Concentrations of Polybrominated Diphenyl Ethers, Polychlorinated Biphenyls, and Polychlorobiphenylols in Serum from Pregnant Faroese Women and Their Children 7 Years Later
The objective of this study was to assess blood concentrations of polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs), and their polychlorobiphenylol (OH-PCB) metabolites in humans with a high seafood intake. Samples were obtained from pregnant women in the Faroe Islands in 1...
Published in: | Environmental Science & Technology |
---|---|
Main Authors: | , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
American Chemical Society (ACS)
2005
|
Subjects: | |
Online Access: | http://nrs.harvard.edu/urn-3:HUL.InstRepos:34786603 https://doi.org/10.1021/es0513032 |
id |
ftharvardudash:oai:dash.harvard.edu:1/34786603 |
---|---|
record_format |
openpolar |
spelling |
ftharvardudash:oai:dash.harvard.edu:1/34786603 2023-05-15T16:10:59+02:00 Concentrations of Polybrominated Diphenyl Ethers, Polychlorinated Biphenyls, and Polychlorobiphenylols in Serum from Pregnant Faroese Women and Their Children 7 Years Later Fängström, Britta Hovander, Lotta Bignert, Anders Athanassiadis, Ioannis Linderholm, Linda Grandjean, Philippe Weihe, Pal Bergman, Åke 2005 application/pdf http://nrs.harvard.edu/urn-3:HUL.InstRepos:34786603 https://doi.org/10.1021/es0513032 en_US eng American Chemical Society (ACS) doi:10.1021/es0513032 Environmental Science & Technology Fängström, Britta, Lotta Hovander, Anders Bignert, Ioannis Athanassiadis, Linda Linderholm, Philippe Grandjean, Pál Weihe, and Åke Bergman. 2005. “Concentrations of Polybrominated Diphenyl Ethers, Polychlorinated Biphenyls, and Polychlorobiphenylols in Serum from Pregnant Faroese Women and Their Children 7 Years Later.” Environmental Science & Technology 39 (24) (December): 9457–9463. doi:10.1021/es0513032. 0013-936X http://nrs.harvard.edu/urn-3:HUL.InstRepos:34786603 Journal Article 2005 ftharvardudash https://doi.org/10.1021/es0513032 2022-04-05T09:36:31Z The objective of this study was to assess blood concentrations of polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs), and their polychlorobiphenylol (OH-PCB) metabolites in humans with a high seafood intake. Samples were obtained from pregnant women in the Faroe Islands in 1994−1995 and from their children at 7 years of age to examine maternal transfer of the compounds to their child, age-dependent metabolism, and temporal changes. Maternal serum was dominated by 2,2‘,4,4‘-tetrabromodiphenyl ether (BDE-47), while 2,2‘,4,4‘,5,5‘-hexabromodiphenyl ether (BDE-153) prevailed in the children's serum seven years later. DecaBDE was present in both mothers and children up to 3 and 6 ng/g lipid weight, respectively. The ΣPCB concentration in the children averaged about 60% of the concentrations in their mothers, with median levels for both above 1 μg/g lipid weight and with similar PCB congener patterns. ΣOH-PCB serum concentrations from the mothers and their children showed ranges of 1.8−36 ng/g wet weight (ww) and 0.49−22 ng/g ww, respectively, with all OH-PCB congener concentrations being lower in the children, except for 2,3,3‘,4‘,5-pentachloro-4-biphenylol (4-OH-CB107). Children at 7 years of age are exposed to PCBs at levels only slightly below those of their mothers, and the increased 4-OH-CB107 concentrations in children could be due to age-related differences in PCB metabolism. The PBDE concentrations were similar in both mothers and their children. The main persistent organic pollutant concentrations in the children are most probably due to other environmental exposure than maternal transfer. Accepted Manuscript Article in Journal/Newspaper Faroe Islands Harvard University: DASH - Digital Access to Scholarship at Harvard Faroe Islands Environmental Science & Technology 39 24 9457 9463 |
institution |
Open Polar |
collection |
Harvard University: DASH - Digital Access to Scholarship at Harvard |
op_collection_id |
ftharvardudash |
language |
English |
description |
