Reproductive hormone profile and pubertal development in 14-year-old boys prenatally exposed to polychlorinated biphenyls
Because polychlorinated biphenyls (PCBs) are thought to cause endocrine disruption, we examined 438 adolescent boys from a birth cohort in the Faroe Islands, where PCB exposures are elevated. We measured PCBs and p,p′-dichlorodiphenyldichloroethylene (DDE) in cord blood and in serum from clinical ex...
Published in: | Reproductive Toxicology |
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ftharvardudash:oai:dash.harvard.edu:1/34767894 2023-05-15T16:10:50+02:00 Reproductive hormone profile and pubertal development in 14-year-old boys prenatally exposed to polychlorinated biphenyls Grandjean, Philippe Grønlund, Ciea Kjær, Ina M. Jensen, Tina Kold Sørensen, Nicolina Andersson, Anna-Maria Juul, Anders Skakkebæk, Niels E. Budtz-Jørgensen, Esben Weihe, Pal 2012 application/pdf http://nrs.harvard.edu/urn-3:HUL.InstRepos:34767894 https://doi.org/10.1016/j.reprotox.2012.07.005 en_US eng Elsevier BV doi:10.1016/j.reprotox.2012.07.005 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3513575/ Reproductive Toxicology Grandjean, Philippe, Ciea Grønlund, Ina M. Kjær, Tina Kold Jensen, Nicolina Sørensen, Anna-Maria Andersson, Anders Juul, Niels E. Skakkebæk, Esben Budtz-Jørgensen, and Pal Weihe. 2012. “Reproductive Hormone Profile and Pubertal Development in 14-Year-Old Boys Prenatally Exposed to Polychlorinated Biphenyls.” Reproductive Toxicology 34 (4) (December): 498–503. doi:10.1016/j.reprotox.2012.07.005. 0890-6238 http://nrs.harvard.edu/urn-3:HUL.InstRepos:34767894 Adolescent development Delayed puberty Polychlorinated biphenyls Prenatal exposure delayed effects Reproductive hormones Journal Article 2012 ftharvardudash https://doi.org/10.1016/j.reprotox.2012.07.005 2022-04-05T18:51:25Z Because polychlorinated biphenyls (PCBs) are thought to cause endocrine disruption, we examined 438 adolescent boys from a birth cohort in the Faroe Islands, where PCB exposures are elevated. We measured PCBs and p,p′-dichlorodiphenyldichloroethylene (DDE) in cord blood and in serum from clinical examination at age 14. Higher prenatal PCB exposure was associated with lower serum concentrations of both luteinizing hormone (LH) and testosterone. In addition, sex hormone binding globulin (SHBG) was positively associated with both prenatal and concurrent PCB exposures. The PCB-SHBG association was robust to covariate adjustment. In a structural equation model, a doubling in prenatal PCB exposure was associated with a decrease in LH of 6% (p = 0.03). Prenatal exposure to PCB and DDE showed weak, non-significant inverse associations with testicular size and Tanner stage. DDE was highly correlated with PCB and showed slightly weaker associations with the hormone profile. These findings suggest that delayed puberty with low serum-LH concentrations associated with developmental exposure to non dioxin-like PCBs may be due to a central hypothalamo-pituitary mechanism. Accepted Manuscript Article in Journal/Newspaper Faroe Islands Harvard University: DASH - Digital Access to Scholarship at Harvard Faroe Islands Reproductive Toxicology 34 4 498 503 |
institution |
Open Polar |
collection |
Harvard University: DASH - Digital Access to Scholarship at Harvard |
op_collection_id |
ftharvardudash |
language |
English |
topic |
Adolescent development Delayed puberty Polychlorinated biphenyls Prenatal exposure delayed effects Reproductive hormones |
spellingShingle |
Adolescent development Delayed puberty Polychlorinated biphenyls Prenatal exposure delayed effects Reproductive hormones Grandjean, Philippe Grønlund, Ciea Kjær, Ina M. Jensen, Tina Kold Sørensen, Nicolina Andersson, Anna-Maria Juul, Anders Skakkebæk, Niels E. Budtz-Jørgensen, Esben Weihe, Pal Reproductive hormone profile and pubertal development in 14-year-old boys prenatally exposed to polychlorinated biphenyls |
