Umbilical Cord Mercury Concentration as Biomarker of Prenatal Exposure to Methylmercury
Biomarkers are often applied to assess prenatal exposure to methylmercury in research and surveillance. In a prospective study in the Faroe Islands, the main exposure biomarkers were the mercury concentrations in cord blood and maternal hair obtained at parturition. We have now supplemented these ex...
Published in: | Environmental Health Perspectives |
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Online Access: | http://nrs.harvard.edu/urn-3:HUL.InstRepos:4553294 https://doi.org/10.1289/ehp.7842 |
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ftharvardudash:oai:dash.harvard.edu:1/4553294 2023-05-15T16:10:55+02:00 Umbilical Cord Mercury Concentration as Biomarker of Prenatal Exposure to Methylmercury Grandjean, Philippe Budtz-Jørgensen, Esben Jørgensen, Poul J. Weihe, Pál 2005 application/pdf http://nrs.harvard.edu/urn-3:HUL.InstRepos:4553294 https://doi.org/10.1289/ehp.7842 en_US eng National Institue of Environmental Health Sciences doi:10.1289/ehp.7842 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1257654/pdf/ Environmental Health Perspectives Grandjean, Philippe, Esben Budtz-Jørgensen, Poul J. Jørgensen, and Pál Weihe. 2005. Umbilical cord mercury concentration as biomarker of prenatal exposure to methylmercury. Environmental Health Perspectives 113(7): 905-908. 0091-6765 http://nrs.harvard.edu/urn-3:HUL.InstRepos:4553294 biomarker exposure assessment food contamination hair analysis mercury analysis methylmercury compounds organomercury compounds blood pregnancy prenatal exposure delayed effects preschool child seafood umbilical cord Journal Article 2005 ftharvardudash https://doi.org/10.1289/ehp.7842 2022-04-04T12:43:06Z Biomarkers are often applied to assess prenatal exposure to methylmercury in research and surveillance. In a prospective study in the Faroe Islands, the main exposure biomarkers were the mercury concentrations in cord blood and maternal hair obtained at parturition. We have now supplemented these exposure biomarkers with mercury analyses of umbilical cord tissue from 447 births. In particular, when expressed in relation to the dry weight of the tissue, the cord mercury concentration correlated very well with that in cord blood. Structural equation model analysis showed that these two biomarkers have average total imprecision of about 30%, which is much higher than the laboratory error. The imprecision of the dry-weight–based concentration was lower than that of the wet-weight–based parameter, and it was intermediate between those of the cord blood and the hair biomarkers. In agreement with this finding, regression analyses showed that the dry-weight cord mercury concentration was almost as good a predictor of methylmercury-associated neuropsychologic deficits at 7 years of age as was the cord-blood mercury concentration. Cord mercury analysis can therefore be used as a valid measure of prenatal methylmercury exposure, but appropriate adjustment for the imprecision should be considered. Version of Record Article in Journal/Newspaper Faroe Islands Harvard University: DASH - Digital Access to Scholarship at Harvard Faroe Islands Environmental Health Perspectives 113 7 905 908 |
institution |
Open Polar |
collection |
Harvard University: DASH - Digital Access to Scholarship at Harvard |
op_collection_id |
ftharvardudash |
language |
English |
topic |
biomarker exposure assessment food contamination hair analysis mercury analysis methylmercury compounds organomercury compounds blood pregnancy prenatal exposure delayed effects preschool child seafood umbilical cord |
spellingShingle |
biomarker exposure assessment food contamination hair analysis mercury analysis methylmercury compounds organomercury compounds blood pregnancy prenatal exposure delayed effects preschool child seafood umbilical cord Grandjean, Philippe Budtz-Jørgensen, Esben Jørgensen, Poul J. Weihe, Pál Umbilical Cord Mercury Concentration as Biomarker of Prenatal Exposure to Methylmercury |
topic_facet |
biomarker exposure assessment food contamination hair analysis mercury analysis methylmercury compounds organomercury compounds blood pregnancy prenatal exposure delayed effects preschool child seafood umbilical cord |
description |
Biomarkers are often applied to assess prenatal exposure to methylmercury in research and surveillance. In a prospective study in the Faroe Islands, the main exposure biomarkers were the mercury concentrations in cord blood and maternal hair obtained at parturition. We have now supplemented these exposure biomarkers with mercury analyses of umbilical cord tissue from 447 births. In particular, when expressed in relation to the dry weight of the tissue, the cord mercury concentration correlated very well with that in cord blood. Structural equation model analysis showed that these two biomarkers have average total imprecision of about 30%, which is much higher than the laboratory error. The imprecision of the dry-weight–based concentration was lower than that of the wet-weight–based parameter, and it was intermediate between those of the cord blood and the hair biomarkers. In agreement with this finding, regression analyses showed that the dry-weight cord mercury concentration was almost as good a predictor of methylmercury-associated neuropsychologic deficits at 7 years of age as was the cord-blood mercury concentration. Cord mercury analysis can therefore be used as a valid measure of prenatal methylmercury exposure, but appropriate adjustment for the imprecision should be considered. Version of Record |
format |
Article in Journal/Newspaper |
author |
Grandjean, Philippe Budtz-Jørgensen, Esben Jørgensen, Poul J. Weihe, Pál |
author_facet |
Grandjean, Philippe Budtz-Jørgensen, Esben Jørgensen, Poul J. Weihe, Pál |
author_sort |
Grandjean, Philippe |
title |
Umbilical Cord Mercury Concentration as Biomarker of Prenatal Exposure to Methylmercury |
title_short |
Umbilical Cord Mercury Concentration as Biomarker of Prenatal Exposure to Methylmercury |
title_full |
Umbilical Cord Mercury Concentration as Biomarker of Prenatal Exposure to Methylmercury |
title_fullStr |
Umbilical Cord Mercury Concentration as Biomarker of Prenatal Exposure to Methylmercury |
title_full_unstemmed |
Umbilical Cord Mercury Concentration as Biomarker of Prenatal Exposure to Methylmercury |
title_sort |
umbilical cord mercury concentration as biomarker of prenatal exposure to methylmercury |
publisher |
National Institue of Environmental Health Sciences |
publishDate |
2005 |
url |
http://nrs.harvard.edu/urn-3:HUL.InstRepos:4553294 https://doi.org/10.1289/ehp.7842 |
geographic |
Faroe Islands |
geographic_facet |
Faroe Islands |
genre |
Faroe Islands |
genre_facet |
Faroe Islands |
op_relation |
doi:10.1289/ehp.7842 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1257654/pdf/ Environmental Health Perspectives Grandjean, Philippe, Esben Budtz-Jørgensen, Poul J. Jørgensen, and Pál Weihe. 2005. Umbilical cord mercury concentration as biomarker of prenatal exposure to methylmercury. Environmental Health Perspectives 113(7): 905-908. 0091-6765 http://nrs.harvard.edu/urn-3:HUL.InstRepos:4553294 |
op_doi |
https://doi.org/10.1289/ehp.7842 |
container_title |
Environmental Health Perspectives |
container_volume |
113 |
container_issue |
7 |
container_start_page |
905 |
op_container_end_page |
908 |
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1765996046911012864 |