The objective of this study was to assess blood concentrations of polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs), and their polychlorobiphenylol (OH-PCB) metabolites in humans with a high seafood intake. Samples were obtained from pregnant women in the Faroe Islands in 1994−1995 and from their children at 7 years of age to examine maternal transfer of the compounds to their child, age-dependent metabolism, and temporal changes. Maternal serum was dominated by 2,2‘,4,4‘-tetrabromodiphenyl ether (BDE-47), while 2,2‘,4,4‘,5,5‘-hexabromodiphenyl ether (BDE-153) prevailed in the children's serum seven years later. DecaBDE was present in both mothers and children up to 3 and 6 ng/g lipid weight, respectively. The ΣPCB concentration in the children averaged about 60% of the concentrations in their mothers, with median levels for both above 1 μg/g lipid weight and with similar PCB congener patterns. ΣOH-PCB serum concentrations from the mothers and their children showed ranges of 1.8−36 ng/g wet weight (ww) and 0.49−22 ng/g ww, respectively, with all OH-PCB congener concentrations being lower in the children, except for 2,3,3‘,4‘,5-pentachloro-4-biphenylol (4-OH-CB107). Children at 7 years of age are exposed to PCBs at levels only slightly below those of their mothers, and the increased 4-OH-CB107 concentrations in children could be due to age-related differences in PCB metabolism. The PBDE concentrations were similar in both mothers and their children. The main persistent organic pollutant concentrations in the children are most probably due to other environmental exposure than maternal transfer. Accepted Manuscript |
format |
Article in Journal/Newspaper |
author |
Fängström, Britta Hovander, Lotta Bignert, Anders Athanassiadis, Ioannis Linderholm, Linda Grandjean, Philippe Weihe, Pal Bergman, Åke |
spellingShingle |
Fängström, Britta Hovander, Lotta Bignert, Anders Athanassiadis, Ioannis Linderholm, Linda Grandjean, Philippe Weihe, Pal Bergman, Åke Concentrations of Polybrominated Diphenyl Ethers, Polychlorinated Biphenyls, and Polychlorobiphenylols in Serum from Pregnant Faroese Women and Their Children 7 Years Later |
author_facet |
Fängström, Britta Hovander, Lotta Bignert, Anders Athanassiadis, Ioannis Linderholm, Linda Grandjean, Philippe Weihe, Pal Bergman, Åke |
author_sort |
Fängström, Britta |
title |
Concentrations of Polybrominated Diphenyl Ethers, Polychlorinated Biphenyls, and Polychlorobiphenylols in Serum from Pregnant Faroese Women and Their Children 7 Years Later |
title_short |
Concentrations of Polybrominated Diphenyl Ethers, Polychlorinated Biphenyls, and Polychlorobiphenylols in Serum from Pregnant Faroese Women and Their Children 7 Years Later |
title_full |
Concentrations of Polybrominated Diphenyl Ethers, Polychlorinated Biphenyls, and Polychlorobiphenylols in Serum from Pregnant Faroese Women and Their Children 7 Years Later |
title_fullStr |
Concentrations of Polybrominated Diphenyl Ethers, Polychlorinated Biphenyls, and Polychlorobiphenylols in Serum from Pregnant Faroese Women and Their Children 7 Years Later |
title_full_unstemmed |
Concentrations of Polybrominated Diphenyl Ethers, Polychlorinated Biphenyls, and Polychlorobiphenylols in Serum from Pregnant Faroese Women and Their Children 7 Years Later |
title_sort |
concentrations of polybrominated diphenyl ethers, polychlorinated biphenyls, and polychlorobiphenylols in serum from pregnant faroese women and their children 7 years later |
publisher |
American Chemical Society (ACS) |
publishDate |
2005 |
url |
http://nrs.harvard.edu/urn-3:HUL.InstRepos:34786603 https://doi.org/10.1021/es0513032 |
geographic |
Faroe Islands |
geographic_facet |
Faroe Islands |
genre |
Faroe Islands |
genre_facet |
Faroe Islands |
op_relation |
doi:10.1021/es0513032 Environmental Science & Technology Fängström, Britta, Lotta Hovander, Anders Bignert, Ioannis Athanassiadis, Linda Linderholm, Philippe Grandjean, Pál Weihe, and Åke Bergman. 2005. “Concentrations of Polybrominated Diphenyl Ethers, Polychlorinated Biphenyls, and Polychlorobiphenylols in Serum from Pregnant Faroese Women and Their Children 7 Years Later.” Environmental Science & Technology 39 (24) (December): 9457–9463. doi:10.1021/es0513032. 0013-936X http://nrs.harvard.edu/urn-3:HUL.InstRepos:34786603 |
op_doi |
https://doi.org/10.1021/es0513032 |
container_title |
Environmental Science & Technology |
container_volume |
39 |
container_issue |
24 |
container_start_page |
9457 |
op_container_end_page |
9463 |
_version_ |
1765996117367980032 |