topic_facet |
Adolescent development Delayed puberty Polychlorinated biphenyls Prenatal exposure delayed effects Reproductive hormones |
description |
Because polychlorinated biphenyls (PCBs) are thought to cause endocrine disruption, we examined 438 adolescent boys from a birth cohort in the Faroe Islands, where PCB exposures are elevated. We measured PCBs and p,p′-dichlorodiphenyldichloroethylene (DDE) in cord blood and in serum from clinical examination at age 14. Higher prenatal PCB exposure was associated with lower serum concentrations of both luteinizing hormone (LH) and testosterone. In addition, sex hormone binding globulin (SHBG) was positively associated with both prenatal and concurrent PCB exposures. The PCB-SHBG association was robust to covariate adjustment. In a structural equation model, a doubling in prenatal PCB exposure was associated with a decrease in LH of 6% (p = 0.03). Prenatal exposure to PCB and DDE showed weak, non-significant inverse associations with testicular size and Tanner stage. DDE was highly correlated with PCB and showed slightly weaker associations with the hormone profile. These findings suggest that delayed puberty with low serum-LH concentrations associated with developmental exposure to non dioxin-like PCBs may be due to a central hypothalamo-pituitary mechanism. Accepted Manuscript |
format |
Article in Journal/Newspaper |
author |
Grandjean, Philippe Grønlund, Ciea Kjær, Ina M. Jensen, Tina Kold Sørensen, Nicolina Andersson, Anna-Maria Juul, Anders Skakkebæk, Niels E. Budtz-Jørgensen, Esben Weihe, Pal |
author_facet |
Grandjean, Philippe Grønlund, Ciea Kjær, Ina M. Jensen, Tina Kold Sørensen, Nicolina Andersson, Anna-Maria Juul, Anders Skakkebæk, Niels E. Budtz-Jørgensen, Esben Weihe, Pal |
author_sort |
Grandjean, Philippe |
title |
Reproductive hormone profile and pubertal development in 14-year-old boys prenatally exposed to polychlorinated biphenyls |
title_short |
Reproductive hormone profile and pubertal development in 14-year-old boys prenatally exposed to polychlorinated biphenyls |
title_full |
Reproductive hormone profile and pubertal development in 14-year-old boys prenatally exposed to polychlorinated biphenyls |
title_fullStr |
Reproductive hormone profile and pubertal development in 14-year-old boys prenatally exposed to polychlorinated biphenyls |
title_full_unstemmed |
Reproductive hormone profile and pubertal development in 14-year-old boys prenatally exposed to polychlorinated biphenyls |
title_sort |
reproductive hormone profile and pubertal development in 14-year-old boys prenatally exposed to polychlorinated biphenyls |
publisher |
Elsevier BV |
publishDate |
2012 |
url |
http://nrs.harvard.edu/urn-3:HUL.InstRepos:34767894 https://doi.org/10.1016/j.reprotox.2012.07.005 |
geographic |
Faroe Islands |
geographic_facet |
Faroe Islands |
genre |
Faroe Islands |
genre_facet |
Faroe Islands |
op_relation |
doi:10.1016/j.reprotox.2012.07.005 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3513575/ Reproductive Toxicology Grandjean, Philippe, Ciea Grønlund, Ina M. Kjær, Tina Kold Jensen, Nicolina Sørensen, Anna-Maria Andersson, Anders Juul, Niels E. Skakkebæk, Esben Budtz-Jørgensen, and Pal Weihe. 2012. “Reproductive Hormone Profile and Pubertal Development in 14-Year-Old Boys Prenatally Exposed to Polychlorinated Biphenyls.” Reproductive Toxicology 34 (4) (December): 498–503. doi:10.1016/j.reprotox.2012.07.005. 0890-6238 http://nrs.harvard.edu/urn-3:HUL.InstRepos:34767894 |
op_doi |
https://doi.org/10.1016/j.reprotox.2012.07.005 |
container_title |
Reproductive Toxicology |
container_volume |
34 |
container_issue |
4 |
container_start_page |
498 |
op_container_end_page |
503 |
_version_ |
1765995981862600704 |