Prediagnostic plasma concentrations of organochlorines and risk of B-cell non-Hodgkin lymphoma in envirogenomarkers: a nested case-control study
Background: Evidence suggests a largely environmental component to non-Hodgkin’s lymphoma (NHL). Persistent organic pollutants (POPs) including polychlorinated biphenyls (PCBs), DDE and HCB have been repeatedly implicated, but the literature is inconsistent and a causal relationship remains to be de...
Published in: | Environmental Health |
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Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
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BioMed Central
2017
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Online Access: | http://nrs.harvard.edu/urn-3:HUL.InstRepos:31731887 https://doi.org/10.1186/s12940-017-0214-8 |
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ftharvardudash:oai:dash.harvard.edu:1/31731887 |
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Open Polar |
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Harvard University: DASH - Digital Access to Scholarship at Harvard |
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ftharvardudash |
language |
English |
topic |
Non Hodgkin lymphoma Polychlorinated biphenyls DDE HCB Organochlorines EnviroGenoMarkers |
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Non Hodgkin lymphoma Polychlorinated biphenyls DDE HCB Organochlorines EnviroGenoMarkers Kelly, Rachel S. Kiviranta, Hannu Bergdahl, Ingvar A. Palli, Domenico Johansson, Ann-Sofie Botsivali, Maria Vineis, Paolo Vermeulen, Roel Kyrtopoulos, Soterios A. Chadeau-Hyam, Marc Keun, Hector C. Athersuch, Toby J. vanVeldhoven, Karin Jonsson, Bo Melin, Beatrice Lenner, Per Georgiadis, Panagiotis Papadopoulou, Christina Chatziioannou, Aristotelis Valavanis, Ioannis Sacerdote, Carlotta Portengen, Lützen Saberi-Hosnijeh, Fatemeh Hebels, Dennie G. A. J. Kleinjans, Jos C. S. de Kok, Theo M. C. M. Gottschalk, Ralph van Leeuwen, Danitsja Timmermans, Leen Hallmans, Göran Bendinelli, Benedetta Krogh, Vittorio Tumino, Rosario Panico, Salvatore Kogevinas, Manolis Stephanou, Euripides G. Myridakis, Antonis Fazzo, Lucia De Santis, Marco Comba, Pietro Rantakokko, Panu Airaksinen, Riikka Ruokojärvi, Päivi Gilthorpe, Mark Fleming, Sarah Fleming, Thomas Tu, Yu-Kang Chen, Wei J. Lee, Wen-Chung Hsiao, Chuhsing Kate Chien, Kuo-Liong Kuo, Po-Hsiu Hung, Hung Liao, Shu-Fen Lundh, Thoma Prediagnostic plasma concentrations of organochlorines and risk of B-cell non-Hodgkin lymphoma in envirogenomarkers: a nested case-control study |
topic_facet |
Non Hodgkin lymphoma Polychlorinated biphenyls DDE HCB Organochlorines EnviroGenoMarkers |
description |
Background: Evidence suggests a largely environmental component to non-Hodgkin’s lymphoma (NHL). Persistent organic pollutants (POPs) including polychlorinated biphenyls (PCBs), DDE and HCB have been repeatedly implicated, but the literature is inconsistent and a causal relationship remains to be determined. Methods: The EnviroGenoMarkers study is nested within two prospective cohorts EPIC-Italy and the Northern Sweden Health and Disease Study. Six PCB congeners, DDE and HCB were measured in blood plasma samples provided at recruitment using gas-chromatography mass spectrometry. During 16 years follow-up 270 incident cases of B-cell NHL (including 76 cases of multiple myeloma) were diagnosed. Cases were matched to 270 healthy controls by centre, age, gender and date of blood collection. Cases were categorised into ordered quartiles of exposure for each POP based on the distribution of exposure in the control population. Logistic regression was applied to assess the association with risk, multivariate and stratified analyses were performed to identify confounders or effect modifiers. Results: The exposures displayed a strong degree of correlation, particularly amongst those PCBs with similar degrees of chlorination. There was no significant difference (p < 0.05) in median exposure levels between cases and controls for any of the investigated exposures. However under a multivariate model PCB138, PCB153, HCB and DDE displayed significant inverse trends (Wald test p-value <0.05). Under stratified analyses these were determined to be driven by males and by the Diffuse Large B-Cell Lymphoma subtype. When considering those in the highest levels of exposure (>90th percentile) the association was null for all POPs Conclusion: We report no evidence that a higher body burden of PCBs, DDE or HCB increased the risk of subsequent NHL diagnosis. Significantly inverse associations were noted for males with a number of the investigated POPs. We hypothesize these unexpected relationships may relate to the subtype composition of our population, effect modification by BMI or other unmeasured confounding. This study provides no additional support for the previously observed role of PCBs, DDE and HCB as risk factors for NHL. Electronic supplementary material The online version of this article (doi:10.1186/s12940-017-0214-8) contains supplementary material, which is available to authorized users. Version of Record |
