenon related to a constellation of side effects. Text South pole Henry Ford Health System Scholarly Commons South Pole |
institution |
Open Polar |
collection |
Henry Ford Health System Scholarly Commons |
op_collection_id |
fthenryfordhs |
language |
unknown |
topic |
Acetazolamide Acute Disease Adult Altitude Sickness Carbonic Anhydrase Inhibitors Female Healthy Volunteers Humans Male Oxygen Plasma Volume Transportation Urinalysis |
spellingShingle |
Acetazolamide Acute Disease Adult Altitude Sickness Carbonic Anhydrase Inhibitors Female Healthy Volunteers Humans Male Oxygen Plasma Volume Transportation Urinalysis Harrison, Michael F Anderson, Paul J Johnson, Jacob B Richert, Maile Miller, Andrew D Johnson, Bruce D Acute Mountain Sickness Symptom Severity at the South Pole: The Influence of Self-Selected Prophylaxis with Acetazolamide. |
topic_facet |
Acetazolamide Acute Disease Adult Altitude Sickness Carbonic Anhydrase Inhibitors Female Healthy Volunteers Humans Male Oxygen Plasma Volume Transportation Urinalysis |
description |
INTRODUCTION: Acetazolamide, a carbonic anhydrase inhibitor, remains the only FDA approved pharmaceutical prophylaxis for acute mountain sickness (AMS) though its effectiveness after rapid transport in real world conditions is less clear. METHODS: Over 2 years, 248 healthy adults traveled by airplane from sea level (SL) to the South Pole (ALT, ~3200m) and 226 participants provided Lake Louise Symptom Scores (LLSS) on a daily basis for 1 week; vital signs, blood samples, and urine samples were collected at SL and at ALT. Acetazolamide was available to any participant desiring prophylaxis. Comparisons were made between the acetazolamide with AMS (ACZ/AMS) (n = 42), acetazolamide without AMS (ACZ/No AMS)(n = 49), no acetazolamide with AMS (No ACZ/AMS) (n = 56), and the no acetazolamide without AMS (No ACZ/No AMS) (n = 79) groups. Statistical analysis included Chi-squared and one-way ANOVA with Bonferroni post-hoc tests. Significance was p≤0.05. RESULTS: No significant differences were found for between-group characteristics or incidence of AMS between ACZ and No ACZ groups. ACZ/AMS reported greater LLSS, BMI, and red cell distribution width. ACZ/No AMS had the highest oxygen saturation (O2Sat) at ALT. No significant differences were found in serum electrolyte concentrations or PFT results. DISCUSSION: Acetazolamide during rapid ascent provided no apparent protection from AMS based on LLSS. However, it is unclear if this lack of effect was directly associated with the drug or if perhaps there was some selection bias with individuals taking ACZ more likely to have symptoms or if there may have been more of perceptual phenomenon related to a constellation of side effects. |
format |
Text |
author |
Harrison, Michael F Anderson, Paul J Johnson, Jacob B Richert, Maile Miller, Andrew D Johnson, Bruce D |
author_facet |
Harrison, Michael F Anderson, Paul J Johnson, Jacob B Richert, Maile Miller, Andrew D Johnson, Bruce D |
author_sort |
Harrison, Michael F |
title |
Acute Mountain Sickness Symptom Severity at the South Pole: The Influence of Self-Selected Prophylaxis with Acetazolamide. |
title_short |
Acute Mountain Sickness Symptom Severity at the South Pole: The Influence of Self-Selected Prophylaxis with Acetazolamide. |
title_full |
Acute Mountain Sickness Symptom Severity at the South Pole: The Influence of Self-Selected Prophylaxis with Acetazolamide. |
title_fullStr |
Acute Mountain Sickness Symptom Severity at the South Pole: The Influence of Self-Selected Prophylaxis with Acetazolamide. |
title_full_unstemmed |
Acute Mountain Sickness Symptom Severity at the South Pole: The Influence of Self-Selected Prophylaxis with Acetazolamide. |
title_sort |
acute mountain sickness symptom severity at the south pole: the influence of self-selected prophylaxis with acetazolamide. |
publisher |
Henry Ford Health Scholarly Commons |
publishDate |
2016 |
url |
https://scholarlycommons.henryford.com/emergencymedicine_articles/101 https://scholarlycommons.henryford.com/cgi/viewcontent.cgi?article=1103&context=emergencymedicine_articles |
geographic |
South Pole |
geographic_facet |
South Pole |
genre |
South pole |
genre_facet |
South pole |
op_source |
Emergency Medicine Articles |
op_relation |
https://scholarlycommons.henryford.com/emergencymedicine_articles/101 https://scholarlycommons.henryford.com/cgi/viewcontent.cgi?article=1103&context=emergencymedicine_articles |
_version_ |
1766201609302310912 |