format |
Article in Journal/Newspaper |
author |
Kelly, Rachel S. Kiviranta, Hannu Bergdahl, Ingvar A. Palli, Domenico Johansson, Ann-Sofie Botsivali, Maria Vineis, Paolo Vermeulen, Roel Kyrtopoulos, Soterios A. Chadeau-Hyam, Marc Keun, Hector C. Athersuch, Toby J. vanVeldhoven, Karin Jonsson, Bo Melin, Beatrice Lenner, Per Georgiadis, Panagiotis Papadopoulou, Christina Chatziioannou, Aristotelis Valavanis, Ioannis Sacerdote, Carlotta Portengen, Lützen Saberi-Hosnijeh, Fatemeh Hebels, Dennie G. A. J. Kleinjans, Jos C. S. de Kok, Theo M. C. M. Gottschalk, Ralph van Leeuwen, Danitsja Timmermans, Leen Hallmans, Göran Bendinelli, Benedetta Krogh, Vittorio Tumino, Rosario Panico, Salvatore Kogevinas, Manolis Stephanou, Euripides G. Myridakis, Antonis Fazzo, Lucia De Santis, Marco Comba, Pietro Rantakokko, Panu Airaksinen, Riikka Ruokojärvi, Päivi Gilthorpe, Mark Fleming, Sarah Fleming, Thomas Tu, Yu-Kang Chen, Wei J. Lee, Wen-Chung Hsiao, Chuhsing Kate Chien, Kuo-Liong Kuo, Po-Hsiu Hung, Hung Liao, Shu-Fen Lundh, Thoma |
author_facet |
Kelly, Rachel S. Kiviranta, Hannu Bergdahl, Ingvar A. Palli, Domenico Johansson, Ann-Sofie Botsivali, Maria Vineis, Paolo Vermeulen, Roel Kyrtopoulos, Soterios A. Chadeau-Hyam, Marc Keun, Hector C. Athersuch, Toby J. vanVeldhoven, Karin Jonsson, Bo Melin, Beatrice Lenner, Per Georgiadis, Panagiotis Papadopoulou, Christina Chatziioannou, Aristotelis Valavanis, Ioannis Sacerdote, Carlotta Portengen, Lützen Saberi-Hosnijeh, Fatemeh Hebels, Dennie G. A. J. Kleinjans, Jos C. S. de Kok, Theo M. C. M. Gottschalk, Ralph van Leeuwen, Danitsja Timmermans, Leen Hallmans, Göran Bendinelli, Benedetta Krogh, Vittorio Tumino, Rosario Panico, Salvatore Kogevinas, Manolis Stephanou, Euripides G. Myridakis, Antonis Fazzo, Lucia De Santis, Marco Comba, Pietro Rantakokko, Panu Airaksinen, Riikka Ruokojärvi, Päivi Gilthorpe, Mark Fleming, Sarah Fleming, Thomas Tu, Yu-Kang Chen, Wei J. Lee, Wen-Chung Hsiao, Chuhsing Kate Chien, Kuo-Liong Kuo, Po-Hsiu Hung, Hung Liao, Shu-Fen Lundh, Thoma |
author_sort |
Kelly, Rachel S. |
title |
Prediagnostic plasma concentrations of organochlorines and risk of B-cell non-Hodgkin lymphoma in envirogenomarkers: a nested case-control study |
title_short |
Prediagnostic plasma concentrations of organochlorines and risk of B-cell non-Hodgkin lymphoma in envirogenomarkers: a nested case-control study |
title_full |
Prediagnostic plasma concentrations of organochlorines and risk of B-cell non-Hodgkin lymphoma in envirogenomarkers: a nested case-control study |
title_fullStr |
Prediagnostic plasma concentrations of organochlorines and risk of B-cell non-Hodgkin lymphoma in envirogenomarkers: a nested case-control study |
title_full_unstemmed |
Prediagnostic plasma concentrations of organochlorines and risk of B-cell non-Hodgkin lymphoma in envirogenomarkers: a nested case-control study |
title_sort |
prediagnostic plasma concentrations of organochlorines and risk of b-cell non-hodgkin lymphoma in envirogenomarkers: a nested case-control study |
publisher |
BioMed Central |
publishDate |
2017 |
url |
http://nrs.harvard.edu/urn-3:HUL.InstRepos:31731887 https://doi.org/10.1186/s12940-017-0214-8 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_relation |
doi:10.1186/s12940-017-0214-8 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312563/pdf/ Environmental Health Kelly, R. S., H. Kiviranta, I. A. Bergdahl, D. Palli, A. Johansson, M. Botsivali, P. Vineis, et al. 2017. “Prediagnostic plasma concentrations of organochlorines and risk of B-cell non-Hodgkin lymphoma in envirogenomarkers: a nested case-control study.” Environmental Health 16 (1): 9. doi:10.1186/s12940-017-0214-8. http://dx.doi.org/10.1186/s12940-017-0214-8. http://nrs.harvard.edu/urn-3:HUL.InstRepos:31731887 |
op_doi |
https://doi.org/10.1186/s12940-017-0214-8 |
container_title |
Environmental Health |
container_volume |
16 |
container_issue |
1 |
_version_ |
1766148063401869312 |
spelling |
ftharvardudash:oai:dash.harvard.edu:1/31731887 2023-05-15T17:45:13+02:00 Prediagnostic plasma concentrations of organochlorines and risk of B-cell non-Hodgkin lymphoma in envirogenomarkers: a nested case-control study Kelly, Rachel S. Kiviranta, Hannu Bergdahl, Ingvar A. Palli, Domenico Johansson, Ann-Sofie Botsivali, Maria Vineis, Paolo Vermeulen, Roel Kyrtopoulos, Soterios A. Chadeau-Hyam, Marc Keun, Hector C. Athersuch, Toby J. vanVeldhoven, Karin Jonsson, Bo Melin, Beatrice Lenner, Per Georgiadis, Panagiotis Papadopoulou, Christina Chatziioannou, Aristotelis Valavanis, Ioannis Sacerdote, Carlotta Portengen, Lützen Saberi-Hosnijeh, Fatemeh Hebels, Dennie G. A. J. Kleinjans, Jos C. S. de Kok, Theo M. C. M. Gottschalk, Ralph van Leeuwen, Danitsja Timmermans, Leen Hallmans, Göran Bendinelli, Benedetta Krogh, Vittorio Tumino, Rosario Panico, Salvatore Kogevinas, Manolis Stephanou, Euripides G. Myridakis, Antonis Fazzo, Lucia De Santis, Marco Comba, Pietro Rantakokko, Panu Airaksinen, Riikka Ruokojärvi, Päivi Gilthorpe, Mark Fleming, Sarah Fleming, Thomas Tu, Yu-Kang Chen, Wei J. Lee, Wen-Chung Hsiao, Chuhsing Kate Chien, Kuo-Liong Kuo, Po-Hsiu Hung, Hung Liao, Shu-Fen Lundh, Thoma 2017 application/pdf http://nrs.harvard.edu/urn-3:HUL.InstRepos:31731887 https://doi.org/10.1186/s12940-017-0214-8 en_US eng BioMed Central doi:10.1186/s12940-017-0214-8 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312563/pdf/ Environmental Health Kelly, R. S., H. Kiviranta, I. A. Bergdahl, D. Palli, A. Johansson, M. Botsivali, P. Vineis, et al. 2017. “Prediagnostic plasma concentrations of organochlorines and risk of B-cell non-Hodgkin lymphoma in envirogenomarkers: a nested case-control study.” Environmental Health 16 (1): 9. doi:10.1186/s12940-017-0214-8. http://dx.doi.org/10.1186/s12940-017-0214-8. http://nrs.harvard.edu/urn-3:HUL.InstRepos:31731887 Non Hodgkin lymphoma Polychlorinated biphenyls DDE HCB Organochlorines EnviroGenoMarkers Journal Article 2017 ftharvardudash https://doi.org/10.1186/s12940-017-0214-8 2022-04-05T09:36:11Z Background: Evidence suggests a largely environmental component to non-Hodgkin’s lymphoma (NHL). Persistent organic pollutants (POPs) including polychlorinated biphenyls (PCBs), DDE and HCB have been repeatedly implicated, but the literature is inconsistent and a causal relationship remains to be determined. Methods: The EnviroGenoMarkers study is nested within two prospective cohorts EPIC-Italy and the Northern Sweden Health and Disease Study. Six PCB congeners, DDE and HCB were measured in blood plasma samples provided at recruitment using gas-chromatography mass spectrometry. During 16 years follow-up 270 incident cases of B-cell NHL (including 76 cases of multiple myeloma) were diagnosed. Cases were matched to 270 healthy controls by centre, age, gender and date of blood collection. Cases were categorised into ordered quartiles of exposure for each POP based on the distribution of exposure in the control population. Logistic regression was applied to assess the association with risk, multivariate and stratified analyses were performed to identify confounders or effect modifiers. Results: The exposures displayed a strong degree of correlation, particularly amongst those PCBs with similar degrees of chlorination. There was no significant difference (p < 0.05) in median exposure levels between cases and controls for any of the investigated exposures. However under a multivariate model PCB138, PCB153, HCB and DDE displayed significant inverse trends (Wald test p-value <0.05). Under stratified analyses these were determined to be driven by males and by the Diffuse Large B-Cell Lymphoma subtype. When considering those in the highest levels of exposure (>90th percentile) the association was null for all POPs Conclusion: We report no evidence that a higher body burden of PCBs, DDE or HCB increased the risk of subsequent NHL diagnosis. Significantly inverse associations were noted for males with a number of the investigated POPs. We hypothesize these unexpected relationships may relate to the subtype composition of our population, effect modification by BMI or other unmeasured confounding. This study provides no additional support for the previously observed role of PCBs, DDE and HCB as risk factors for NHL. Electronic supplementary material The online version of this article (doi:10.1186/s12940-017-0214-8) contains supplementary material, which is available to authorized users. Version of Record Article in Journal/Newspaper Northern Sweden Harvard University: DASH - Digital Access to Scholarship at Harvard Environmental Health 16 1 |